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NOTES _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ _________________________________________________________________________________________________________________ https://kat.cr/user/Blink99/
Image Based Questions https://kat.cr/user/Blink99/
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Review of Pharmacology Ninth Editio
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Dedicated to My parents, wife Prave
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Preface to the Ninth Edition We wan
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Acknowledgments When emotions are p
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References • Harrison’s Princip
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Contents 1. History of Pharmacology
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CHAPTER 1 History of pharmacology S
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CHAPTER 2 General Pharmacology Phar
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General Pharmacology Note: It is si
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General Pharmacology Drug metaboliz
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General Pharmacology Order of kinet
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General Pharmacology Therapeutic Dr
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General Pharmacology Fig. 2.4: G-pr
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General Pharmacology sigmoid shaped
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General Pharmacology Phase 1: Here,
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General Pharmacology 5. Essential m
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General Pharmacology (b) Bioavailab
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General Pharmacology (c) Are highly
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General Pharmacology (c) Strong aci
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General Pharmacology (a) 50 mg/hour
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General Pharmacology 140. Phamacoge
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General Pharmacology (c) Piroxicam
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206. Which of the following drugs s
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General Pharmacology 29. In which t
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General Pharmacology Explanations 1
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General Pharmacology • Other fact
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General Pharmacology -- Suppose, 10
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General Pharmacology 77. Ans. (a) W
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= 40 L × 4 mg/L = 160 mg Clearance
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General Pharmacology 126. Ans. (c)
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General Pharmacology 154. Ans. (d)
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General Pharmacology Intolerance is
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General Pharmacology 6. Ans. (b) b
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CHAPTER 3 Autonomic Nervous System
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Autonomic Nervous System Functions
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Autonomic Nervous System • Carbac
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Autonomic Nervous System used for g
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Autonomic Nervous System -- Central
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Autonomic Nervous System • Theref
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Autonomic Nervous System • Eye: S
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Autonomic Nervous System • Dopami
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Autonomic Nervous System • Phenox
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Autonomic Nervous System Lipid Inso
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Autonomic Nervous System Drug of Ch
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Multiple Choice Questions Autonomic
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Autonomic Nervous System (c) Organo
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(c) Physostigmime (d) Hyoscine hydr
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Autonomic Nervous System (c) Tropic
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132. A drug that blocks the uptake
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165. Clonidine is used for: (Kolkat
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as an effective substitute which do
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Autonomic Nervous System 13. Which
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Autonomic Nervous System (c) Increa
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Autonomic Nervous System 9. Ans. (a
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Autonomic Nervous System 39. Ans. (
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Autonomic Nervous System - Temazepa
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Autonomic Nervous System 103. Ans.
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Autonomic Nervous System have no ef
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Autonomic Nervous System 166. Ans.
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Autonomic Nervous System 194. Ans.
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Autonomic Nervous System 23. Ans. (
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CHAPTER 4 Autacoids These are the s
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Autacoids All second generation ant
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Autacoids v v v v v Calcium channel
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Autacoids nary bypass. It can also
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Autacoids to presence of sulfur con
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Autacoids Rheumatoid Arthritis Rheu
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Autacoids It is a monoclonal antibo
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Autacoids Drug of choice Condition
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15. Anti-vertigo drug which modulat
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49. Sumatriptan is: (DPG 1999, TN 2
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81. All of the following effects ar
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114. Which prostaglandin helps in c
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Autacoids 148. Which of the followi
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Autacoids 30. A 15 year old boy was
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Autacoids 16. Ans. (b) Dangerous ve
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Autacoids 56. Ans. (c) Cyclooxygena
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Autacoids 85. Ans. (b) Aspirin supp
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Autacoids 125. Ans. (b) Indomethaci
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Autacoids 13. Ans. (a) Naproxen (Re
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CHAPTER 5 Cardiovascular System CON
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Cardiovascular System In atrial fib
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Cardiovascular System Treatment of
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Cardiovascular System should be use
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Cardiovascular System tive α 1 blo
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Cardiovascular System nifedipine an
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Cardiovascular System Treatment of
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Cardiovascular System ANGINA PECTOR
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Cardiovascular System BETA BLOCKERS
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Cardiovascular System The action po
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Cardiovascular System depolarized c
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Cardiovascular System • Digoxin i
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Cardiovascular System Contd... •
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Cardiovascular System DRUG OF CHOIC
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15. Digoxin toxicity is aggravated
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(c) Treat digoxin toxicity (d) Rapi
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(c) Decreases sodium and increases
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Cardiovascular System 113. All of t
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146. Which of the following drugs i
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Cardiovascular System 180. Characte
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213. In a patient with hypertriglyc
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247. ACE inhibitors cause: (PGI Dec
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Cardiovascular System 16. Dialysis
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Cardiovascular System 53. Which of
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• Nesiritide is a recombinant BNP
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Cardiovascular System 43. Ans. (d)
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Cardiovascular System 81. Ans. (a)
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Cardiovascular System -- Hypertensi
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Cardiovascular System Cyanide has v
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Cardiovascular System 178. Ans. (a)
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Cardiovascular System 217. Ans. (a)
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Cardiovascular System 237. Ans. (a)
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Cardiovascular System 13. Ans (b) P
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CHAPTER 6 Kidney Diuretics Diuretic
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Kidney Uses Main use of loop diuret
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Kidney • Amiloride is more potent
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Kidney Amiloride It is the agent of
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Kidney Multiple Choice Questions di
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30. Which of the following statemen
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66. Advantage of desmopressin over
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Kidney Explanations 1. Ans. (b) Hyp
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16. Ans. (b) Bumetanide (Ref: KDT 6
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Kidney 55. Ans (d) V 4 : Central Ne
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CHAPTER 7 Endocrinology Hormones ar
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Endocrinology Prolactin It causes g
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Endocrinology • In the liver and
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Endocrinology I 131 can be used for
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Endocrinology Drug interactions •
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Endocrinology Lactic acidosis (more
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Endocrinology 3. amylin analogs Pra
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Endocrinology Important Points Maxi
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Endocrinology • Steroids with sel
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Endocrinology • Vitamin D 2 is er
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Endocrinology Denosumab Osteoclasts
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Endocrinology • SERMs are targete
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Endocrinology Contd... • Uliprist
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Endocrinology only pills. Chances o
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Endocrinology Pharmacokinetics Test
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Endocrinology Ergot Derivatives Erg
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Endocrinology Contd... • Hyperpro
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completion of therapy, the patient
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(c) Glucose (d) Starch 47. True abo
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(c) Na + exit/K + entry (d) K + ent
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Endocrinology 113. Which of the fol
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147. Bisphosphonates act by: (AI 20
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180. Women receiving estrogen thera
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(c) Clomiphene (d) Mifepristone (RU
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246. Mechanism of Calcitriol is: (R
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Endocrinology 32. Drug used to cont
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(b) Glimepiride (c) Repaglinide (d)
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Endocrinology Explanations 1. Ans.
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Endocrinology 24. Ans. (c) Propylth
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Endocrinology • When this drug is
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Endocrinology Hypoglycemia is cause
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Endocrinology Drugs causing Addison
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Endocrinology Raloxifene is a selec
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Endocrinology • Enzyme inducers l
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Endocrinology 197. Ans. (b) Blocks
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Endocrinology A spider angioma (als
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Endocrinology 4. Ans (c) Glaucoma (
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Endocrinology 70. Ans. (c) Mifepris
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NOTES _____________________________
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CHAPTER 8 Central Nervous System Se
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Central Nervous System It is admini
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Central Nervous System • Abnormal
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Central Nervous System useful in AD
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Central Nervous System Wilson’s D
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Central Nervous System Important Dr
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Central Nervous System • Lamotrig
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Central Nervous System play a role
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Central Nervous System According to
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Central Nervous System bulimia, pre
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Central Nervous System Anti Manic D
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Central Nervous System dependence,
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Central Nervous System increase hea
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Central Nervous System Actions •
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Central Nervous System Contd... •
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(c) Alkalization of the urine will
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Central Nervous System (c) Ketamine
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79. Drug of choice for myoclonic ep
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(c) Phenytoin (d) Valproic acid 112
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146. Which of the following antipsy
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(c) Regular measurements of blood c
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210. A patient Rajnish having depre
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242. Drug useful in malignant hyper
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279. Preferred drug for alcohol wit
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314. Morphine can administered by a
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(c) Analgesia (d) Mydriasis 348. Di
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17. Antiparkinson drug known to cau
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53. Which drug is the most useful i
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Central Nervous System 15. Ans. (c)
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Central Nervous System 39. Ans. (b)
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67. Ans. (a) Phenytoin (Ref: Katzun
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97. Ans. (a) Hepatitis (Ref: KDT 6/
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Central Nervous System 145. Ans (c)
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Central Nervous System 159. Ans. (d
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Central Nervous System 187. Ans. (b
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Central Nervous System 212. Ans. (a
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Central Nervous System 258. Ans. (a
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Central Nervous System 286. Ans. (b
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Central Nervous System 303. Ans. (c
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Central Nervous System 326. Ans. (c
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Central Nervous System 366. Ans. (b
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Central Nervous System 60. Ans. (a)
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CHAPTER 9 Anaesthesia Local Anaesth
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Anaesthesia trigeminal nerve, cervi
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Anaesthesia Centrally Acting Muscle
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Anaesthesia • These drugs release
- Page 417 and 418:
Anaesthesia Anaesthetic MAC (% atm)
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Anaesthesia Methemoglobinemia and l
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Anaesthesia Chloroform • It is a
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Anaesthesia Contd... • It does no
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Anaesthesia Anaesthetic agents of c
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Anaesthesia Multiple Choice Questio
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33. Post dural (Spinal) puncture he
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(b) Dantrolene (c) Succinylcholine
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103. Which of the following drugs a
- Page 435 and 436:
Anaesthesia 138. Thiopental sodium
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Anaesthesia Explanations 1. Ans (c)
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Anaesthesia 20. Ans. (d) Seizures a
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Anaesthesia 49. Ans. (b) Meprobamat
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Anaesthesia • The patient underwe
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Anaesthesia 91. Ans. (b) Sevofluran
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Anaesthesia • In pheochromocytoma
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CHAPTER 10 Hematology HAEMATINICS T
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Hematology • Deficiency of folic
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Hematology • Main drugs acting as
- Page 455 and 456:
Hematology 1. Oral Anticoagulants
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Hematology • Bioavailability of u
- Page 459 and 460:
Hematology • Rodenticides contain
- Page 461 and 462:
Hematology Condition • Anemia Dru
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(c) Erythropoietin (d) Filgrastim (
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Hematology 46. Tirofiban is a: (RJ
- Page 467 and 468:
80. The anticoagulant of choice in
- Page 469 and 470:
6. Mechanism of action of clopidogr
- Page 471 and 472:
Hematology Explanations 1. Ans. (c)
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Hematology 17. Ans. (d) Oprelvekin
- Page 475 and 476:
Hematology 51. Ans. (a) Dabigatran:
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Hematology 71. Ans. (c) Warfarin (R
- Page 479 and 480:
Hematology 106. Ans. (c) Streptokin
- Page 481 and 482:
CHAPTER 11 Respiratory System Cough
- Page 483 and 484:
Respiratory System fast acting also
- Page 485 and 486:
Respiratory System LT receptor anta
- Page 487 and 488:
Respiratory System Condition • Br
- Page 489 and 490:
17. The most prominent and dose rel
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Respiratory System 52. In theophyll
- Page 493 and 494:
Respiratory System Explanations 1.
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Respiratory System • Inhalational
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CHAPTER 12 Gastrointestinal Tract P
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Gastrointestinal Tract Contd... --
- Page 501 and 502:
Gastrointestinal Tract Anti Emetic
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Gastrointestinal Tract Domperidone
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Gastrointestinal Tract Oral Rehydra
- Page 507 and 508:
Gastrointestinal Tract Condition
- Page 509 and 510:
(c) Misoprostol (d) Omeprazole 15.
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49. The most effective antiemetic f
- Page 513 and 514:
Gastrointestinal Tract recent Quest
- Page 515 and 516:
Gastrointestinal Tract Explanations
- Page 517 and 518:
Gastrointestinal Tract 30. Ans. (b)
- Page 519 and 520:
Gastrointestinal Tract 1. EarlyPhas
- Page 521 and 522:
Gastrointestinal Tract 17. Ans. (c)
- Page 523 and 524:
CHAPTER 13 Chemotherapy A: General
- Page 525 and 526:
Chemotherapy A: General Considerati
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contd... Drugs Binds to Mechanism o
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Chemotherapy A: General Considerati
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Chemotherapy A: General Considerati
- Page 533 and 534:
Contd... Chemotherapy A: General Co
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Chemotherapy A: General Considerati
- Page 537 and 538:
Clinical Uses Chemotherapy A: Gener
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Chemotherapy A: General Considerati
- Page 541 and 542:
Chemotherapy A: General Considerati
- Page 543 and 544:
Chemotherapy A: General Considerati
- Page 545 and 546:
Important Points About Antimicrobia
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Chemotherapy A: General Considerati
- Page 549 and 550:
Chemotherapy A: General Considerati
- Page 551 and 552:
Chemotherapy A: General Considerati
- Page 553 and 554:
Chemotherapy A: General Considerati
- Page 555 and 556:
Chemotherapy A: General Considerati
- Page 557 and 558:
Chemotherapy A: General Considerati
- Page 559 and 560:
Chemotherapy A: General Considerati
- Page 561 and 562:
Chemotherapy A: General Considerati
- Page 563 and 564:
Chemotherapy A: General Considerati
- Page 565 and 566:
Chemotherapy A: General Considerati
- Page 567 and 568:
Chemotherapy A: General Considerati
- Page 569 and 570:
Chemotherapy A: General Considerati
- Page 571 and 572:
Chemotherapy A: General Considerati
- Page 573 and 574:
Chemotherapy A: General Considerati
- Page 575 and 576:
Chemotherapy A: General Considerati
- Page 577 and 578:
Chemotherapy A: General Considerati
- Page 579 and 580:
128. Ans. (b) Trovafloxacin (Goodma
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Chemotherapy A: General Considerati
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Chemotherapy A: General Considerati
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Chemotherapy A: General Considerati
- Page 587 and 588:
Chemotherapy A: General Considerati
- Page 589 and 590:
CHAPTER 14 Chemotherapy B: Antimicr
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Chemotherapy B: Antimicrobials for
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Clofazimine It is a dye with lepros
- Page 595 and 596:
Chemotherapy B: Antimicrobials for
- Page 597 and 598:
Foscarnet It is not an antimetaboli
- Page 599 and 600:
Human Immunodeficiency Virus (HIV)
- Page 601 and 602:
Chemotherapy B: Antimicrobials for
- Page 603 and 604:
Chemotherapy B: Antimicrobials for
- Page 605 and 606:
Chemotherapy B: Antimicrobials for
- Page 607 and 608:
Chemotherapy B: Antimicrobials for
- Page 609 and 610:
Chemotherapy B: Antimicrobials for
- Page 611 and 612:
Chemotherapy B: Antimicrobials for
- Page 613 and 614:
Chemotherapy B: Antimicrobials for
- Page 615 and 616:
16. Bactericidal drugs in ATT are:
- Page 617 and 618:
50. Ethambutol should be used very
- Page 619 and 620:
Chemotherapy B: Antimicrobials for
- Page 621 and 622:
120. Regarding ritonavir use in AID
- Page 623 and 624:
ACTs). All of the following combina
- Page 625 and 626:
Chemotherapy B: Antimicrobials for
- Page 627 and 628:
ecent Questions asked by National B
- Page 629 and 630:
Chemotherapy B: Antimicrobials for
- Page 631 and 632:
Explanations Chemotherapy B: Antimi
- Page 633 and 634:
25. Ans. (b) Ethionamide (Ref: KDT
- Page 635 and 636:
Chemotherapy B: Antimicrobials for
- Page 637 and 638:
Chemotherapy B: Antimicrobials for
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Chemotherapy B: Antimicrobials for
- Page 641 and 642:
Chemotherapy B: Antimicrobials for
- Page 643 and 644:
Chemotherapy B: Antimicrobials for
- Page 645 and 646:
Chemotherapy B: Antimicrobials for
- Page 647 and 648:
CHAPTER 15 Chemotherapy C: Antineop
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Chemotherapy C: Antineoplastic Drug
- Page 651 and 652:
Chemotherapy C: Antineoplastic Drug
- Page 653 and 654:
4-5 years). Another distinguishing
- Page 655 and 656:
Chemotherapy C: Antineoplastic Drug
- Page 657 and 658:
GnRH Antagonists Cetrorelix, ganire
- Page 659 and 660:
This drug was used in 1960s as a se
- Page 661 and 662:
Chemotherapy C: Antineoplastic Drug
- Page 663 and 664:
Multiple Choice Questions Chemother
- Page 665 and 666:
37. Which of the following statemen
- Page 667 and 668:
Chemotherapy C: Antineoplastic Drug
- Page 669 and 670:
Chemotherapy C: Antineoplastic Drug
- Page 671 and 672:
Chemotherapy C: Antineoplastic Drug
- Page 673 and 674:
Chemotherapy C: Antineoplastic Drug
- Page 675 and 676:
Chemotherapy C: Antineoplastic Drug
- Page 677 and 678:
Chemotherapy C: Antineoplastic Drug
- Page 679 and 680:
Chemotherapy C: Antineoplastic Drug
- Page 681 and 682:
Chemotherapy C: Antineoplastic Drug
- Page 683 and 684:
Chemotherapy C: Antineoplastic Drug
- Page 685 and 686:
CHAPTER 16 Immunomodulators IMMUNOS
- Page 687 and 688:
Immunomodulators 9. Antibodies Poly
- Page 689 and 690:
Immunomodulators Examples of each t
- Page 691 and 692:
Immunomodulators Clinical Diagnosis
- Page 693 and 694:
(b) Podophylline (c) Interferon (d)
- Page 695 and 696:
(c) Cytarabine (d) Cycloserine 51.
- Page 697 and 698:
Immunomodulators Explanations 1. An
- Page 699 and 700:
Immunomodulators 14. Ans. (a) Syste
- Page 701 and 702:
Immunomodulators 33. Ans. (a) Gluco
- Page 703 and 704:
CHAPTER 17 Other Topics and Adverse
- Page 705 and 706:
Other Topics and Adverse Effects Co
- Page 707 and 708:
Other Topics and Adverse Effects Co
- Page 709 and 710:
Other Topics and Adverse Effects Co
- Page 711 and 712:
17. A 2 years old child without fev
- Page 713 and 714:
54. Isotretinoin is: (PGI June, 200
- Page 715 and 716:
Other Topics and Adverse Effects (c
- Page 717 and 718:
Other Topics and Adverse Effects
- Page 719 and 720:
Other Topics and Adverse Effects
- Page 721 and 722: Other Topics and Adverse Effects 39
- Page 723 and 724: Other Topics and Adverse Effects 55
- Page 725 and 726: Other Topics and Adverse Effects Dr
- Page 727 and 728: CHAPTER 18 Drugs of Choice Drug of
- Page 729 and 730: Drugs of Choice Contd... Hypertensi
- Page 731 and 732: Contd... VRSA LINEZOLID/STREPTOGRAM
- Page 733 and 734: CHAPTER 19 New Drugs 1. Abatacept:
- Page 735 and 736: New Drugs 52. Canakinumab: A human
- Page 737 and 738: New Drugs 100. Ecallantide: A plasm
- Page 739 and 740: New Drugs 153. Laronidase: Recombin
- Page 741 and 742: New Drugs 204. Peginesatide: A pept
- Page 743 and 744: New Drugs been approved for the tre
- Page 745 and 746: New Drugs and B lymphocytes after e
- Page 747 and 748: New Drugs prevents nausea and vomit
- Page 749 and 750: CHAPTER 20 Recent Topics TRICYCLIC
- Page 751 and 752: Recent Topics 2. Drugs 5-HT 2 recep
- Page 753 and 754: Recent Topics Arginine NOS NO + Cit
- Page 755 and 756: Recent Topics Contd... Drug Tetracy
- Page 757 and 758: Recent Topics -- If the patient has
- Page 759 and 760: CHAPTER 21 Latest Papers AIIMS Nove
- Page 761 and 762: Latest Papers explanations 1. Ans.
- Page 763 and 764: • Clindamycin and erythromycin ar
- Page 765 and 766: Latest Papers AIIMS May 2014 1. Whi
- Page 767 and 768: Latest Papers explanations 1. Ans.
- Page 769 and 770: 13. Ans. a. Hypokalemia (Ref: Harri
- Page 771: NOTES _____________________________
- Page 775 and 776: Image Based Questions 1. The result
- Page 777 and 778: 5. A new antiarrhythmic drug is fou
- Page 779 and 780: 10. Amarnath, a 58 year old busines
- Page 781 and 782: 14. A 72-year-old male, Hemraj was
- Page 783 and 784: (rapid vs slow induction of anesthe
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