Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Chemotherapy A: General Considerations and Non-specific...<br />

540<br />

<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

16. The persistent suppression <strong>of</strong> bacterial growth that may<br />

occur after limited exposure to some antimicrobial drug<br />

is called:<br />

(a) Time dependent killing<br />

(b) Post antibiotic effect<br />

(c) Concentration dependent killing<br />

(d) Sequential blockade<br />

17. Which <strong>of</strong> the following is not an established antimicrobial<br />

drug synergism at clinical level?<br />

(a) Amphotericin B and flucytosine in cryptococcal menin<br />

gitis<br />

(b) Carbenicillin and gentamicin in pseudomonal infections<br />

(c) Penicillin and tetracycline in bacterial meningitis<br />

(d) Trimethoprim and sulfamethoxazole in coliform<br />

infec tions<br />

18. Which <strong>of</strong> the following drugs is NOT excreted in bile:<br />

(a) Erythromycin<br />

(b) Ampicillin<br />

(c) Rifampicin<br />

(d) Gentamicin<br />

19. Multiple drug resistance is transferred through:<br />

(a) Transduction (DPG 2008)<br />

(b) Transformation<br />

(c) Conjugation<br />

(d) Mutation<br />

20. Most common mechanism for transfer <strong>of</strong> resis tance in<br />

Staphylococcus aureus is: (DPG 2009, DPG 2007)<br />

(a) Conjugation<br />

(b) Transduction<br />

(c) Transformation<br />

(d) Mutation<br />

21. Elaboration <strong>of</strong> inactivating enzymes are the important<br />

mechanism <strong>of</strong> drug resistance among all <strong>of</strong> these<br />

antibiotics EXCEPT: (DPG 2000, DPG 2007)<br />

(a) Quinolones<br />

(b) Penicillin<br />

(c) Chloramphenicol<br />

(d) Aminoglycosides<br />

22. Pneumococcal resistance to penicillin G is mainly<br />

acquired by: (DPG 2006)<br />

(a) Conjugation<br />

(b) Transduction<br />

(c) Transformation<br />

(d) All <strong>of</strong> the above<br />

23. A bactericidal drug would be preferred over a<br />

bacteriostatic drug in a patient with: (DPG 2005)<br />

(a) Neutropenia<br />

(b) Cirrhosis<br />

(c) Pneumonia<br />

(d) Heart disease<br />

24. Which <strong>of</strong> the following antibiotic acts by inhibiting cell<br />

wall synthesis? (DPG 2002)<br />

(a) Chloramphenicol<br />

(b) Gentamicin<br />

(c) Erythromycin<br />

(d) Penicillin<br />

25. Which <strong>of</strong> the following drugs acts by inhibiting cell<br />

wall synthesis? (DPG 1997)<br />

(a) Erythromycin<br />

(b) Cephalosporins<br />

(c) Chloramphenicol<br />

(d) Sulfonamides<br />

26. In staphylococci, plasmids encoding beta-lactamase are<br />

transmitted by: (MPPG 2007)<br />

(a) Conjugation<br />

(b) Transduction<br />

(c) Transposon<br />

(d) Transformation<br />

27. Which <strong>of</strong> the following drug is bactericidal? (UP 2006)<br />

(a) Sulfonamides<br />

(b) Erythromycin<br />

(c) Chloramphenicol<br />

(d) Cotrimoxazole<br />

28. Superinfection is common in: (UP 2006)<br />

(a) Narrow spectrum antibiotics<br />

(b) Immunocompromised host<br />

(c) Low spectrum antibiotics<br />

(d) Nutritional deficiency<br />

29. Which <strong>of</strong> the following is a broad spectrum antibiotic?<br />

(a) Erythromycin (RJ 2005)<br />

(b) Streptomycin<br />

(c) Tetracycline<br />

(d) All<br />

30. Which <strong>of</strong> the following antibiotic does not act by<br />

inhibiting protein synthesis? (MH 2005)<br />

(a) Vancomycin<br />

(b) Tetracycline<br />

(c) Streptomycin<br />

(d) Azithromycin<br />

cell wall synthesis inhibitors<br />

31. Which <strong>of</strong> the following antimicrobial is effective<br />

against an organism producing extended spectrum beta<br />

lactamase? (AIIMS Nov 2012)<br />

(a) Amoxicillin–Clavulinic acid<br />

(b) Cefepime<br />

(c) Piperacillin-Tazobactam<br />

(d) Ceftriaxone<br />

32. Which <strong>of</strong> the following statement about Penicillin G is<br />

true? (AIIMS Nov 2012)<br />

(a) It is commonly administered orally<br />

(b) It has a broad spectrum <strong>of</strong> antibacterial activity<br />

(c) It can be used for the treatment rate bite fever<br />

(d) Concomitant probenecid decreases its duration <strong>of</strong><br />

action<br />

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