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Review of Pharmacology - 9E (2015)

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<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

Cardiovascular System<br />

35. Which <strong>of</strong> the following does not contribute to digoxin<br />

toxicity?<br />

(a) Hyperkalemia<br />

(b) Hypercalcemia<br />

(c) Renal failure<br />

(d) Hypomagnesemia<br />

36. Telmisartan lowers blood pressure by:<br />

(a) Inhibiting formation <strong>of</strong> angiotensin I to angiotensin II<br />

(b) Inhibiting conversion <strong>of</strong> renin to angiotensin I<br />

(c) Blocking AT 1<br />

receptors<br />

(d) Interfering with degradation <strong>of</strong> bradykinin<br />

37. Which <strong>of</strong> the following is not an inotropic drug:<br />

(a) Amrinone<br />

(b) Isoprenaline<br />

(c) Amiodarone<br />

(d) Dopamine<br />

38. Which <strong>of</strong> the following ‘statins’ has the longest half<br />

life?<br />

(a) Cerivastatin<br />

(b) Rosuvastatin<br />

(c) Atorvastatin<br />

(d) Simvastatin<br />

39. The vitamin which can be used for treatment <strong>of</strong> hypercholesterolemia<br />

is:<br />

(a) Thiamine<br />

(b) Niacin<br />

(c) Pyridoxine<br />

(d) Vitamine B 12<br />

40. Antihypertensive may act by blocking all <strong>of</strong> the following<br />

except:<br />

(a) Alpha-adrenoceptors<br />

(b) ATP dependent K + channels<br />

(c) Nor adrenaline release<br />

(d) Beta adrenoceptors<br />

41. Sildenafil’s mechanism <strong>of</strong> action can be best described<br />

as:<br />

(a) b-adrenoceptor blocking agent<br />

(b) Selective inhibitor <strong>of</strong> phosphodiesterase type 5<br />

(c) Inhibits reuptake <strong>of</strong> both serotonin and nor adrenaline<br />

(d) Selective-serotonin reuptake inhibitor<br />

42. The drug <strong>of</strong> choice in scleroderma induced hypertensive<br />

crisis is:<br />

(a) ACE inhibitors<br />

(b) Thiazides<br />

(c) b-blockers<br />

(d) Sodium nitroprusside<br />

43. Which <strong>of</strong> the following is the drug <strong>of</strong> choice in pregnancy<br />

induced hypertension:<br />

(a) Methyldopa<br />

(b) Diltiazem<br />

(c) Metoprolol<br />

(d) Enalapril<br />

44. Dobutamine is preferred over dopamine in cardiogenic<br />

shock because <strong>of</strong> its effect related to:<br />

(a) Better cardiac stimulation<br />

(b) Less peripheral vasoconstriction<br />

(c) Lower risk <strong>of</strong> cardiac arrhythmias<br />

(d) More CNS stimulation<br />

45. The rate limiting step in the biosynthesis <strong>of</strong> cholesterol<br />

is catalyzed by:<br />

(a) HMG CoA lyase<br />

(b) Acetyl CoA carboxylase<br />

(c) HMG CoA reductase<br />

(d) HMG CoA synthase<br />

46. All <strong>of</strong> the following drugs can cause gynaecomastia<br />

except:<br />

(a) Digoxin<br />

(b) Amiloride<br />

(c) Cimetidine<br />

(d) Spironolactone<br />

47. Drug to be avoided in HOCM (Hypertrophic obstructive<br />

cardiomyopathy) is:<br />

(a) Amiodarone<br />

(b) Verapamil<br />

(c) Digoxin<br />

(d) Beta-blockers<br />

48. All <strong>of</strong> the following are anti arrhythmic drugs except:<br />

(a) Lidocaine<br />

(b) Enalapril<br />

(c) Atenolol<br />

(d) Sotalol<br />

49. Which <strong>of</strong> the following antihypertensive drugs is contraindicated<br />

in pregnancy:<br />

(a) Labetalol<br />

(b) Hydralazine<br />

(c) Nifedipine<br />

(d) ACE inhibitors<br />

50. Which <strong>of</strong> the following calcium channel blocker would<br />

be useful in the treatment <strong>of</strong> supra-ventricular tachycardia<br />

by suppressing AV node conduction:<br />

(a) Amlodipine1<br />

(b) Nimodipine<br />

(c) Verapamil<br />

(d) Nifedipine<br />

51. HMG-CoA reductase is inhibited by:<br />

(a) Cholestyramine<br />

(b) Gemfibrozil<br />

(c) Lovastatin<br />

(d) Cl<strong>of</strong>ibrate<br />

52. An increase in heart rate and renin release seen in patients<br />

<strong>of</strong> CHF can be overcome by which <strong>of</strong> the following<br />

drugs:<br />

(a) Minoxidil<br />

(b) Metoprolol<br />

(c) Metolazone<br />

(d) Milrinone<br />

194<br />

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