Review of Pharmacology - 9E (2015)

Endocrinology
272
Review of Pharmacology
62. Which of the following drugs is taken during the first
part of the meal for the purpose of delaying absorption
of dietary carbohydrates?
(a) Acarbose
(b) Glipizide
(c) Nateglinide
(d) Pioglitazone
63. Which of the following patients is most likely to be
treated with intravenous glucagon?
(a) A young man who took cocaine and has a blood
pressure of 190/110 mm Hg
(b) A middle aged man with type II diabetes who has
not taken his regular dose of glipizide for last 4 days
(c) An old man with severe bradycardia and hypotension
resulting from ingestion of overdose of atenolol
(d) An old woman with lactic acidosis as a complication
of severe infection and shock
64. Insulin acts by stimulation of:
(a) Ionotropic receptor
(b) Enzymatic receptor
(c) Metabotropic receptor
(d) Nuclear receptor
65. The most common route of administration of insulin is:
(a) Intradermal
(b) Subcutaneous
(c) Intramuscular
(d) Intravenous
66. Human insulin as compared to pork/beef insulin is:
(a) More potent
(b) Rapidly absorbed
(c) Longer acting
(d) More antigenic
67. Glipizide differs from chlorpropamide in that it:
(a) Is more potent
(b) Is longer acting
(c) Does not lower blood sugar in nondiabetic subjects
(d) Is less prone to cause hypoglycemic reaction
68. Which of the following characteristics make metformin
a preferred biguanide than phenformin?
(a) It is more potent
(b) It is less liable to cause lactic acidosis
(c) It does not interfere with vitamin B 12
absorption
(d) It is not contraindicated in patients with kidney
disease
69. Glibenclamide reduces blood glucose in all of the
following EXCEPT:
(a) Non diabetics
(b) Type 1 diabetics
(c) Type 2 diabetics
(d) Obese diabetics
70. Glibenclamide is preferred over chlorpropamide in the
treatment of DM because the latter is more likely to
cause:
(a) Hypoglycemia
(b) Alcohol intolerance
(c) Cholestatic jaundice
(d) All of the above
71. Metformin is not effective in lowering of blood sugar
level in which of the following patients?
(a) Non diabetics
(b) Obese diabetics
(c) Type 2 diabetics
(d) Diabetics not responding to sulfonylureas
72. Which of the following statements about nateglinide is
TRUE?
(a) It is a long acting oral hypoglycemic drug
(b) Taken just before a meal, it limits post prandial
hyperglycemia in type 2 diabetes mellitus
(c) It lowers blood glucose in both type 1 and type 2
diabetes mellitus
(d) It acts by opening K + channels in myocytes and
adipocytes
73. The correct statement regarding the present status of
oral hypoglycemics in diabetes mellitus is:
(a) They are the first choice drug in all cases
(b) They should be prescribed only if the patient refuse
insulin injections
(c) They are used in type 1 diabetes mellitus
(d) They are used first in most cases of uncomplicated
mild to moderate type 2 diabeties
74. Which of the following drugs is most likely to cause
hypoglycemia when used as a monotherapy in the
treatment of type 2 diabetes?
(a) Acarbose
(b) Glipizide
(c) Metformin
(d) Rosiglitazone
75. A 15 year old girl with type 1 diabetes is brought to
emergency complaining of dizziness. Laboratory findings
include severe hyperglycemia, ketoacidosis and
blood pH of 7.15. To achieve rapid control of severe
ketoacidosis, appropriate drug is:
(a) Crystalline zinc insulin
(b) NPH insulin
(c) Tolbutamide
(d) Ultra lente insulin
76. A 54- year old obese patient with type 2 diabetes mellitus
and a history of alcoholism probably should not receive
metformin because it can increase the risk of:
(a) Disulfiram like reaction
(b) Hypoglycemia
(c) Lactic acidosis
(d) Severe hepatic toxicity
77. Insulin causes: (DPG 2010)
(a) Na + entry into cells
(b) K + exit from cells
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