abstracts - Институт катализа им. Г.К. Борескова

PL-5A combination of homogeneous and heterogenous catalysts has been used to facilitate theone-pot synthesis of the fungicide Fenpropimorph via a Heck reaction or an aldolcondensation and then a reductive amination reaction. 18 Although both Heck and aldolprocesses proceed efficiently in the ionic liquid only the aldol pathway may be recycled. Byusing the amine catalyst from the aldol condensation as the reagent in the subsequentreductive amination reaction a highly atom efficient process is possible. A versatile multistepcatalytic synthesis using a single ionic liquid is possible with the ionic liquid able to be easilyrecycled. In contrast using conventional molecular solvents, the separation is more difficultand requires evaporation and recondensation of the solvent.References:1 M. Freemantle, Chem. Eng. News 1998, 76, 32 March 30; J. D. Holbrey andK. R. Seddon, Clean products and processes I, 1999, 223.2 C. E. Song, W. H. Shim, E. J. Roh and J. H. Chio, Chem. Commun., 2000, 1695.3 C. J. Mathews, P. J. Smith and T. Welton, Chem. Commun., 2000, 1249.4 A. J. Carmichael, M. J. Earle, J. D. Holbrey, P. B. McCormac and K. R. Seddon, Org.Lett., 1999, 1, 997.5 C. deBellefon, E. Pollet and P. Grenouillet, J. Mol. Catal., 1999, 145, 1216 A. J. Carmichael, D. M. Haddleton, S. A. F. Bon and K. R. Seddon, Chem. Commun.,2000, 1237.7 M. F. Pinheiro, R. S. Mauler, R. F. deSouza, Macromol. Rapid. Commun., 2001, 22, 425.8 C. Hardacre, J. D. Holbrey, S. P. Katdare and K. R. Seddon, Green Chem., 2002, 4, 143.9 Y. Chauvin, L. Mussman and H. Olivier, Angew. Chem. Int. Ed. Engl., 1995, 34, 2698.10 P. J. Dyson, D. J. Ellis and T. Welton, Can. J. Chem., 2001, 79, 705; P. J. Dyson,D. J. Ellis, D. G. Parker and T. Welton, Chem. Commun., 1999, 25.11 P. W. N. M. vanLeeuwen, P. C. J. Kamer, J. N. H. Reek and P. Dierkes, Chem. Rev.,2000, 100.12 D. Zim, R. F. deSouza, J. Dupont and A. L. Monteiro, Tet. Lett., 1998, 39, 7071.13 For example, T. Welton, Chem. Rev., 1999, 99, 2071, C. M. Gordon, Appl. Catal., 2002,A222, 101; D. Zhao, M. Wu, Y. Kou, and E. Min, Catal. Today, 2002, 1, 2654;R. Sheldon, Chem. Commun., 2001, 2399; J. Dupont, R. F. de Souza and P. A. Z. Suarez,Chem. Rev., 2002, 102, 3667; Ionic Liquids in Synthesis, ed. T. Welton andP. Wasserscheid, Wiley-VCH: Weinheim, 2003.14 S. Doherty, P. Goodrich, C. Hardacre, H.K. Luo, D.W. Rooney, K.R. Seddon andP. Styring Green Chem. 2004, 6, 63.15 K. Anderson, P. Goodrich, C. Hardacre, D.W. Rooney, Green Chem., 2003, 5, 448.16 C. Hardacre, S.P. Katdare, D. Milroy, P. Nancarrow, D.W. Rooney and J.M. Thompson,J. Catal., 2004, 227, 44.17 M.J. Earle, U. Hakala, C. Hardacre, J. Karkkainen, B.J. McAuley, D.W. Rooney,K.R. Seddon, J.M. Thompson and K. Wahala, Chem. Commun., 2005, 903.18 P.N. Davey, S.A. Forsyth, H.Q.N. Gunaratne, C. Hardacre, A. McKeown, S.E.J. McMath,D.W. Rooney, K.R. Seddon, Green Chem., 2005, 7, 224; S.A.Forsyth, H.Q.N. Gunaratne,C. Hardacre, A. McKeown and D.W. Rooney, Org. Proc. Res. Dev., 2006, 10, 94.17