Review of Pharmacology - 9E (2015)

Review of Pharmacology
Multiple Choice Questions
Autacoids
126
histamine and serotonin
1. Which is not a 2nd generation anti-histaminic agent?
(a) Cetirizine (AIIMS Nov 2012)
(b) Cyclizine
(c) Loratidine
(d) Fexofenadine
2. A peptide that causes increased capillary permeability
and edema is? (AI 2012)
(a) Histamine
(b) Angiotensin II
(c) Bradykinin
(d) Renin
3. Ergometrine is commonly used for: (MPPG 2003)
(a) Post Partum Hemorrhage
(b) To shorten 2nd stage of labour
(c) Dysmenorrhea
(d) Toxemia of pregnancy
4. A highway truck driver has profuse rhinorrhoea and
sneezing. Which amongst the following drugs would
you prescribe him? (AI 2002)
(a) Pheniramine
(b) Promethazine
(c) Dimenhydrinate
(d) Cetirizine
5. Which of the following is NOT a second generation
antihistaminic? (AIIMS, May 2008, AIIMS Nov 2006)
(a) Cyclizine
(b) Fexofenadine
(c) Loratidine
(d) Acrivastine
6. The H 3
receptor agonist exhibits all of the following
actions EXCEPT: (AIIMS Nov, 2002)
(a) Inhibition of H 1
receptor induced wakefulness
(b) Increase in H 1
mediated gastrin secretion
(c) Inhibition of H 1
mediated bronchoconstriction
(d) Negative chronotropic effect on atria
7. Second generation anti-histaminics used in allergic
rhinitis are: (PGI June, 2003)
(a) Azelastine
(b) Fexofenadine
(c) Chlorpheniramine maleate
(d) Desloratidine
(e) Promethazine
8. All of the following actions of histamine are mediated
through H 1
receptors except:
(a) Release of EDRF from vascular endothelium resulting
in vasodilation
(b) Direct action on vascular smooth muscle causing
vasodilation
(c) Bronchoconstriction
(d) Release of catecholamines from adrenal medulla
9. Which of the following drugs can cause hypotension by
release of histamine from mast cells?
(a) Aspirin
(b) Procaine
(c) Morphine
(d) Sulfadiazine
10. All of the following antihistaminic agents lack
anticholinergic property except:
(a) Promethazine
(b) Astemizole
(c) Levo-cetirizine
(d) Loratidine
11. The drug possessing antagonistic action at histamine,
serotonin and muscarinic receptors is:
(a) Promethazine
(b) Terfenadine
(c) Cyproheptadine
(d) Hydroxyzine
12. Mr. Surya Kant was prescribed a first generation H 1
antihistaminic drug. He should be advised to avoid:
(a) Driving motor vehicles
(b) Consuming processed cheese
(c) Strenuous physical exertion
(d) All of the above
13. All of the following statements are true about second
generation antihistaminic agents except:
(a) These do not impair psychomotor performance
(b) These possess high anti-motion sickness activity
(c) These lack anticholinergic actions
(d) These may possess additional antiallergic mechanisms
14. This antihistaminic drug can cause cardiac arrhythmia
at high dose by blocking cardiac K + channels. It is most
likely to be:
(a) Levo-cetrizine
(b) Fexofenadine
(c) Astemizole
(d) Loratidine
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