Review of Pharmacology - 9E (2015)

Review of Pharmacology
Multiple Choice Questions
Chemotherapy B: Antimicrobials for Specific Conditions
anti-mycobacterial drugs
1. A middle aged man with chronic renal failure is diagnosed
to have sputum-positive pulmonary tuberculosis.
His creatinine clearance is 25 ml/min. All of the following
drugs need modification in doses EXCEPT:
(a) Isoniazid (AIIMS May, 2003)
(b) Streptomycin (AIIMS Nov, 2001) (DPG 2001)
(c) Rifampicin
(d) Ethambutol
2. Which of the following drugs is most likely to be effective
against multidrug-resistant strains of M. tuberculosis,
including those resistant to streptomycin?
(a) Amikacin (AIIMS May, 2012)
(b) Clarithromycin
(c) Gentamicin
(d) Spectinomycin
3. Slow acetylators of isoniazid are more prone to develop:
(a) Failure of therapy (AI 2012)
(b) Peripheral neuropathy
(c) Hepatotoxicity
(d) Allergic reactionsl
4. Prolonged treatment with INH leads to deficiency of?
(a) Pyridoxine (AI 2011)
(b) Thiamine
(c) Pantothenic acid
(d) Niacin
5. Pseudojaundice is an adverse effect of: (DPG - 2011)
(a) Phenytoin
(b) Rifabutin
(c) Omeprazole
(d) Chlorpromazine
6. Commonest side effect of Dapsone is: (DPG - 2011)
(a) Hemolytic anemia
(b) Thrombocytopenia
(c) Cyanosis
(d) Bone marrow depression
7. Cross resistance of isoniazid is seen with:
(a) Rifampicin (AIIMS May 2008)
(b) Ethionamide
(c) Cycloserine
(d) Ethambutol
8. Ethambutol causes: (DPG 2009)
(a) Retrobulbar neuritis
(b) Deafness
(c) Red urine
(d) Peripheral neuritis
9. Which of the following antitubercular drugs is safe in
hepatitis? (DPG 2009)
(a) Isoniazid
(b) Rifampicin
(c) Pyrazinamide
(d) Ethambutol
10. A 30 year old pregnant woman develops tuberculosis.
Which of the following antitubercular drugs should not
be used? (AI 2004)
(a) INH
(b) Rifampicin
(c) Streptomycin
(d) Ethambutol
11. Patients suffering from multidrug resistant tuberculosis
can be treated with all the following drugs EXCEPT:
(a) Tobramycin (AI 2004)
(b) Amikacin
(c) Ciprofloxacin
(d) Clarithromycin
12. Which anti-tubercular drug is implicated in the causation
of transient memory loss? (AIIMS Nov 2006)
(a) Ethionamide
(b) Isoniazid
(c) Ethambutol
(d) Pyrazinamide
13. All of the following are true about the therapy of
tuberculosis EXCEPT: (AIIMS Nov, 2004)
(a) Flu like syndrome is usually seen with rifampicin
being taken on daily basis
(b) Ethambutol accumulates in renal failure
(c) Hyperuricemia is a recognized side effect of pyrazinamide
(d) Red green color impairment is an early sign of
ethambutol induced optic neuritis
14. In leprosy, the best bactericidal agent is:
(a) Clofazimine (AI 2003, AIIMS May, 2002)
(b) Dapsone
(c) Rifampicin
(d) Ethionamide
15. A patient suffering from AIDS is on zidovudine, lamivudine
and indinavir therapy. He develops pulmonary
tuberculosis for which treatment is started. Which of
the following should be avoided in him?
(a) INH (AIIMS Nov, 2001 and May, 2003)
(b) Ethambutol
(c) Pyrazinamide
(d) Rifampicin
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