Review of Pharmacology - 9E (2015)

Central Nervous System
344
Review of Pharmacology
31. Which of the following if combined with rivastagmine,
decreases its efficacy? (AI 2010)
(a) Selective serotonin reuptake inhibitors
(b) Reversible inhibitor of MAO-A
(c) Tricyclic antidepressants
(d) Atypical antidepressants
32. All of the following statements about trientine use in
Wilson’s disease are true except:
(a) It is more potent than penicillamine.
(b) It is used as an alternative to penicillamine in nontolerant
patients (AI 2010)
(c) It should not be administered within 2 hours of iron
supplementation.
(d) It can cause iron def anemia which is reversible by
oral iron supplements
33. Which of the following agents enhances the
bioavailability of levodopa in patients with Parkinson’s
disease:
(a) Amantadine (DPG 2009)
(b) Ropinirole
(c) Entacapone
(d) Selegiline
34. All the following statements regarding levodopa are
correct EXCEPT: (AI 2004)
(a) In Parkinsonism, phenothiazines reduce its efficacy
(b) It is a prodrug
(c) Pyridoxine reduces effect of levodopa in Parkinsonism
(d) Domperidone blocks levodopa induced emesis and
its therapeutic potential.
35. A patient of Parkinsonism is managed with levodopa.
If Vitamin B complex is administered concurrently to
the patient: (AI 2000)
(a) The action of levodopa in brain will be potentiated
(b) Decarboxylation of l-dopa in brain will be decreased
(c) Side effects will be ameliorated
(d) Decreased efficacy will result
36. Ropinirole is most useful for the treatment of:
(a) Parkinson’s disease (AIIMS Nov, 2004)
(b) Wilson’s disease
(c) Hoffmann syndrome
(d) Carpal tunnel syndrome
37. Which of the following statements is FALSE regarding
drugs used in the treatment of Parkinsonism?
(a) Amantadine causes ankle edema (AIIMS Nov, 2002)
(b) Levodopa is effective in reducing tremors
(c) Amantadine is more effective than levodopa
(d) Anti-muscarinic agents are effective in drug induced
Parkinsonism
38. Drugs used for treatment of Parkinson’s disease include:
(PGI June, 2003)
(a) Levodopa
(b) Mazindol
(c) Bromocriptine
(d) Acyclovir
(e) Benserazide
39. Drugs causing parkinsonism include: (PGI Dec. 2001)
(a) Bromocriptine
(b) Phenothiazine
(c) Haloperidol
(d) Amantadine
(e) Carbidopa
40. Entacapone may be useful in patients being treated
with levodopa-carbidopa combination because it:
(a) Activates COMT
(b) Decreases formation of 3-OMD
(c) Inhibits monoamine oxidase type B
(d) Inhibits dopamine uptake
41. Which of the following adverse effects of levodopa is
not minimized even after combining it with carbidopa?
(a) Involuntary movements
(b) Nausea and vomiting
(c) Cardiac arrhythmia
(d) ‘On-off’ effect
42. Which of the following antiparkinsonian drugs directly
activates dopaminergic D 2
receptors in the striatum?
(a) Pramipexole
(b) Entacapone
(c) Benserazide
(d) Selegiline
43. Which of the following statements about donepezil is
CORRECT?
(a) It is a topical carbonic anhydrase inhibitor used in
glaucoma
(b) It is a catechol-o-methyl transferase inhibitor used as
an adjuvant in Parkinson’s disease
(c) It is a cerebroselective anticholinesterase that affords
symptomatic improvement in Alzheimer’s disease
(d) It is a synthetic cannabinoid with antiemetic property
44. Which statement is correct about pramipexole?
(a) Activates brain dopamine receptors
(b) Commonly a first line therapy for Parkinson’s
disease
(c) Not an ergot derivative
(d) All of the above
45. Entacapone is an anti-Parkinsonism drug. It acts by:
(a) Agonism at dopamine receptors
(b) Antagonism at dopamine receptors
(c) Monoamine oxidase inhibition
(d) Cathecol-o-methyl transferase inhibition.
46. A compound X decreases the functional activities of
several CNS neurotransmitters including dopamine,
adrenaline and serotonin. At high doses it may cause
Parkinsonism like extrapyramidal system dysfunction.
Which of the following can be X?
(a) Baclofen
(b) Diazepam
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