Review of Pharmacology - 9E (2015)

Review of Pharmacology
Cardiovascular System
67. Calcium channel blocking agents of use in the treatment
of hypertension include: (DPG 2009)
(a) Prazosin
(b) Lidoflazine
(c) Captopril
(d) Nifedipine
68. Which of the following is NOT a frontline
antihypertensive agent? (DPG 2009)
(a) Enalapril
(b) Hydrochlorthiazide
(c) Amlodipine
(d) Atenolol
69. Which of the following drugs should NOT be used in
setting of severe hypertension in elderly on empirical
basis? (DPG 2009)
(a) Enalapril
(b) Amlodipine
(c) Chlorthiazide
(d) Prazosin
70. All of the following statements about clonidine are true
EXCEPT: (AI 2007)
(a) It is an α-adrenergic agonist
(b) It can cause dry mouth as an adverse effect
(c) Prazosin completely antagonizes its action
(d) It inhibits sympathetic outflow.
71. All of the following are useful in the intravenous
therapy for hypertensive emergencies except: (AI 2003)
(a) Fenoldopam
(b) Urapidil
(c) Enalaprilat
(d) Nifedipine
72. The mechanism of action of sodium nitroprusside is:
(a) Increased cAMP (AI 2002)
(b) Stimulation of guanylate cyclase
(c) Calcium channel blockage
(d) K + channel opener
73. A 50 year old male presents with malignant hypertension.
The drug of choice is: (AI 2000)
(a) Sodium nitroprusside
(b) Sublingual nifedipine
(c) Furosemide
(d) Enalapril
74. Maximum incidence of impotence is seen with the
following anti-hypertensive agent: (AIIMS May, 2007)
(a) CCBs
(b) Beta blockers
(c) ARBs
(d) ACE inhibitors
75. Which drug should not be given in pregnancy?
(a) Labetalol (AIIMS May, 2007)
(b) ACE inhibitors (APPG 2007)
(c) Hydralazine (AIIMS Nov, 2004)
(d) Methyl dopa (DPG 2008, Bihar 2006)
76. Which of the following statements about hydralazine is
not true? (AIIMS Nov, 2004)
(a) It causes direct relaxation of the blood vessels
(b) It causes dilatation of both arteries and veins
(c) Postural hypotension is not a common problem
(d) It increases plasma renin activity
77. The following statement is not true about the use of
clonidine in the treatment of hypertension:
(AIIMS May, 2003)
(a) Reduction in central sympathetic outflow
(b) Increase in LDL-cholesterol on prolonged use
(c) Sedation and xerostomia are common side effects
(d) It can be combined with vasodilators
78. A 60-year old hypertensive patient on angiotensin II
receptor antagonist (losartan) is posed for hernia repair
surgery. The antihypertensive drug should be:
(AIIMS May, 2003)
(a) Continued till the day of operation
(b) Discontinued 24 hrs preoperatively
(c) Discontinued one week preoperatively
(d) Administered in an increased dosage on the day of
operation
79. An elderly hypertensive has diabetes mellitus and
bilateral renal artery stenosis. The best management is:
(a) Enalapril (AIIMS May, 2001)
(b) Verapamil
(c) Beta blockers
(d) Thiazides
80. Drugs that can be used for the treatment of hypertension
in a diabetic patient are: (PGI Dec. 2007)
(a) Losartan
(b) Captopril
(c) Amlodipine
(d) Hydrochlorthiazide
(e) Metoprolol
81. Antihypertensive drugs beneficial or having neutral
role in lipid metabolism: (PGI Dec. 2004)
(a) Prazosin
(b) Propanolol
(c) Furosemide
(d) Losartan
(e) Chlorthiazide
82. Combination use of beta blockers and calcium channel
blockers cause: (PGI Dec. 2001)
(a) Heart block
(b) Hypertension
(c) Hypotension
(d) Bradycardia
(e) Tachyarrhythmias
83. Which of the following is true regarding enalapril
treatment in patients of essential hypertension?
(a) Decreased angiotensin II concentration in the blood
(b) Decreased concentration of renin in the blood
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