Review of Pharmacology - 9E (2015)

(c) Physostigmime
(d) Hyoscine hydro bromide
65. All of the following are actions of muscarinic
antagonists except: (AI 2011)
(a) Decreases gastric secretion
(b) Prolongs A-V conduction
(c) Decreases tracheobronchial secretions
(d) Causes contraction of radial muscle of iris
66. Which of the following drug is used for overactive
bladder? (AIIMS Nov 2010)
(a) Duloxetine
(b) Darifenacin
(c) Oxybutynin
(d) Flavoxate
67. A patient presented in emergency with tachycardia,
hyperthermia, bronchial dilatation and constipation.
The person is likely to be suffering from overdose of:
(a) Atropine (AIIMS Nov 2010)
(b) Organophosphorus compound
(c) Mushroom
(d) Paracetamol
68. A child presented with history of ingestion of some
unknown plant and developed mydriasis, tachycardia,
dry mouth, warm skin and delirium. Which of the
following group of drugs is likely to be responsible for
the symptoms of this child? (AIIMS May 2010)
(a) Anticholinergic
(b) Sympathomimetic
(c) Opioid
(d) Benzodiazepine
69. Which of the following drug is commonly used in
narcoanalysis? (AI 2010)
(a) Atropine sulfate
(b) Scopolamine hydrochloride
(c) Phenobarbitone
(d) Morphine
70. All of the following drugs are useful in detrussor
instability except: (AIIMS Nov 2008)
(a) Solefenacin
(b) Tolterodine
(c) Flavoxate
(d) Duloxetine
71. Botulinum toxin blocks neuromuscular transmission
by which of the following mechanism: (DPG 2009)
(a) Closure of Ca ++ channels at presynaptic membrane
(b) Closure of Na + channels at the postsynaptic membrane
(c) Opening of K + channels at the presynaptic membrane
(d) Opening of Cl – channels at the postsynaptic membrane
Autonomic Nervous System
72. Botulinum toxin produces skeletal muscle paralysis
by: (DPG 2009)
(a) Enhancing release of norepinephrine
(b) Inhibiting release of acetylcholine
(c) Direct damage to nerve endings
(d) Producing hemolysis
73. Use of tiotropium is contra-indicated in: (AI-2008)
(a) Bronchial asthma
(b) Hypertension
(c) Urinary retention
(d) Peptic ulcer disease
74. All of the following drugs are used for the treatment of
urinary incontinence except:
(AI-2008)
(a) Oxybutynin
(b) Ipratropium
(c) Darifenacin
(d) Tolterodine
75. Drug of choice for mushroom poisoning is: (AI 2007)
(a) Atropine
(b) Physostigmine
(c) Adrenaline
(d) Carbachol
76. Which of the following drugs increases gastro-intestinal
motility? (AI 2005)
(a) Glycopyrrolate
(b) Atropine
(c) Neostigmine
(d) Fentanyl
77. Which one of the following drugs does not produce
central anticholinergic syndrome? (AIIMS Nov, 2005)
(a) Atropine sulphate
(b) Glycopyrrolate
(c) Antihistaminics
(d) Tricyclic antidepressants
78. Atropine can cause: (PGI Dec. 2001)
(a) Decreased cardiac output
(b) Heart block
(c) Hypertension
(d) Mydriasis
(e) Sweating
79. Intramuscular injection of atropine causes initial
bradycardia. The reason for this effect being seen is:
(a) Stimulation of medullary vagal centre
(b) Stimulation of vagal ganglia
(c) Blockade of M 2
receptors of SA nodal cells
(d) Blockade of muscarinic autoreceptor on vagal nerve
endings
80. The difference between hyoscine and atropine is that
hyoscine:
(a) Exerts depressant effects on the CNS at relatively
low doses
(b) Exerts more potent effects on the heart than on the
eye
81
Autonomic General Pharmacology
Nervous System
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