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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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Figure 3: The mean value of the dose, namely dw(V) = V −1 M(d w ,V), quantified over the regions<br />

VTOT , VMBP , VMBD and V from left to right, top to bottom.<br />

SB<br />

First, the drug dosage provided to the SB when the one-stent procedure is performed is<br />

only due to drug convection from the lumen of the MB to the SB. Such amount of drug<br />

does not seem to be adequate to provide a significant drug supply to the SB regions in<br />

order to avoid re-stenosis.<br />

Concerning the proximal region of the MB we observe a higher dose in the case of the<br />

double-stent procedure. Nevertheless, the drug dosage in the case C is not doubled with<br />

respect to PSB (stent surface in case C is 2 times stent surface in PSB) but it is only<br />

about 3/2 larger. This finding is mainly due to the significant amount of drug charge<br />

that is washed out in the blood stream where stent struts overlap. Compared to the case<br />

of idealized strut apposition, the amount of drug loss in realistic configurations can be<br />

quantified by the incremental part (Fig. 3, light grey) of the bar plots.<br />

5. ACKNOWLEDGEMENT<br />

All the authors have been supported by the Grant Nanobiotechnology: Models and<br />

methods for degradable materials of the Italian Institute of Technology (IIT). The<br />

authors E. Cutri' and P. Zunino are also supported by the European Research Council<br />

Advanced Grant Mathcard, Mathematical Modelling and Simulation of the<br />

Cardiovascular System, Project ERC-2008-AdG 227058. Francesco Migliavacca,<br />

Stefano Morlacchi and Claudio Chiastra are partially supported by the project “RT3S-<br />

Real Time Simulation for Safer vascular Stenting” funded by the European Commission<br />

under the 7th Framework Programme, GA FP7-2009-ICT-4-248801.

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