Review of Pharmacology - 9E (2015)

49. Sumatriptan is: (DPG 1999, TN 2004, MH-2007)
(a) 5HT 1D
antagonist
(b) 5HT 1A
agonist
(c) 5HT 1D
agonist
(d) 5HT 1A
antagonist
50. Drug of choice in acute severe migraine is:
(a) Ergotamine (UP 2008, Jharkhand 2005)
(b) Sumatriptan
(c) Dihydroergotamine
(d) Propranol
51. Methyl ergometrine is used in the prophylaxis of
(a) Migraine (TN 2000)
(b) Postpartum hemorrhage
(c) PIH
(d) None of the above
52. Which one of the following is true about sumatriptan?
(a) Antagonist of serotonin (TN 2005)
(b) Interacts with alpha and beta adrenergic receptors
(c) Has antimigraine activity
(d) Can be used in a patient with ischaemic heart disease
eicosanoids and nsaids
53. Which of the following statements is not true about
NSAIDs? (AIIMS May, 2005)
(a) Acetyl salicylic acid is an irreversible inhibitor of
COX enzyme.
(b) Acetylsalicylic acid reduces in vivo synthesis of
prostaglandins.
(c) Its clearance is independent of plasma concentration
(d) Antiplatelet effect of low dose aspirin is related to
pre-systemic COX inhibition
54. The therapeutic efficacy of antihypertensive drugs is
blunted by NSAIDs because they: (DPG-2011)
(a) Cause sodium excretion
(b) Increase the clearance of antihypertensive drugs
(c) Decrease the absorption of antihypertensive drugs
(d) Decrease the synthesis of vascular prostacyclin
55. Aspirin should be used with caution in the following
groups of patients because of which of the following
reason:
(DPG-2011)
(a) In diabetics because it can cause hyperglycemia
(b) In children with viral disease, because of the risk of
acute renal failure
(c) In gout, because it can increase serum uric acid
(d) In pregnancy, because of high risk of tera to genicity
56. Aspirin inhibits which of the following enzymes?
(a) Lipoprotein lipase (DPG 2009)
(b) Lipoxygenase
(c) Cyclooxygenase
(d) Phospholipase D
57. A patient on aspirin will have increase in: (AI 2007)
(a) Bleeding time
(b) Clotting time
(c) Prothrombin time
(d) Activated partial thromboplastin time:
Autacoids
58. Misoprostol is a: (AI 2006)
(a) Prostaglandin E 1
analogue
(b) Prostaglandin E 2
analogue
(c) Prostaglandin antagonist
(d) Antiprogestin
59. All of the following are correct statements except:
(a) PGs and leukotrienes are derived from arachidonic
acid (AI 2001)
(b) Cox II is induced by cytokines at the site of inflammation
(c) Cox I is an inducible enzyme
(d) Leukotrienes cause smooth muscle contraction
60. Which NSAID undergoes enterohepatic circulation?
(a) Phenylbutazone (AIIMS Nov 2006)
(b) Aspirin
(c) Ibuprofen
(d) Piroxicam
61. A 20 yr old female weighing 55kg is admitted to the
emergency department having consumed 10 g of paracetamol
together with alcohol 6 hrs earlier. A serum
paracetamol level is reported as 400 micro grams/ml.
Which of the following is correct with respect to this?
(a) Gastric lavage is mandatory (AIIMS Nov, 2004)
(b) Administration of activated charcoal
(c) Abnormalities of the kidney function are likely to be
present
(d) Hepatotoxicity is likely to occur
62. Prostaglandins have effects on a variety of tissues. The
different prostaglandins may have different effects.
Which of the following statements is not correct?
(AIIMS Nov, 2002)
(a) The human arteriolar smooth muscle is relaxed
by PGE 2
and PGI 2
whereas TXA 2
and PGF 2α
cause
vasoconstriction
(b) PGE 1
and PGI 2
inhibit platelet aggregation whereas
TXA 2
facilitate aggregation
(c) PGE 2
has marked oxytocic action while PGF 2α
has
tocolytic action
(d) PGE 2
is a bronchodilator whereas PGF 2α
is a
bronchoconstrictor
63. Therapeutic uses of prostaglandin E l
include all of the
following except: (AIIMS Nov, 2002)
(a) Medical termination of pregnancy
(b) Impotence
(c) Primary pulmonary hypertension
(d) Maintenance of patent ductus arteriosus
64. True statements about TXA 2
is: (PGI Dec. 2007)
(a) It is formed in platelets
(b) It is formed from PGG 2
/H 2
(c) It is prothrombotic
(d) It is having platelet anti-aggregatory activity
(e) Aspirin can inhibit its production
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