Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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114. Which prostaglandin helps in cervical ripening?<br />

(a) PGI2 (RJ 2007)<br />

(b) PGF2<br />

(c) PGE2<br />

(d) PGD2<br />

115. Development <strong>of</strong> hepatic central lobular necrosis<br />

secondary to acetaminophen overdose can be prevented<br />

effectively by which <strong>of</strong> the following if given within a<br />

few hours after ingestion: (RJ 2007)<br />

(a) N-acetylcysteine<br />

(b) Dimercaprol<br />

(c) Sodium nitrite<br />

(d) Amyl nitrite<br />

116. For pain control in a patient having history <strong>of</strong> G I<br />

bleeding, which <strong>of</strong> the following is given?<br />

(a) Nimesulide (Jharkhand 2004, 2005)<br />

(b) Ibupr<strong>of</strong>en<br />

(c) R<strong>of</strong>ecoxib<br />

(d) Pentazocin<br />

117. R<strong>of</strong>ecoxib was withdrawn due to: (Bihar 2005)<br />

(a) Ischemic heart disease<br />

(b) Renal complication<br />

(c) Liver adenoma<br />

(d) Gastric ulcer<br />

118. Which <strong>of</strong> the following statements is true <strong>of</strong> ketorolac?<br />

(Karnataka 2007)<br />

(a) Has potent anti-inflammatory activity<br />

(b) Its analgesic efficacy is equal to morphine in postoperative<br />

pain<br />

(c) Is used as preanaesthetic analgesic<br />

(d) It interacts with opioid receptor<br />

119. Use <strong>of</strong> aspirin in children with viral disease is associated<br />

with: (DPG 1999)<br />

(a) Metabolic acidosis<br />

(b) Reye’s syndrome<br />

(c) Renal tubular acidosis<br />

(d) Fixed drug eruption<br />

rheumatoid arthritis and gout<br />

120. Which <strong>of</strong> the following drugs cause oligospermia?<br />

(a) Leflunomide (AIIMS May 2010)<br />

(b) D-Penicillamine<br />

(c) Methotrexate<br />

(d) Sulfasalazine<br />

121. Allopurinol prevents conversion <strong>of</strong>: (PGI June, 2004)<br />

(a) Hypoxanthine to xanthine<br />

(b) Xanthine to hypoxanthine<br />

(c) Hypoxanthine to I.M.P.<br />

(d) Xanthine to uric acid<br />

122. Long term use <strong>of</strong> aspirin in rheumatoid arthritis is<br />

limited by its propensity to cause:<br />

(a) Metabolic acidosis<br />

(b) Hypersensitivity reactions<br />

(c) Gastric mucosal damage<br />

(d) Salicylism<br />

Autacoids<br />

123. Which <strong>of</strong> the following disease modifying antirheumatoid<br />

drugs is a prodrug?<br />

(a) Etanercept<br />

(b) Nimesulide<br />

(c) Sulfasalazine<br />

(d) Colchicine<br />

124. All <strong>of</strong> the following drugs can produce hyperuricemia<br />

except:<br />

(a) Ethambutol<br />

(b) Pyrazinamide<br />

(c) Sulfinpyrazone<br />

(d) Hydrochlorothiazide<br />

125. Drug <strong>of</strong> choice for acute gout is:<br />

(a) Colchicine<br />

(b) Indomethacin<br />

(c) Allopurinol<br />

(d) Dexamethasone<br />

126. Most common dose limiting adverse effect <strong>of</strong> colchicine<br />

is:<br />

(a) Sedation<br />

(b) Kidney damage<br />

(c) Diarrhea<br />

(d) Muscle paralysis<br />

127. Which <strong>of</strong> the following drugs is useful in chronic gout<br />

but is not a uricosuric agent?<br />

(a) Probenecid<br />

(b) Phenylbutazone<br />

(c) Sulfinpyrazone<br />

(d) Allopurinol<br />

128. Allopurinol is useful in all <strong>of</strong> the following conditions<br />

except:<br />

(a) Cancer chemotherapy induced hyperuricemia<br />

(b) Hydrochlorothiazide induced hyperuricemia<br />

(c) Acute gouty arthritis<br />

(d) Kala –azar<br />

129. Rasburicase is a newer drug used in gout. It act by:<br />

(a) Decreasing urate synthesis<br />

(b) Increasing urate oxidation<br />

(c) Decreasing intestinal absorption <strong>of</strong> uric acid<br />

(d) Increasing renal excretion <strong>of</strong> uric acid<br />

130. A drug that is effective for rheumatoid arthritis but is<br />

not appropriate for osteoarthritis is:<br />

(a) Acetaminophen<br />

(b) Infliximab<br />

(c) Keterolac<br />

(d) R<strong>of</strong>ecoxib<br />

131. A drug X is useful in the treatment <strong>of</strong> rheumatoid<br />

arthritis. It is available only in parenteral formulation<br />

and its mechanism <strong>of</strong> action is antagonism <strong>of</strong> tumor<br />

necrosis factor. Which <strong>of</strong> the following can be X?<br />

(a) Cyclosporine<br />

(b) Penicillamine<br />

133<br />

General Autacoids <strong>Pharmacology</strong><br />

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