ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

PATIENT-SPECIFIC EVALUATION OF PULMONARY VASCULAR
RESISTANCES AFTER CORRECTED TRANSPOSITION OF THE
GREAT ARTERIES
D. Cosentino 1 , G. Tanda 2 , A. Bavo 3 , M. Quail 4 , H. Ntsinjana 5 , V. Diaz-Zuccarini 6 ,
F. Migliavacca 7 , G. Pennati 8 , A.M. Taylor 9 and S. Schievano 10
1. ABSTRACT
Patients with corrected transposition of the great arteries (TGA) can develop unilateral
pulmonary stenosis as a long-term complication of the surgical correction. It is assumed
that pulmonary vascular resistances (PVR) in these patients remodel to allow the lung in
the stenotic side to be correctly perfused. A patient-specific computational model was
developed using MR and flow patients’ data to better understand this phenomenon and
to evaluate the fluid dynamics in this class of patients.
2. INTRODUCTION
Transposition of the great arteries is a congenital heart defect with the aorta arising from
the right ventricle, and the main pulmonary artery (MPA) arising from the left ventricle
[Cohen et al., 2010]. Such defect has to be corrected within the first 2 weeks of life, and
the method currently used for the correction is the arterial switch operation (ASO). One
of the major long-term complications of ASO is branch pulmonary artery (PA) stenosis
1 PhD Student, Department of Mechanical Engineering, University College London, UCL- Torrington
Place, WC1E 7JE, London, UK
2 MSc Student, Laboratory of Biological Structures, Politecnico di Milano, LaBS- Piazza Leonardo Da
Vinci 32, 20133, Milano, Italy
3 MSc Student, Laboratory of Biological Structures, Politecnico di Milano, LaBS- Piazza Leonardo Da
Vinci 32, 20133, Milano, Italy
4 Clinical Fellow, Great Ormond Street Hospital for Children & Institute of Cardiovascular Science,
University College London, Great Ormond Street, WC1N 3JH, London, UK
5 Clinical Fellow, Great Ormond Street Hospital for Children & Institute of Cardiovascular Science,
University College London, Great Ormond Street, WC1N 3JH, London, UK
6 Lecturer, Department of Mechanical Engineering, University College London, UCL- Torrington Place,
WC1E 7JE, London, UK
7 Professor, Laboratory of Biological Structures, Politecnico di Milano, LaBS- Piazza Leonardo Da Vinci
32, 20133, Milano, Italy
8 Professor, Laboratory of Biological Structures, Politecnico di Milano, LaBS- Piazza Leonardo Da Vinci
32, 20133, Milano, Italy
9 Professor, Great Ormond Street Hospital for Children & Institute of Cardiovascular Science, University
College of London, Great Ormond Street, WC1N 3JH, London, UK
10 Research Fellow, Great Ormond Street Hospital for Children & Institute of Cardiovascular Science,
University College of London, Great Ormond Street, WC1N 3JH, London, UK