ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

QLPA
[cc/s]
Fig. 4 – Left: Flow curves at the LPA from MR (black), in case of equal Zr and Zl (blue) and in case of Zr
being twice Zl (red); right: flow velocity pathlines in a stenotic patient at peak systole.
5. DISCUSSION
Combining MR image data with patient-specific computational modelling helped to
better understand the fluid dynamics conditions in patients affected by stenosis of the
pulmonary artery branches. Particularly, from the comparison between the Control
group and the Stenotic group it emerged that the presence of a stenotic branch causes a
vascular remodelling, thus a mismatch in the right and left PVRs. The developed
methodology applied to patients with known flow data and pressures will allow
understanding whether it is the lung belonging to the stenotic side to decrease the
vascular resistances, or the contralateral lung to increase them. Furthermore, it will help
clinicians in deciding whether a stent implantation in the stenosis is preferable.
6. ACKNOWLEDGEMENTS
This research is funded by the European Union 7 th Framework Programme (FP7/2007-
2013) under grant agreement n° 238113 (project MeDDiCA).
8. REFERENCES
time [s]
v
[m/s]
1. Cohen, M. D., Johnson T. and Ramrakhiani S., MRI Surgical Repair of
Transposition of the Great Vessels, A. J. R., 2010, Vol. 194, 250-60.
2. Ntsinjana, H. N., Hughes M. L. and Taylor A. M., The Role of Cardiovascular
Magnetic Resonance in Pediatric Congenital Heart Disease, Vol. 21, 13-51.
3. Cohn L. H., Sanders J.H. and Collins J. J., Surgical treatment of congenital
unilateral pulmonary arterial stenosis with contralateral pulmonary hypertension,
Am. J. Cardiol., 1976, Vol. 38, 257-60.
4. Spilker R. L. and Taylor C. A., Tuning Multidomain Hemodynamic Simulations to
Match Physiological Measurements, Ann Biomed Eng, 2010, Vol. 38, 2635-48.
5. Muthurangu V., Taylor A. M., Andriantsimiavona R., Hegde S., Miquel M. E.,
Tulloh R., Baker E., Hill D. L. and Razavi R. S., Novel method of quantifying
pulmonary vascular resistance by use of simultaneous invasive pressure monitoring
and phase-constract magnetic resonance flow, 2004, Vol. 100, Issue 7, 826-34.
2.1
0.0