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Review of Pharmacology - 9E (2015)

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Autacoids<br />

Drug <strong>of</strong> choice<br />

Condition<br />

Drug <strong>of</strong> choice<br />

• Migraine<br />

– Acute-mild to modrate NSAIDs<br />

– Acute-severe Sumatriptan<br />

– Prophylaxis Propanolol<br />

• Abortion < 7 weeks<br />

Mifepristone + misoprostol<br />

• Induction <strong>of</strong> labour<br />

Oxytocin<br />

• Post-partum hemorrhage<br />

Oxytocin<br />

• Cervical priming<br />

Misoprostol<br />

• NSAID-induced peptic ulcer<br />

Proton pump inhibitors<br />

• Open angle glaucoma<br />

Latanoprost<br />

• To maintain patency <strong>of</strong> ductus arteriosus Alprostadil<br />

• Treatment <strong>of</strong> patent ductus arteriosus (PDA) Indomethacin<br />

• Bartter syndrome<br />

Indomethacin<br />

• Pulmonary hypertension<br />

Oral diltiazem or amlodipine or nifedipine<br />

• Erectile dysfunction<br />

Sildenafil<br />

• Rheumatoid arthritis<br />

– Pain relief NSAIDs<br />

– Bridge therapy Corticosteroids<br />

– DMARD Methotrexate<br />

• Flushing due to nicotinic acid<br />

Aspirin<br />

• Prophylaxis <strong>of</strong> MI and stroke<br />

Aspirin<br />

• Acetaminophen (Paracetamol) poisoning N-Acetyl cysteine<br />

• Anaphylactic shock<br />

Adrenaline<br />

• Acute mediterranean fever<br />

Colchicine<br />

• Cancer chemotherapy induced vomiting 5HT 3<br />

antagonists like ondansetron<br />

• Cisplatin induced vomiting<br />

– Early Ondansetron<br />

– Delayed Aprepitant<br />

• Gout<br />

– Acute NSAIDs except aspirin<br />

– Refractory acute Colchicine<br />

– Chronic Allopurinol<br />

– Chronic (in patient allergic to allopurinol) Febuxostat<br />

• Hyperuricemia secondary to anticancer drugs Allopurinol<br />

General Autacoids <strong>Pharmacology</strong><br />

125<br />

https://kat.cr/user/Blink99/

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