ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

intracellular dynamics, rather than some phenomenological “rules” as was the case in
the hybrid model of Peiffer et al. [9]. This allows gaining more insight into the
fundamental processes at the micro-scale that in turn give rise to the emergent behavior
seen at the macro-scale. In conclusion, the proposed multiscale model was found to be a
useful tool to investigate possible biological mechanisms across different time and
spatial scales, thereby contributing to the fundamental knowledge of sprouting
angiogenesis in both normal and pathological conditions.
6. ACKNOWLEDGEMENTS
Aurélie Carlier is a PhD fellow of the Research Foundation Flanders (FWO
Vlaanderen). The work is part of Prometheus, the Leuven Research and Development
Division of Skeletal Tissue Engineering of the Katholieke Universiteit Leuven:
www.kuleuven.be/Prometheus. This work was supported by the Special Research Fund
of the University of Liège (FRS.D-10/20).
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