Review of Pharmacology - 9E (2015)

Endocrinology
280
Review of Pharmacology
(c) Ovarian cancer
(d) Ischemic stroke
195. A 23-year old woman desires a combined oral
contraceptive for pregnancy protection. A factor that
would lead a health professional to recommend an
alternative form of contraception is that the woman:
(a) Has an evidence of hirsutism
(b) Has a history of gastroesophageal reflux disease and
is currently taking omeprazole
(c) Has a history of pelvic inflammatory disease
(d) Has a history of migraine headache that is well
controlled by sumatriptan
196. A drug ‘X’ primarily reduces the static component of
urinary obstruction in benign hypertrophy of prostate
and takes more than 3 months to exert its beneficial
effect. Which of the following is ‘X’?
(a) Tamsulosin
(b) Terazosin
(c) Finasteride
(d) Amphetamine
197. Dr. Shweta decided to add a progestin for 10-12
days each month to estrogen replacement therapy in
menopausal women in the gynaecology OPD. Addition
of progestin is recommended because the progestin:
(a) Blocks the increased risk of myocardial infarction
due to estrogen
(b) Blocks the increased risk of endometrial carcinoma
due to estrogen
(c) Reverses vulval atrophy occurring in post menopausal
women
(d) Enhances the metabolic benefits of estrogen
treatment
198. A young female Shagun comes to you in the gynaecology
OPD and gives the history that she had intercourse with
her boyfriend 5 hours back. Select the drug that can act
as a single dose postcoital contraceptive for her:
(a) Clomiphene citrate
(b) Mifepristone
(c) Danazol
(d) Medroxyprogesterone acetate
199. A patient Parul gives you the history that she has missed
a single dose of her combined oral contraceptive pill.
Which of the following will you advise her?
(a) Continue with the course without regard to the
missed dose
(b) Take 2 pills the next day and continue with the
course
(c) Take 2 pills everyday for the remaining part of the
course
(d) Discontinue the course and use alternative method
of contraception
200. Oral contraceptive pills can cause all except: (DPG 2010)
(a) Mastalgia
(b) Dysmenorrhea
(c) Chloasma
(d) Breakthrough bleeding
201. Side effects of oral contraceptives are all EXCEPT:
(a) Irregular bleeding (DPG 2007)
(b) Headache
(c) Thrombosis
(d) Increased risk of ovarian cancer
202. All of the following are natural estrogens EXCEPT:
(a) Estradiol (RJ 2008, DPG 2006)
(b) Ethinylestradiol
(c) Estriol
(d) Estrone
203. Mechanism of action of tamoxifen is: (DPG 2000)
(a) Has androgenic receptor blocking action
(b) Inhibits enzyme 5 α-reductase
(c) Has partial agonist and antagonist action on estrogen
receptors
(d) Inhibition of FSH and LH release from the pituitary
204. The progestogenic emergency contraceptive pills act
by: (MPPG 2007)
(a) Altered cervical secretion
(b) Inhibition of ovulation
(c) Anti-implantation effect
(d) Inhibition of LH secretion
205. Which one of the following agents inhibits sper matogenesis?
(MPPG 2002, DPG 2001)
(a) Gelusil
(b) Gemcadiol
(c) Gestodene
(d) Gossypol
206. Which one of the following has both estrogenic and
anti-estrogenic property: (MPPG 2002)
(a) Chlorpromazine
(b) Clofibrate
(c) Clomiphene
(d) Clonidine
207. Tamoxifen is useful in: (MPPG 2001)
(a) Carcinoma prostate
(b) Carcinoma ovary
(c) Estrogen receptor positive breast carcinoma
(d) Seminoma
208. Thromboembolism is due to which component of oral
contraceptive pills: (MPPG 2001)
(a) Progesterone
(b) Estrogen
(c) Iron
(d) FSH
209. An example of antiprogesterone is: (TN 2002)
(a) Gossypol
(b) Atosiban
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