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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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initialization. Using built-in and custom-written function facilities provided by the<br />

software, the quantities given in Table 1 were calculated:<br />

1. Variation of Instantaneous Maximum<br />

Velocity within the aneurysm sac<br />

2. Maximum of Instantaneous Maximum<br />

Velocity by time within the aneurysm sac<br />

3. Average of Instantaneous Maximum<br />

Velocity by time within the aneurysm sac<br />

4. Variation of Instantaneous Average<br />

Velocity within the aneurysm sac<br />

5. Maximum of Instantaneous Maximum<br />

Velocity by time within the aneurysm<br />

6. Average of Instantaneous Maximum<br />

Velocity by time within the aneurysm<br />

u~<br />

max<br />

t<br />

t , 2 <br />

u<br />

, <br />

t , max u x <br />

uˆ max max x t 2<br />

1 T<br />

umax<br />

tdt<br />

T max u x,<br />

,<br />

0<br />

2 t<br />

<br />

t dV<br />

u~ u x,<br />

2<br />

aver t <br />

dV<br />

ˆ max u~<br />

t<br />

<br />

ux,<br />

t<br />

2<br />

dV<br />

uaver aver<br />

u<br />

1<br />

<br />

T<br />

T<br />

aver 0<br />

dV<br />

dt<br />

Table 1 – Proposed Comparative Measures for Stent Efficiency<br />

Vanev dV<br />

The aneurysm volume is defined as<br />

and T is one cardiac cycle period (1<br />

sec), u is the velocity vector, x is the spatial coordinates in 3D and<br />

..<br />

2 is L2 norm.<br />

3. RESULTS AND DISCUSSION<br />

The results of other average data are developed following formulation in Table 1 and<br />

percent of those parameters against deployment, as well as aneurysm volumes (i.e.,<br />

1-stented/unstented) are given in Table 2. Also, a sample view of how flow field<br />

changes for patient 4 is given in Figure 3.<br />

u max û max u aver û aver V anev Medical Outcome<br />

Minimal region of flow<br />

remaining after 1 year.<br />

Immediate clotting of<br />

Patient 1 6.3% 0.4% 41.1% 49.9% 222.03<br />

Patient 2 -6.7% -11.1% 43.6% 41.9% 3859.45<br />

Patient 3 7.9% 3.6% 45.5% 38.8% 93.44<br />

whole anurysm<br />

Complete clotting after 6<br />

months<br />

Patient 4 15.0% 10.2% 70.3% 68.0% 3951.85 Hemorrage – 1 week later<br />

Table 2 - Change of Stent Efficiency Measures<br />

An outcome is that, stent deployment has increased the oscillation over mean for all<br />

quantities, except for patient 1. It is also seen that, the greater the aneurysm, the greater<br />

the peak velocity compared to global motion in the aneurysm; a parameter which is<br />

greatly influenced by the application of a stent.<br />

Clotting of blood is dependent to flow, as well as chemical parameters [8]. Poor<br />

aneurysm treatment is fatal, and this risk is always present. Thus, it has been presumed<br />

and seen in previous studies (as in [8,9]) that the clotting within aneurysm should be a<br />

function of flow parameters within the aneurysm sac [9]. Though this study is limited to

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