Review of Pharmacology - 9E (2015)

General Pharmacology
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Review of Pharmacology
189. In which of the following phases of clinical trials,
healthy normal human volunteers participate:
(a) Phase-I (MPPG 2003)
(b) Phase-II
(c) Phase-III
(d) Phase-IV
190. There are some undesirable but unavoidable pharmacodynamic
effects of a drug, which are known as:
(a) Toxic effects (MPPG 2002)
(b) Idiosyncrasy
(c) Side effects
(d) Intolerance
191. The aim of post-marketing studies is: (UP 2005)
(a) Efficacy of the drug
(b) Dosage of the drug
(c) Deals with alteration of the drug includes absortion,
distribution, binding/storage
(d) Safety and comparisons with other medicines
192. In which phase of clinical trials, post-marketing
surveillance of a drug is carried out: (MP 2008)
(a) Phase I
(b) Phase II
(c) Phase III
(d) Phase IV
Miscellaneous
193. Type A (augmented) adverse drug reactions are characterized
by all EXCEPT: (Karnataka 2007)
(a) Qualitatively abnormal responses to the drug
(b) Predictable from the drug’s known pharmacological
or toxicological effects
(c) Generally dose-dependent
(d) Usually common
194. In pregnancy, all of the following drugs are contraindicated
except: (AIIMS May 2011)
(a) ACE Inhibitors
(b) Angiotensin Receptor Blockers
(c) Proplythiouracil
(d) Thalidomide
195. A newborn baby was born with phocomelia. It results
due to which drug taken by mother during pregnancy?
(a) Tetracycline (AIIMS Nov 2010)
(b) Thalidomide
(c) Warfarin
(d) Alcohol
196. Which of the following drugs can be given safely in
pregnancy: (AI 2009)
(a) Propylthiouracil
(b) Methotrexate
(c) Warfarin
(d) Tetracycline
197. All of the following drugs undergo hepatic metabolism
before excretion except: (AI 2002)
(a) Phenytoin
(b) Diazepam
(c) Penicillin G
(d) Cimetidine
198. All the following drugs can cross placenta except:
(a) Phenytoin (AI 2002)
(b) Diazepam
(c) Morphine
(d) Heparin
199. All are reasons for alteration of drug dosage in the
elderly except: (AI 2001, AIIMS May 2002)
(a) They have decreasing renal function with age
(b) They are lean and their body mass is less
(c) Have increased baroreceptor sensitivity
(d) Body water is decreased
200. True about the teratogenicity of a drug is all except:
(a) Characteristic set of malformations indicating
selectivity for certain target organs is seen (AI 2000)
(b) Heparin is highly teratogenic drug
(c) Related to the dose of the teratogenic drug
(d) Affects specifically at a particular phase of
development of the fetus
201. Side effects of a drug arise due to interactions of the
drug to molecules other than the target. These effects of
the drug can be minimized by its high:
(a) Specificity (AIIMS Nov., 2005)
(b) Solubility
(c) Affinity
(d) Hydrophobicity
202. Receptor mediated action is not seen in: (PGI June, 2004)
(a) Alcohol
(b) Antipsychotic
(c) Antacids
(d) Benzodiazepines
(e) Propofol
203. Blood brain barrier is crossed by: (PGI Dec. 2002)
(a) Dopamine
(b) Propanolol
(c) Glycopyrrolate
(d) Physostigmine
(e) Streptomycin
204. Drugs that can be safely given in pregnancy are:
(a) Antifolate (PGI Dec. 2002)
(b) Quinine
(c) Chloroquine
(d) Primaquine
(e) Tetracycline
205. Which of the following drugs are secreted in breast
milk? (PGI June, 2001)
(a) Antihistaminics
(b) Antithyroid drugs
(c) Penicillins
(d) Diazepam
(e) Antiepileptics
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