Review of Pharmacology - 9E (2015)

Central Nervous System
366
Review of Pharmacology
36. Morphine is used in the treatment of which one of the
following:
(a) Asthma
(b) Kyphoscoliosis
(c) Chronic cor pulmonale
(d) Left ventricular failure
37. The drug of choice in obsessive compulsive disorder is
which one of the following:
(a) Sertraline
(b) Amoxapine
(c) Hydroxyzine
(d) Alprazolam
38. Drug of choice for tonic-clonic seizures is:
(a) Sodium valproate
(b) Carbemazepine
(c) Phenobarbitone
(d) Felbamate
39. All of the following may be used for detoixification
therapy of chronic alcoholism except:
(a) Naltrexone
(b) Disulfiram
(c) Flumazenil
(d) Acamprostate
40. Which of the following anti-Parkinson drugs has the
potential to cause retro peritoneal fibrosis:
(a) Pramipexole
(b) Entacapone
(c) Bromocriptine
(d) Ropinirole
41. Which of the following is the treatment of choice
for patients with schizophrenia, who refuse to take
treatment:
(a) Clozapine
(b) Thioridazine
(c) Olanzapine
(d) Fluphenazine
42. Hallucinations, psychosis, hypertension and
tachycardia are adverse effects typically associated with
which of the following narcotics:
(a) Morphine
(b) Meperidine
(c) Pentazocine
(d) Buprenorphine
43. The drug of choice for status epilepticus is:
(a) Propofol
(b) Lorazepam
(c) Thiopentone
(d) Haloperidol
44. Drug of choice for treatment of absence seizures is:
(a) Phenytoin
(b) Valproate
(c) Ethosuximide
(d) Carbamazepine
45. Gabapentin has which mechanism of action for its
antiepileptic effect?
(a) Inhibits monoamine oxidase
(b) Blocks the re-uptake of neurotransmitters
(c) Increase the release of neurotransmitters
(d) Block Na + channels
46. A 20 years old female with generalized tonic clonic
epilepsy is well controlled of Tab. phenytoin 300 mg/
day, becomes pregnant. Pick the correct advise you
would give her:
(a) Stop Phenytoin + start Phenobarbitone and Folic
acid
(b) Stop Phenytoin + start Lamotrigine and Folic acid
(c) Stop Phenytoin + start Magnesium infusion
(d) Continue with Phenytoin and add Tab. Folic acid
and during the last 2 weeks of pregnancy give oral
Vitamin K too
47. Which is the drug of choice for maintenance therapy in
uncomplicated bipolar disorder?
(a) Sodium valproate
(b) Carbamazepine
(c) Lithium
(d) Lamotrigine
48. A 25 years old male started taking antipsychotic
(haloperidol) since last three days. He presented to
the emergency department with protruded tongue,
breathing difficulty along with spasm of neck and jaw
muscles. What could be the most likely diagnosis:
(a) Drug hypersensitivity reaction
(b) Acute dystonia
(c) Neuroleptic malignants
(d) Tardive dystonia
49. Neuroleptic malignant syndrome is characterized by:
(a) Hypothermia
(b) Labile blood pressure
(c) Bradycardia
(d) Flaccidity
50. Features of opioid intake are all of the following
except:
(a) Feeling of relaxation
(b) Euphoria
(c) Analgesia
(d) Dilated pupils
51. Administration of which antiepileptic drug is associated
with development of hyperkinesia in children:
(a) Phenytoin sodium
(b) Sodium valproate
(c) Carbamazepine
(d) Phenobarbitone
52. One of the following is not true about melatonin:
(a) Induces sleep
(b) Used in treatment of jet lag syndrome
(c) Is secreted by pituitary
(d) Is a pineal hormone
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