Review of Pharmacology - 9E (2015)

Review of Pharmacology
MULTIPLE CHOICE QUESTIONS
Cardiovascular System
CONGESTIVE HEART FAILURE
1. Which among the following is the best inotrope drug
for use in right heart failure? (All India 2011)
(a) Dobutamine
(b) Digoxin
(c) Dopamine
(d) Milrinone
2. All of the following are seen in digitalis toxicity
except: (All India 2011)
(a) Ventricular bigeminy
(b) Paroxysmal atrial tachycardia with fast ventricular
rate
(c) Regularization of atrial fibrillation
(d) Bidirectional ventricular tachycardia
3. All are true about starting of beta-blocker therapy in a
patient with congestive heart failure except:
(AIIMS Nov 2010)
(a) They should be started with optimum doses
(b) They should be gradually increased over weeks
(c) Special precautions should be taken in cases of
NYHA class III and IV
(d) Carvedilol and metoprolol are the preferred drugs.
4. The positive inotropic effect of digitalis is due to
inhibition of Na + /K + ATPase pump in cardiac muscle
cell membrane leading to: (DPG 2011)
(a) Decreased activity of Na + /Ca ++ exchanger causing
decreased influx of sodium and decreased efflux of
Ca ++ in the sarcolemma
(b) Decreased efflux of Na + leading to less negative
resting membrane potential and opening of voltage
gated Ca ++ channels on the T tubules
(c) Increased intracellular Na + causing increased efflux
of Na + and increased influx of Ca ++ through Na + /
Ca ++ exchanger in the sarcolemma
(d) Increased intracellular Na + decreasing the activity of
Ca ++ pump in the sarcoplasmic reticulum
5. All of the following drugs are used for the treatment of
congestive heart failure except: (AIIMS Nov 2009
(a) Nitroglycerine
(b) Spironolactone
(c) Nesiritide
(d) Trimetazidine
6. Digoxin toxicity is increased by all except:
(AIIMS May 2010, 2009) (AIIMS Nov 2008) (DNB 2008)
(a) Renal impairment
(b) Hyperkalemia
(c) Hypercalcemia
(d) Hypomagnesemia
7. Which of the following is a venodilator? (DPG 2009)
(a) Hydralazine
(b) Minoxidil
(c) Nitroprusside
(d) Nifedipine
8. All of the following statements about nesiritide are true
EXCEPT: (AI 2007, AI 2005)
(a) It is a BNP analogue
(b) It can be used in decompensated CHF
(c) It can be administered orally
(d) It causes loss of Na + in the urine
9. The following drugs have significant drug interactions
with digoxin except: (AI 2005)
(a) Cholestyramine
(b) Thiazide diuretics
(c) Quinidine
(d) Amlodipine
10. Digoxin is contraindicated in: (AI 2002)
(a) Supraventricular tachycardia
(b) Atrial fibrillation
(c) Congestive heart failure
(d) Hypertrophic obstructive cardiomyopathy
11. Digoxin is not indicated in: (AI 2001)
(a) Atrial flutter
(b) Atrial fibrillation
(c) High output failure
(d) PSVT
12. Digoxin action is not affected in: (AIIMS May, 2007)
(a) Hepatic disease
(b) Electrolyte disturbances
(c) Renal failure
(d) MI
13. BNP is degraded by: (AIIMS May, 2007)
(a) Neutral endopeptidase
(b) Elastase
(c) Omapatrilat
(d) ACE
14. Drugs used in CHF are: (PGI June, 2007)
(a) Nesiritide
(b) Digoxin
(c) Spironolactone
(d) Losartan
(e) Adrenaline
176
https://kat.cr/user/Blink99/