Review of Pharmacology - 9E (2015)

80. The anticoagulant of choice in pregnancy is:
(a) Heparin (UP 2007, UP 2006, RJ 2006,
(b) Warfarin Karnataka 2005)
(c) Dicumarol
(d) Phenindione
81. Which of the following drugs does not cross placenta?
(a) Heparin (UP 2008)
(b) Warfarin
(c) Dicumarol
(d) Nicoumalone
82. All of the following are anticoagulants, except:
(a) Phytonadione (TN 2007)
(b) Warfarin
(c) LMW heparin
(d) Lepirudin
83. Orally acting direct thrombin inhibitor is?
(a) Bivalirudin (MH 2008)
(b) Ximelgatran
(c) Melagatran
(d) Argatroban
84. Heparin does not cause: (Jharkhand 2005)
(a) Osteoporosis
(b) Factor V inhibition
(c) Thrombocytopenia
(d) Prolongation of aPTT
85. All of the following are seen with heparin therapy
except: (AP 2002)
(a) Skin necrosis
(b) Thrombosis and thrombocytopenia
(c) Osteoporosis
(d) Alopecia
86. Which of the following is NOT an adverse effect of
heparin? (MP 2008)
(a) Bleeding
(b) Thrombocytopenia
(c) Hypokalemia
(d) Osteoporosis
87. All of the following statements are true regarding
warfarin toxicity (skin necrosis) except: (Kolkata 2008)
(a) Skin necrosis occurs during initiation of therapy
(b) Most common sites are toes and tips of fingers
(c) Decreased quantity of protein C
(d) Decreased incidence of adverse effects if therapy
with LMWH is started.
88. Oral anticoagulants are monitored by:
(a) Bleeding time (BT) (Karnataka 2002)
(b) Coagulation time (CT)
(c) Prothrombin time (PT)
(d) Partial thromboplastin time (PTT)
89. Structurally, heparin is: (Karnataka 2001)
(a) Homopolysaccharide
(b) Heteropolysaccharide
(c) Glycoprotein
(d) Mucoprotein
Hematology
90. Low molecular weight heparin inhibits clotting factor:
(a) IIa (Karnataka 2001)
(b) IXa
(c) Xa
(d) Both (a) and (c)
fibrinolytis and miscellaneous
91. Thrombolytics can provide relative mortality reduction
in the treatment of acute myocardial infarction, if
patient comes within: (AIIMS May 2012)
(a) 6 hours
(b) 12 hours
(c) 18 hours
(d) 24 hours
92. Which of the following drugs is not recommended in
septic shock: (DPG 2009)
(a) Normal saline
(b) Activated protein C
(c) Steroids
(d) Rituximab
93. Treatment of choice in a patient of acute pulmonary
embolism with right ventricular hypokinesia and a compromised
cardiac output but normal blood pressure is:
(a) Thrombolytic agent (DPG 2007, AIIMS Nov, 2001)
(b) Low molecular weight heparin
(c) IV filters
(d) Warfarin
94. Dextran is a good plasma expanders, but it has
disadvantage of: (PGI Dec. 2006)
(a) Interference with blood group matching
(b) Causes thrombocytopenia
(c) Decreases microcirculation
(d) Promote roleaux formation
95. If a fibrinolytic drug is used for the treatment of acute
myocardial infarction, the adverse effect most likely to
occur is:
(a) Acute renal failure
(b) Development of antiplatelet antibodies
(c) Encephalitis secondary to liver dysfunction
(d) Hemorrhagic stroke
96. Which of the following medications would be prescribed
most frequently to patients suffering from
chronic atrial fibrillation?
(a) Lidocaine
(b) Bretylium
(c) Warfarin
(d) Adenosine
97. Streptokinase was infused in a patient for the
management of deep vein thrombosis, following which
the patient developed hematemesis. Which of the
given agents can be chosen to manage this episode of
hematemesis?
(a) Vitamin K
(b) Noradrenaline
(c) Epsilon amino caproic acid
(d) Rutin
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General Hematology Pharmacology
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