ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

atio experimented by both wounds is very similar.
Fig. 1 Initial (day 0) (white) and final (day 30)(lined) geometries for the circular (left) and elliptical wounds (right).
We also include contour plots of the oxygen (Figure 3) and MDGF (Figure 4)
concentration at different time instants. We observe how as long as the oxygen
concentration increases and the wound heals, the MDGF concentration decreases as
they are no longer needed. At the beginning of the process, there are not stresses in the
wound and as long as the wound heals and oxygen invades it the wound stresses are
higher. We have also observed that stresses around the elliptical wound are higher than
around the circular one as the elliptical wound needs higher forces to experience the
same contraction.
Fig. 3 Oxygen concentration at days 1, 3 and 10 in the circular (above) and the elliptical wound (below).
Fig. 4 MDGF concentration at days 1, 3 and 10 in the circular (above) and the elliptical wound (below).
5. DISCUSSION
Wound healing is a complex process crucial in the healing of burns and traumatic and
surgical wounds. Angiogenesis is one of the biological processes that take place during
wound healing, and it is very important as it involves the formation of new blood