ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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EVALUATING STIFFNESS DISTRIBUTIONS OF DIFFERENTIATING ADIPOCYTES USING A WIDE-FIELD DIGITAL INTERFEROMETRIC METHOD 1. ABSTRACT N. Shoham, P. Girshovitz, N.T. Shaked and A. Gefen 1 Adipocytes, which are physiologically exposed to body loads in weight-bearing adipose tissues, are recently becoming recognized as mechanoresponsive cells, with mechanical stimuli influencing both their commitment to the adipocyte phenotype and the adipogenesis process in these cells. Mechanoresponsiveness of adipocytes is relevant to understanding the connection between a sedentary lifestyle and obesity. In particular, the extent of lipid production in these cells was found to depend on the level of cellular strains. Hence, it is important to characterize the stiffness distributions of differentiating adipocytes, which directly influence the extent of cellular deformations when adipose tissues are weight-bearing. Using wide field digital interferometric microscopy, we evaluated stiffnesses of adipocytes. First, we acquired 315 interferograms at ~21 frames/s. Each interferogram was composed of interference between two beams of light originating from the same coherent laser source, where one of the beams passed through the culture and the other beam directly reached the camera. Second, the optical thickness of the cell was calculated for each interferogram. Third, temporal changes in cell optical thicknesses (optical fluctuations) were converted into an optical spring factor of the cell, which indicates on cell stiffness. The optical spring factor calculated in the cytoplasm of the adipocyte was 0.55±0.03 µN/m, significantly smaller than in the lipid areas (p
lifestyle and obesity. In that context, we have recently found that 3T3-L1 adipocyte cultures subjected to large substrate tensile strains produce intracytoplasmic lipids at a faster rate and to a larger extent (Levy et al., 2011, Shoham et al., 2011b). In another study, reduction of adipogenesis in murine stromal cells following cyclic strain was found to be magnitude dependent: loading with 2% strain resulted in partial inhibition compared to 10% strain, and loading with 0.5% strain could not inhibit adipogenesis at all (Huang et al., 2011). Combining these, the magnitude of the mechanical strain applied to the adipocytes is an important factor influencing the nature of the adipogenic response. Considering also that the stiffness of the cells directly influence on the extent of cellular deformations when adipose tissues are weight-bearing, it is important to characterize stiffness distributions of differentiating adipocytes. Stiffness of cells can be assessed using a variety of different methods, e.g. atomic force microscopy (AFM), micropipette aspiration or optical tweezers (Callies et al., 2009; Hochmuth, 2000). In the AFM, the most widely used technique, a tip is pressed against the cell surface so that the membrane is indented. This deviates the AFM cantilever which serves as a soft spring. Then a force versus deformation curve is calculated and the slope of the curve reflects the stiffness (Callies et al., 2009). The weaknesses of this technique include thermal fluctuation masking of forces that are of the order of 10-15 pN. Furthermore, the variable shape of a typical AFM probe determines the nature of the force-deformation curve (Hochmuth, 2000). In the micropipette aspiration technique, the surface of a cell is aspirated into a small tube while tracking the leading edge of its surface. Interpretation of the measurements with basic continuum models leads to values for a cell's elastic and viscous properties (Hochmuth, 2000). The drawbacks of this method include a drift in the null (zero) setting for the pressure and the demand for training and skill on the part of the experimenter (Hochmuth, 2000). The optical tweezers method imposes a controlled force and deformation on micro object using a laser light, but is generally limited to the measurement of small forces on the order of 50 pN (Hochmuth, 2000). Additionally, all of these techniques are either complex and require integrating particles in the experimental system or allow measurement of the effective stiffness of the entire cell, whereas better understanding of the adipocyte mechanics will be acquired by measuring the stiffness distribution within the cell, in its deferent regions. In this study, we introduce a novel method of nondestructive imaging and analysis of adipocyte cultures undergoing differentiation, for evaluating parametric effective stiffness properties of the cells as well as of the intracellular lipid droplets. Our results are relevant to research of adipose-related diseases, particularly overweight and obesity. 3. METHODS 3.1 Cell culturing Mouse embryonic 3T3-L1 cells (American Type Culture Collection, ATCC) were cultured in a growth medium (GM) consisting of high-glucose Dulbecco's modified eagle medium (DMEM, 4.5mg/ml; Biological Industries, Israel), 10% fetal bovine serum (FBS, Biological Industries), 1% L-glutamine (Biological Industries), 0.1% Penicillin-Streptomycin (Pen-Strep; Sigma, Israel) and 0.5% 4-(2-hydroxyethyl)-1piperazineethanesulfonic acid (HEPES; Sigma). The maximum confluence allowed for the cultures was ~80% prior to passaging. When a confluence of 90% was achieved, 2
Page 1 and 2: The Proceedings of the 10 th Intern
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Page 5 and 6: Content: POSTERS: BRAIN: CELL: EVAL
Page 7 and 8: Modeling of blood flow through a fl
Page 9 and 10: The mesh generation of the model wa
Page 11 and 12: Figure6 . The stroke volume data fo
Page 13 and 14: Digital Subtraction Phonocardiograp
Page 15 and 16: mobile cart for easy recording in c
Page 17 and 18: Figure 7. This image shows PCG samp
Page 19 and 20: Our approach is an improvement in t
Page 21 and 22: one cements as well as its behaviou
Page 23 and 24: Typical dimensions of lumbar verteb
Page 25: attributed to the change of stiffne
Page 29 and 30: T was the temperature in Kelvin and
Page 31 and 32: sustained tensile strains stimulate
Page 33 and 34: An approach aiming at determining a
Page 35 and 36: failure load. 2.4 Simulation of reh
Page 37 and 38: REFERENCES 1. Vunjak-Novakovic G, A
Page 39 and 40: 3. FIF-BAL BIOREACTOR The FIF devic
Page 41 and 42: value of p nearest to dqc=0 we cont
Page 43 and 44: (Wanless, 1999). This low value cou
Page 45 and 46: 3. MATERIALS AND METHODS A CAD mode
Page 47 and 48: did not allow gap closure. Maximum
Page 49 and 50: hand, if the IFM is too large, remo
Page 51 and 52: 2. INTRODUCTION Intervertebral disc
Page 53 and 54: Figure 3. T1 signal enhancement in
Page 55 and 56: 1. ABSTRACT TIP CELLS AT THE TOP: M
Page 57 and 58: Fig. 1. Schematic overview of the m
Page 59 and 60: Fig. 3. Image of the amount of VEGF
Page 61 and 62: THE COMPUTATIONAL MODEL OF DENTAL I
Page 63 and 64: processing application STL Model Cr
Page 65 and 66: For the implant/bone interaction as
Page 67 and 68: ABSTRACT THE IMPACT OF SELECTION BI
Page 69 and 70: Figure 1: flow chart showing the op
Page 71 and 72: Figure 2: Time course of cytosolic
Page 73 and 74: CONSTITUTIVE MODELLING OF THE ANNUL
Page 75 and 76: it is well known the non-linear nat
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Therefore, we have decided to carry
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EXTRACTION OF PHALANGEAL JOINT PARA
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column vectors of P. Denoting the v
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End i joint angles and length offse
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Validation of Strain Mapping for th
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allows the calculation of strain ma
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RMS error was 0.054 and the strains
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AN APPROACH FOR THE REDUCTION OF TH
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The relation between the time-deriv
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Error in position [mm] Error in pos
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ANALYSIS OF THE INTRAINDIVIDUAL DIF
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Fig.1: Frontal view on all subchond
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[6] M. Bozkurt, B. B. Kentel, G. Ya
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on the actual necessary time needed
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Illustration 2: The initially spher
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cell if it is hardly able to deform
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fit with a reference anatomy in min
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show that patellar mal-positioning
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Experimental and numerical analysis
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stenosis in both simulations and ex
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stented case, corresponding to the
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EVALUATION OF DIFFERENT LOADING CON
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were modeled with identical geometr
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each simulation and the position of
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FINITE ELEMENT MODEL ANALYSIS OF HU
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Figure 1: Maximal principal strains
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Method for classification of porcin
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3.3 Identification of Paths Accordi
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Table. 1. Descriptive Patterns used
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CHARACTERIZING THE MECHANICAL MICRO
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3.1.3 Cell proliferation It is assu
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Stress [Pa] 4 3 2 1 0 Mean stress A
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REFERENCES [1] A.M. Bratt-Leal, R.L
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y exposure to interstitial fluid sh
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according to (Eq. 2), nor averaged
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emoved the oscillations partially a
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static load and a dynamic load. A s
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positive effect of the number of ac
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pathways and their interactions tha
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applications, the need for accuracy
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avoid violating the initial geometr
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6. CONCLUSION The examples of appli
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Fig. 1 Semicircular canal structure
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4. RESULT Fig. 6 FSI model of semic
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6. ACKNOWLEDGEMENT This research wa
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ods to the biocompatible plastic po
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Table 1: Analysis conditions Static
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[3] Brantigan, J. W., Steffee, A. D
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femoral head fracture, the femoral
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Fig 3. Schematic drawing of the ste
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6. CONCLUSION Fig 7. Analysis resul
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and angular rates were registered b
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former, there were assumed the foll
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delivered dynamic support, which pr
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insertion of provisional restoratio
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Figure 4: Implant displacements obt
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5. DISCUSSION AND CONCLUSION Initia
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at which microdamage originates. Fo
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4. RESULTS The load response varied
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current study to explore the effect
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implant correctly from the finite e
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(a) (b) (c) (d) (e) Figure 3. The s
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(a) (b) Figure 6. The meshed model
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(a) (b) Figure 9. Cumulative probab
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NUMERICAL EVALUATION AND MEDICAL CO
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compared by overlaying the real dat
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four sample patient data, outcomes
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A POROELASTIC APPROACH FOR AN OPEN
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where indexes U, P refer to the unk
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RESULTS As a preliminary test, a 0.
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BIOMECHANICAL BEHAVIOR OF CANCELLOU
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cement acts perfectly, therefore it
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cancellous bone of natural joints a
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COMPUTATIONAL MODELING OF TANGLED A
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The centers of the simulated cells
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untangled, the local fiber displace
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TOWARDS A WAVELET BASED MEDICAL IMA
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however at each decomposition scale
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the MATLAB software (for the Modifi
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A FLUID STRUCTURE INTERACTION MODEL
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hyperelastic based on available exp
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t [ms] 30 70 160 220 270 Pressure [
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MECHANICAL BAHAVIOR OF DIFFERENT NI
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parameters necessaries to use this
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F1 and Mtwo were directly related t
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MECHANICAL EFFECT ON METABOLIC TRAN
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an initial nil lactate concentratio
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present study, such values were phe
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EVALUATION OF FEMORAL COMPONENT MIC
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TS implants employed a “hybrid”
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5. DISCUSSION i ii Figure 2: Compar
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THE MECHANICAL ENVIRONMENT IN THE D
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instead the femur was supported by
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It must be noted however, that in t
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1. ABSTRACT MODELING OF ARTICULAR C
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exp 1 1 2 1 where and are i
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Implant Fig.2. Axisymmetric represe
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A MULTI-SCALE ANISOTROPIC CONSTITUT
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3.2 Decoupled invariant formulation
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Fig. 1. Experimental data from unia
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VALIDATION AND CALIBRATION PROCESSE
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Figure 1: A three-step process simu
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The validation process employed on
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FLUID-STRUCTURE INTERACTION ANALYSI
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The coupled SQA model and the conve
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Point P7, located at the toe of the
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THE INFLUENCE OF UNCERTAIN ANATOMIC
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Figure 3 exemplifies for intradisca
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8. CONCLUSIONS Unsurprisingly, the
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COMPARISON OF DIFFERENT LOADING CON
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Figure 1 Finite element model of th
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6 CONCLUSION It is a feasible way t
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FROM CELL CONTRACTILITY TO CURVATUR
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4. MODEL When cells adhere on a sub
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organisation. Understanding the pri
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PREOPERATIVE PLANNING SUPPORT SYSTE
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[9]. Stenosis of 25, 45, 65 and 85
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Fig. 1:Dependent and independent va
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1. ABSTRACT Local strain measuremen
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around 100µm (halfway through the
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sampling points at different cross
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CLASSIFICATION OF PHYSICAL ACTIVITY
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induces a vertical alignment of the
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accelerations combination). However
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line under translation. Information
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In this study, we apply a meshless
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used the PAC constitutive constants
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1006031) is gratefully acknowledged
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improvements were seen in both grou
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Pre-augmentation Position 1, V=3mL
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5. ACKNOWLEDGEMENTS Funding for thi
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the hemodynamics in cerebral aneury
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4. RESULTS AND DISCUSSION In order
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processing methods need to be devel
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3. METHODS 3.1 Experimental Method
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Figure 2 - Micrographs for tensile
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analysis of the tissue mechanics. B
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3. METHODS 3.1 Specimen Preparation
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of five points across the mid mid-c
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equired to replicate the deformatio
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pre-load within the plate (compress
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4. RESULTS The load-deformation beh
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fracture fixation. Medical Engineer
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model. It approximates knee kinemat
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computational cost remains moderate
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Concerning the optimization procedu
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aesthetic recovery. However, in som
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atio experimented by both wounds is
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VARIATION OF MICRO-ARCHITECTURE AND
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osteoporotic (OP). The sample volum
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Figure 4: Mean error in orthotropy
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INVESTIGATION OF CORTICAL SHELL STR
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When creating the degenerated FE mo
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Figure 4. Degeneration sensitivity
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METHODS TO ACCELERATE FINITE ELEMEN
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the “joint” constraints configu
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Figure 4: Absolute prediction error
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EFFECT OF POST TREATMENT FOR MULTIP
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Fig.2 Inlet velocity profile indica
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4.3 WSS results Figure 8 shows the
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approximated by the so-called Ritz
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Figure 2: Viscohyperelastic cube: (
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There is no optimal density-elastic
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Fig. 2 Cut view of FE-model. Shown
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5. Weis JA, Miga MI, Granero-Moltó
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3. SYSTEM DESIGN Sheep eyes, as the
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which provides natural tactile feed
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113:341-342 20. Henderson B. A., Gr
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health area. According to estimates
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Table 1. RMS Value based on subject
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6. REFERENCES 1. http://www.disable
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ehavior [5]. From the viewpoint of
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Fig. 1 Average Male and Female's L4
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4. Deyo, R.A., and Weinstein, J. N.
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geometry of the cell and ECM degrad
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Shown in Fig. 2(b) is a plot of the
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6. REFERENCES 1. Dubin-Thaler B.J.,
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We implemented our individual-based
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3.3.1 Centers of mass Table 1: Base
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average coordination num ber averag
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BIOMECHANICAL ANALYSIS OF THE MUSCU
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of the ligament strain; a linear re
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lengthening, respectively, if compa
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THE EFFECT OF HIGH TIBIAL OSTEOTOMY
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The 3D LiveWire tool was used as an
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Table II: Peak medial and lateral f
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INVESTIGATING CHANGES IN JOINT LOAD
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4. RESULTS Table 1 shows the mean m
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Fig.5 displays the OKS and KOS pre
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Dynamic Touch of Effective Golf Swi
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properties of a golf club and hand
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perturbation in e3 whereas player B
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1. Kim, W., Response to letter to t
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configuration.[4] have explained ho
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compartments as well as a single mu
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5. Shabana, A.A., Dynamics of multi
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Five healthy volunteers (age: 38.3
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internal lumbar spinal shape was de
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Airflow Simulation of Nasal Cavity
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temperature [5], and Wbl is the wat
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Figure 8. Figure 8(a) illustrates t
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Finite element models of the hip ca
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3.2 Finite Element Analysis Followi
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5. DISCUSSION Previous DEA implemen
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STATISTICAL SHAPE MODELING OF CAM-T
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Thirty-three control femurs (25 mal
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asymptomatic subjects 7,9 . The Hot
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6. REFERENCES 1. Ganz, R., Parvizi,
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NUMERICAL IDENTIFICATION OF THE PER
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2. METHOD AND NUMERICAL MODEL. 2.1
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1 u dV V u. (Eq. 2) V The permeab
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1. ABSTRACT PASSIVE AND ACTIVE MUSC
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presented in figure 2 the simulatio
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Indenter Stroke [mm] Muscle Force [
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Objectives Long bone failure charac
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the specimens in three point bendin
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developing a subject-specific finit
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Models used in the past, mostly bas
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In this work it is presented the de
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Average Table 1.- Walk average test
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angles for the step of 2.28° and 8
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insufficiency syndrome (TIS), defin
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a) b) c) Fig. 5 - Contact interface
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EOS. Among these options, VEPTR has
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dissection occurs when blood intrud
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mean value of 0.0310 m s -1 . The o
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progression. It can in turn contrib
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dependent data. They conclude that
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found that it is extremely difficul
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endering loop is started and the ra
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3.1 Imaging protocol of the knee A
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Fig. 3: Pressure distribution in th
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7. REFERENCES 1. Masouros, S.D., Bu
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and estimate in vivo tissue strains
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tendon has a larger moment arm abou
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Song, H. M., Smith, R. L., Longaker
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Fig. 1. Single line transducer resu
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Let P INT be the data set of the lo
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could quantify the initial structur
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expansion of a stent, a metallic sc
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immediately after stent expansion a
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6. ACKNOWLEDGMENT This research is
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Deformation of the arterial surface
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separate study to be described in a
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3. Timmins, L.H., Miller M.W. Clubb
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migrate in a unique fashion to the
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Fig. 1: Domain and schematic repres
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Furthermore, the values are spread
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this study, our goal is to establis
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Figure 3. Relative length change in
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5. Erdemir A, Sibole S. Open Knee:
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lateralis (inferior and superior) f
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during mouth closing and chewing. O
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BIOMECHANICAL MODELING OF THE HUMAN
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appropriates mechanical properties
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Fig. 4: Correlation of the location
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1. ABSTRACT COMPUTER AIDED TUMOR RE
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B. Cutting planes The surgeon defin
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4.RESULTS To test the developed sys
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FROM PATIENT-SPECIFIC DATA TO MULTI
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catheterization mean measurements (
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the different virtual surgical desi
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1. ABSTRACT DIGITAL ULTRASOUND DESP
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2.2 Filtering Based Wavelet 2.2.1 C
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Table 1: quantitative criteria used
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Mural Thrombosis in a Two-Level Com
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But, the soft repulsive force can n
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Ratio of adhered PLT a simplificati
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DEGRADATION OF MAGNESIUM ALLOY STEN
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study and the parameter setting can
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Fig. 5. Damage evolution of the thr
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NUMERICAL SIMULATIONS OF FATIGUE FO
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Figure 1. Scheme of the two approac
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Figure 3. On the left, alternating
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INVESTIGATION OF HEAD-NECK KINEMATI
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complexity of the vertebrae and sku
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nearly no tension occurred for the
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9. Ito S, Ivancic PC, Panjabi MM, C
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[Ntsinjana et al., 2011], commonly
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impedances were maintained within p
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6. Pennati G., Corsini C., Cosentin
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analyse the effect that different a
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attached cases this value was highe
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References 1. Nordin M and Frankel
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therapy to achieve the desired medi
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iomechanical response of the leg to
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algorithm has to be integrated into
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to a modification in the tooth disp
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5. CONCLUSIONS 5.1 Geometry and per
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present work is to show the ability
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[6,7]. In order to reproduce numeri
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5. DISCUSSION, CONCLUSIONS AND PERS
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3.1 Generation of the vertebral sur
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3.4 Modeling of the facet joints Th
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The column diagramm of Fig.8 shows
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tool to evaluate the drug distribut
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Figure 3: The mean value of the dos
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INFLUENCE OF KYPHOSIS ON SPINAL LOA
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(a) (b) (c) Fig. 1. The three repre
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etween T6 and T9 with a higher degr
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A COMPARISON BETWEEN STANDARD AND D
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the SB with a 2.5 mm balloon; ii) o
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A TAWSS [Pa] B OSI [Pa] C 0 0.25 0.
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ABSTRACT CONSTITUTIVE MODELLING OF
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20% compression strains were impose
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4. DISCUSSION The limited number of
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AN ALGORITHM FOR MODELING THE FIBRE
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1 - Compute the centre of the botto
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(a) (b) Figure 2. Load-displacement
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A bio-mechanics based methodology t
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to a particular body part based on
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Injury Cost (USD) Million 0.7 0.6 0
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A SENSITIVITY ANALYSIS OF ADAPTIVE
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elationships can be found that rela
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Fig. 2: Percentage of bone volume w
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APPLICATION OF REACTION-DIFFUSION W
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AIRFLOW VENTILATION THROUGH HUMAN M
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solve all the governing equations.
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Fig. 4 Streamlines through the osti
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MOLECULAR DYNAMICS SIMULATIONS FOR
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COARSE-GRAINED MOLECULAR DYNAMICS S
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DESIGN AND STRUCTURAL EVALUATION OF
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Figure 2 shows the optimal unit-cel
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ENUM (MPa) 100 90 80 70 60 50 40 30
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vivo menisco-tibial kinematics duri
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Loading the fully extended knee wit
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is also subject to variation due to
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environment in comparison to fixed
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4. RESULTS AND DISCUSSION Convergen
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Because of the orthotropic assumpti
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3D RECONSTRUCTION OF STENTED PORCIN
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Fluid model. The final configuratio
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Table 1: Computed slice measurement
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ANALYSIS OF THE EFFECT OF CONSIDERI
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For all these models, C1 = µ/2, µ
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the difference in percentage betwee
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A COMPUTATIONAL METHOD TO ESTIMATE
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C10, C01 and d were taken from [10]
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4. RESULTS Fig. 2 shows the results
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COMPUTATIONAL AND EXPERIMENTAL MODE
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data using commercial software (Mim
Page 769 and 770:
vitro (40 vs 34%), at the expense o
Page 771 and 772:
FINITE ELEMENT ANALYSES OF IN VIVO
Page 773 and 774:
The non-linear behaviour of the art
Page 775 and 776:
Figure 6. Constant-life diagram for
Page 777 and 778:
Optimal acceleration adjustment to
Page 779 and 780:
, , , ,
Page 781 and 782:
The vertical force bump observed du
Page 783 and 784:
NEURAL NETWORK-BASED PREDICTION OF
Page 785 and 786:
3. MATERIAL AND METHODS 3.1 Experim
Page 787 and 788:
from subjects S1, S2, S3, S5, and S
Page 789 and 790:
APPLICATION OF A MODIFIED ELASTIC F
Page 791 and 792:
h and h being the thickness of the
Page 793 and 794:
0.3 were used for the flat surface
Page 795 and 796:
simulations of the mechanical respo
Page 797 and 798:
50000 images have been acquired. Th
Page 799 and 800:
Fig.1 Modules of the proposed capsu
Page 801 and 802:
5. CONCLUSION This paper describes
Page 803 and 804:
dependent on the implementation of
Page 805 and 806:
joint computer model was driven wit
Page 807 and 808:
otation. The AP laxity test showed
Page 809 and 810:
A COMPUTATIONAL MODEL OF THE GROWTH
Page 811 and 812:
where n p is the number of prolifer
Page 813 and 814:
Hypertrophic columnar cartilage 0.2
Page 815 and 816:
SIMULATION OF DAILY LIVING MOVEMENT
Page 817 and 818:
otations were kept at zero, since t
Page 819 and 820:
cavity (van der Helm, 1994). Howeve
Page 821 and 822:
Solving Overconstrained Kinematic i
Page 823 and 824:
3.3. Muscles Muscles are modelled a
Page 825 and 826:
5. DISCUSSION A musculoskeletal num
Page 827 and 828:
EFFECT OF OSCILATORY FLOW ON MORPHO
Page 829 and 830:
dimensionless frequency . With the
Page 831 and 832:
Wntsignaling, J Clin Invest., 2006,
Page 833 and 834:
Maximization (EM) algorithm witch e
Page 835 and 836:
4. RESULTS: n 1 2 x f ( x ; )
Page 837 and 838:
5. CONCLUSION In this work, a semi-
Page 839 and 840:
allow cell construct image inspecti
Page 841 and 842:
formula can be written as a linear
Page 843 and 844:
( ) (4) Poisson‟s ratio was assum
Page 845 and 846:
a) b) c) d) Figure 7 Validation: a)
Page 847 and 848:
DEVELOPMENT OF A NEW COMPUTATIONAL
Page 849 and 850:
The ScanIP wizard creates the new i
Page 851 and 852:
Fig. 5: Computer experiments: poste
Page 853 and 854:
A BIOMECHANICAL CONCEPT FOR CONSTRU
Page 855 and 856:
Figure 3. Construction of the radia
Page 857 and 858:
6. REFERENCES 1. Lees, S., A study
Page 859 and 860:
from cadaver surgeries were recreat
Page 861 and 862:
mean resection parameters and the p
Page 863 and 864:
5. DISCUSSION This study proposes a
Page 865 and 866:
simulations are evaluated by quanti
Page 867 and 868:
improvement of the shoulder prosthe
Page 869 and 870:
13. Coley B., Jolles B. M., Farron
Page 871 and 872:
simulations. Implicit in this setup
Page 873 and 874:
assigned zero fluid pressure bounda
Page 875 and 876:
the efficacy of predicting cellular
Page 877 and 878:
Another important function of the l
Page 879 and 880:
The insert (Fig. 3) is the part aga
Page 881 and 882:
changes due to the testing conditio
Page 883 and 884:
3. IN VIVO MEASURED LOAD COMPONENTS
Page 885 and 886:
anthropometric data - a data set fo
Page 887 and 888:
COMPUTATIONAL MODELING OF HIGHLY PO
Page 889 and 890:
objects smaller than one tenth of a
Page 891 and 892:
as 221.5 MPa. This value is more th
Page 893 and 894:
Macrostress and Macrostrain Finite
Page 895 and 896:
3.2. Extraction of individual artic
Page 897 and 898:
Unique strain patterns were observe
Page 899 and 900:
poroviscoelastic simulation of the
Page 901 and 902:
anchorage of the cartilage into a p
Page 903 and 904:
load of 0.5 N) resulted in a 55 kPa
Page 905 and 906:
properties as well as protect the h
Page 907 and 908:
Dynamic cell seeding combines two c
Page 909 and 910:
order (PB). The particles adhered (
Page 911 and 912:
2. D. Wendt, A. Marsano, M. Jakob,
Page 913 and 914:
2. Only a few high-level clinical s
Page 915 and 916:
A quasi-static analysis was perform
Page 917 and 918:
e increased by using stiffer or tig
Page 919 and 920:
Despite the importance of taking th
Page 921 and 922:
Table 2: Score chart presented to t
Page 923 and 924:
We conclude that the model develope
Page 925 and 926:
presented system - parallelization
Page 927 and 928:
image is projected to the subsequen
Page 929 and 930:
6. CONCLUSIONS The presented in the
Page 931 and 932:
first simulation uses data provided
Page 933 and 934:
Table 1: Models used in this study.
Page 935 and 936:
direction at knee extension, placin
Page 937 and 938:
3. METHODS 3.1. Model of heat trans
Page 939 and 940:
condition before and after heating.
Page 941 and 942:
during daily activities reported in
Page 943 and 944:
samples of brain tissue were extrac
Page 945 and 946:
5. DETERMINING MECHANICAL PROPERTIE
Page 947 and 948:
2001, Vol. 38 (4), 335-345. 8. Vela
Page 949 and 950:
chamber [4]. After obtaining the va
Page 951 and 952:
4. RESULTS 4.2 Surface and solid me
Page 953:
7. ACKNOWLEDGMENTS Financial fundin
Page 956 and 957:
affect crack penetration into osteo
Page 958 and 959:
Therefore, in order to examine the
Page 960 and 961:
3. Mischinski, S., Ural, A., 2011,
Page 962 and 963:
esearchers. The power of a finite-e
Page 964 and 965:
figure 2, we can determine the node
Page 966 and 967:
architecture, Muscle & Nerve, 2004,
Page 968 and 969:
ensure good short-term and long-ter
Page 970 and 971:
Table I - Micromotion results at th
Page 972 and 973:
COMBINED BONE-IMPLANT FIXATION: A P
Page 974 and 975:
FRICTIONAL PROPERTIES OF OSTEOARTHR
Page 976 and 977:
With the following boundary conditi
Page 978 and 979:
pressures higher than normal contac
Page 980 and 981:
1. ABSTRACT DYNAMIC PRESSURE RESPON
Page 982 and 983:
quasi-static solution, and both pos
Page 984 and 985:
(excluding the cadaveric validation
Page 987 and 988:
AN ANALYTICAL MODEL TO INVESTIGATE
Page 989 and 990:
K sh = 2. 3E sh 2 ( ) 2 1 2 1−ν
Page 991 and 992:
Fig. 7 modeling the oblique impact
Page 993 and 994:
A NON-LINEAR BIPHASIC MODEL FOR THE
Page 995 and 996:
system, it is convenient to write t
Page 997 and 998:
only with very small damping parame
Page 999 and 1000:
A PARAMETERIZED FE MODEL FOR SIMULA
Page 1001 and 1002:
the study of Polikeit et al. [10].
Page 1003 and 1004:
There are obvious limitations to ou
Page 1005 and 1006:
Abnormal stresses are often cited a
Page 1007 and 1008:
4. RESULTS The methods used to meas
Page 1009 and 1010:
that muscle imbalance associated wi
Page 1011 and 1012:
BIOCHEMICAL MODEL TO PREDICT THE ON
Page 1013 and 1014:
3.1 Model description The regulator
Page 1015 and 1016:
[3] Shier D., 2001, Hole’s Human
Page 1017 and 1018:
Biomechanics of Human Gluteal Tissu
Page 1019 and 1020:
information. Based on the indentati
Page 1021 and 1022:
t 1 ⎧⎪ ⎫ 2 2 ⎪ ττττ ( t
Page 1023 and 1024:
REFERENCES 1. Gefen A., Gefen N., L
Page 1025 and 1026:
analysis of the large-scale human m
Page 1027 and 1028:
λ σ = σ (8) act isom f f 0 ⋅
Page 1029 and 1030:
In the absence of membranes, the mu
Page 1031 and 1032:
predicted. This is possible for mod
Page 1033 and 1034:
-7.2 mN. The average value of the m
Page 1035:
efore the joint moment reaches zero
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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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