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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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al., (2008) and thereby adopting the growth laws from those articles. The main objective<br />

of the present work is to simulate how the localized metal implant generates a healthy<br />

mechanical environment for the articular cartilage in the knee joint. In this work we<br />

have modeled the cartilage growth for only one day and models will be improved to<br />

simulate the growth for longer time period by incorporating more realistic in vivo<br />

conditions and stimulated growth by triggering criteria. Results will demonstrate how<br />

the implant’s position in the lining tissue and biomechanical factors affect the growth<br />

and behavior of cartilage surrounding the cartilage. A contribution of this work is to<br />

illustrate how tissue growth models can be used to simulate the effect of biomechanical<br />

factors on the implant performance to treat the focal articular cartilage defects, so that<br />

implant design and precise surgical procedure can be improvised.<br />

6. REFERENCES<br />

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grading system vs the new OARSI osteoarthritis cartilagehistopathology assessment<br />

system. Osteoarthritis and Cartilage 15(11):1241–1248 (2007)<br />

2. Manda K, Ryd L, Eriksson A, Finite element simulations of a focal knee resurfacing<br />

implant applied to localized cartilage defects in a sheep model. Journal of<br />

Biomechanics 44(5):794–801 (2011)<br />

3. Manda K, Eriksson A, Time-dependent behavior of cartilage surrounding a metal<br />

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(2011)<br />

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5. Klisch, S. M., Asanbaeva, A., Oungoulian, S. R., Thonar, E. J., Masuda, K., Davol,<br />

A., and Sah, R. L., 2008, “A Cartilage Growth Mixture Model With Collagen<br />

Remodeling: Validation Protocols,” ASME J. Biomech. Eng., 130, p.031006.<br />

6. Darling EM, Athanasiou KA, Biomechanical strategies for articular cartilage<br />

regeneration, Annals of Biomedical Engineering, 31, 1114-1124 (2003)<br />

7. Baaijens F, Bouten C, Driessen N, Modeling collagen remodeling, Journal of<br />

Biomechanics 43 (2010) 166–175<br />

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cartilage, ASME J. of Biomech. Eng., 129, pp. 250-258 (2009)<br />

9. Davol A, Bingham MS, Sah RL, Klisch SM, A nonlinear finite element model of<br />

cartilage growth. Biomechanics and Modeling in Mechanobiology 7(4):295–307<br />

(2008)<br />

10. Ficklin TP, Davol A, Klisch SM Simulating the growth of articular cartilage<br />

explants in a permeation bioreactor to aid in experimental protocol design, Journal<br />

of Biomechanical Engineering 131(4): 041008:1-10 (2009)<br />

11. Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJMA, Davol A, Sah<br />

Rl, A cartilage growth mixture model with collagen remodeling: validation<br />

protocols, Journal of Biomechanical Engineering, 130, 031006:1-11 (2008)<br />

12. Wilson W, van Rietbergen B, van Donkelaar CC, Huiskes R., Pathways of loadinduced<br />

cartilage damage causing cartilage degeneration in the knee after<br />

meniscectomy. Journal of Biomechanics 36(6), 845–851 (2003)

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