Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Chemotherapy C: Antineoplastic Drugs<br />

15. Drug not acting on tubulin is:<br />

(a) Bleomycin<br />

(b) Colchicine<br />

(c) Paclitaxel<br />

(d) Vincristine<br />

16. All drugs are used in treatment <strong>of</strong> breast carcinoma<br />

except:<br />

(a) Tamoxifen<br />

(b) Flutamide<br />

(c) Cyclophosphamide<br />

(d) Letrozole<br />

17. Which antineoplastic drug has a very high cardiac<br />

toxicity?<br />

(a) Bleomycin<br />

(b) Actinomycin-D<br />

(c) Doxorubicin<br />

(d) Mitomycin-C<br />

18. Regarding trastuzumab, all <strong>of</strong> the following are true<br />

except:<br />

(a) Shows better response in combination with paclitaxel<br />

(b) Used in non-metastatic breast cancer<br />

(c) Causes upregulation <strong>of</strong> HER2/neu<br />

(d) Do not cause bone marrow toxicity<br />

19. Methotrexate resistance is due to:<br />

(a) Increased concentrations <strong>of</strong> intracellular DHFR<br />

through gene amplification<br />

(b) Failure <strong>of</strong> efflux pumps<br />

(c) Bacterial modification<br />

(d) Increased synthesis <strong>of</strong> poly glutamates<br />

20. Which <strong>of</strong> the following is not an antimetabolite?<br />

(a) Methotrexate<br />

(b) 5 Fluorouracil<br />

(c) Gemcitabine<br />

(d) Vincristine<br />

21. Cyclophosphamide is:<br />

(a) Alkylating agent<br />

(b) Antitumor antibiotic<br />

(c) Monoclonal antibody<br />

(d) Antimetabolites<br />

22. Most characteristic side effect <strong>of</strong> adriamycin is:<br />

(a) Nephrotoxicity<br />

(b) Neurotoxicity<br />

(c) Cardiotoxicity<br />

(d) Hemorrhagic cystitis<br />

23. Mechanism <strong>of</strong> action <strong>of</strong> 5-FU is:<br />

(a) Antimetabolite<br />

(b) Direct DNA chelating agent<br />

(c) Anti-Mitotic<br />

(d) Topoisomerase inhibitor<br />

24. Anticancer drug that causes lung fibrosis is:<br />

(a) Bleomycin<br />

(b) Cisplatin<br />

(c) Fulvestrant<br />

(d) Tamoxifen<br />

25. Treatment <strong>of</strong> chronic phase <strong>of</strong> CML is:<br />

(a) Imatinib<br />

(b) Hydroxyurea<br />

(c) Interferon<br />

(d) Cytarabine<br />

26. Which <strong>of</strong> the following is not an alkylating agent?<br />

(a) Chlorambucil<br />

(b) Ifosfamide<br />

(c) Nitrosourea<br />

(d) Cladribine<br />

27. Ifosfamide belong to which class?<br />

(a) Alkylating agent<br />

(b) Antimetabolite<br />

(c) Taxanes<br />

(d) Antibiotics<br />

28. Which <strong>of</strong> the following is not an alkylating agent?<br />

(a) 5-FU<br />

(b) Busulfan<br />

(c) Cyclophosphamide<br />

(d) Melphalan<br />

29. Pulmonary fibrosis is caused by:<br />

(a) Methotrexate<br />

(b) Cyclophosphamide<br />

(c) Mercaptopurine<br />

(d) Busulfan<br />

30. Thalidomide acts through:<br />

(a) Inhibiting angiogenesis<br />

(b) Inhibiting thymidylate synthase<br />

(c) Inhibition <strong>of</strong> Topo-isomerase I<br />

(d) Inhibition <strong>of</strong> Topo-isomerase II<br />

31. The chemotherapeutic agent <strong>of</strong> choice for concurrent<br />

chemoradiation in carcinoma cervix is:<br />

(a) Paclitaxel<br />

(b) Hydroxyurea<br />

(c) 5 FU (fluorouracil)<br />

(d) Cisplatin<br />

tahir99 - UnitedVRG<br />

32. Medical adrenalectomy is seen with:<br />

(a) Vincristine<br />

(b) Vinblastine<br />

(c) Mitotane<br />

(d) Methotrexate<br />

33. Which <strong>of</strong> the following is a highly emetogenic chemotherapy<br />

drug:<br />

(a) 5-Fluorouracil<br />

(b) Paclitaxel<br />

(c) Vincristine<br />

(d) Cisplatin<br />

Chemotherapy General C: <strong>Pharmacology</strong><br />

Antineoplastic Drugs<br />

659<br />

https://kat.cr/user/Blink99/

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