ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

model versatility. The disagreement found among results may be explained by the invitro
presence of pipe connections, in particular the manifold collecting the
brachiocephalic outlets that, even though not intended to be part of the multiscale
model, is likely to produce remarkable energy dissipation.
5. CONCLUSION
This work combines, for the first time, computational and experimental modeling to
study the hemodynamics in a patient-specific Norwood anatomy with mBT shunt and
AC, using a multiscale approach. Validation of the computational model against
experimental data is important when investigating complex hemodynamics but, on the
other hand, in-silico simulations can improve the understanding of in-vitro experiments.
6. REFERENCES
1) Norwood, W. I., Hypoplastic left heart syndrome, Ann. Thorac. Surg., 1991, Vol.
52, 688-95.
2) Yuan, S. M., Shinfeld A. and Raanani E., The Blalock-Taussig shunt, J. Card. Surg.,
2009, Vol. 24, 101-8.
3) Pennati, G., Migliavacca F., Dubini G. and Bove E. L., Modeling of systemic-topulmonary
shunts in newborns with a univentricular circulation: State of the art and
future directions, Prog. Pediatr. Cardiol., 2010, Vol. 30, 23–9.
4) Biglino, G., Giardini A., Baker C., Hsia T. Y., Figliola R. S., Taylor A. M. and
Schievano S., In vitro study of the Norwood palliation: a patient-specific mock
circulatory system, ASAIO J., 2012, Vol. 58, 25-31.
5) Qian, Y., Liu L., Itatani K., Miyaji K. and Umezu M., Computational Hemodynamic
Analysis in Congenital Heart Disease: Simulation of the Norwood Procedure, Ann.
Biomed. Eng., 2010, Vol. 38, 2302–13.
6) Ladisa, J. F. Jr, Taylor C. A. and Feinstein J. A., Aortic Coarctation: Recent
Developments in Experimental and Computational Methods to Assess Treatments
for this simple Condition, Prog. Pediatr. Cardiol., 2010, Vol. 30, 45-49.
7) Olivieri, L. J., de Zélicourt D. A., Haggerty C. M., Ratnayaka K., Cross R. R. and
Yoganathan A. P., Hemodynamic Modeling of Surgically Repaired Coarctation of
the Aorta, Cardiovasc. Eng. Technol., 2011, Vol. 2, 288-95.
8) Migliavacca, F., Balossino R., Pennati G., Dubini G., Hsia T. Y., de Leval M. R.
and Bove E. L., Multiscale modeling in biofluidynamics: application to
reconstructive paediatric cardiac surgery, J. Biomech., 2006, Vol. 39, 1010-20.
9) Apel, J., Neudel F. and Reul H., Computational fluid dynamics and experimental
validation of a microaxial blood pump, ASAIO J., 2001, Vol. 47, 552-8.
10) Keshavarz-Motamed, Z., Garcia J., Pibarot P., Larose E. and Kadem L., Modeling
the impact of concomitant aortic stenosis and coarctation of the aorta on left
ventricular workload, J. Biomech., 2011, Vol. 44, 2817-25.
11) Migliavacca, F., Pennati G., Dubini G., Fumero R., Pietrabissa R., Urcelay G., Bove
E. L., Hsia T. Y. and de Leval M. R., Modeling of the Norwood circulation: effects
of shunt size, vascular resistances, and heart rate, Am. J. Physiol. Heart Circ.
Physiol., 2001, Vol. 280, H2076-86.
12) Reul, H., Tesch B., Schoenmackers J. and Effert S., Hydromechanical simulation of
systemic circulation, Med. Biol. Eng., 1974, Vol. 12, 431-6.