Review of Pharmacology - 9E (2015)

Review of Pharmacology
Chemotherapy C: Antineoplastic Drugs
85. All are true about Erlotinib except: (AI 2011)
(a) Used in non small cell carcinoma of lung
(b) It is a small molecule tyrosine kinase inhibitor acting
as EGFR antagonist
(c) Food decreases absorption
(d) It causes skin rashes and diarrhea
86. Thalidomide is used in all of the following except:
(AIIMS May 2010) (AIIMS May 2009)
(a) HIV associated peripheral neuropathy
(b) HIV associated aphthous (mouth) ulcers
(c) Behcet syndrome
(d) Erythema nodosum leprosum
87. All of the following are true about thalidomide except:
(a) Used in pregnancy as anti-emetic but withdrawn
due to teratogenicity (AI 2010)
(b) Can be used in multiple myeloma as primary treatment
as well as in refractory disease
(c) Causes euphoria and diarrhea
(d) Can be used in erythema nodosum leprosum
88. Which of the following drug acts by inhibiting tyrosine
kinase activated by EGF receptor as well as HER2?
(a) Imatinib (AI 2010)
(b) Geftinib
(c) Erlotinib
(d) Lapatinib
89. Tyrosine kinase inhibitors are first line treatment in:
(a) Gastrointestinal stromal tumors (AI 2010)
(b) Receptor mediated neuroendocrine tumors
(c) Breast cancer
(d) Renal cell carcinoma
90. Cetuximab (an EGFR antagonist) can be used in:
(a) Palliation in head and neck cancer (AIIMS May 2009
(b) Anal canal carcinoma
(c) Gastric carcinoma
(d) Lung carcinoma
91. Amifostine is protective to all except: (AI 2009)
(a) Salivary glands
(b) Skin
(c) CNS
(d) GIT
92. Imatinib is used in the treatment of? (AIIMS May 2008)
(a) Chronic myelomonocytic leukemia
(b) Myelodysplastic syndrome
(c) Acute lymphoid leukemia
(d) Gastro intestinal stromal tumors
93. Rituximab is used in all except: (AIIMS May 2008)
(a) Non Hodgkin lymphoma
(b) Paroxysomal nocturnal hemoglobinurea
(c) Rheumatoid arthritis
(d) Systemic lupus erythematosis
94. A 56 year old female presented with breast carcinoma
and she was prescribed herceptin (trastuzumab). Which
of the following statements regarding this drug is
true? (AIIMS Nov 2008)
(a) It is an antibody produced entirely from mouse containing
no human component.
(b) It is a monoclonal antibody produced by injecting
her-2 antigen.
(c) It is a polyclonal antibody
(d) It is a monoclonal antibody containing only human
component
95. Thalidomide, used for multiple myeloma, is:
(a) Associated with diarrhea (DPG 2009)
(b) Characterized by enantiomeric interconversions
(c) Metabolized extensively by hepatic CYP system
(d) Safe for use in pregnant females
96. Which of the following anticancer drugs acts by
hypomethylation? (AI 2007)
(a) Gemcitabine
(b) 5-FU
(c) Decitabine
(d) Homoharringotonine
97. All the following are hormonal agents used against
breast cancer EXCEPT: (AI 2004)
(a) Letrozole
(b) Exemestane
(c) Taxol
(d) Tamoxifen
98. Gemcitabine is effective in: (AI 2002)
(a) Head and neck cancers
(b) Pancreatic cancer
(c) Small-cell lung cancer
(d) Soft tissue sarcoma
99. Arsenic is useful in the treatment of: (AIIMS May, 2007)
(a) Acute promyelocytic leukemia
(b) Myelodysplastic syndrome
(c) Transient myeloproliferative disorder
(d) All of the above
100. Mechanism of action of imatinib mesylate is:
(AIIMS May, 2007)
(a) Increase in metabolism of P glycoprotein
(b) Blocking the action of P glycoprotein
(c) Blocks the action of chimeric fusion protein of bcrabl
(d) Non-competitive inhibition of ATP binding site
101. The drug imatinib acts by the inhibition of:
(a) Tyrosine kinase (AIIMS May, 2006)
(b) Glutathione reductase
(c) Thymidylate synthetase
(d) Protein kinase
102. The new drug pemetrexed useful in breast cancer
belongs to which of the following category of the drugs?
(a) Antitumor agent (AIIMS Nov, 2005)
(b) Alkylating agent
(c) Hormonal agent
(d) Antimetabolite
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