Review of Pharmacology - 9E (2015)

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Review of Pharmacology Answers of recent Questions asked by National Board 1. Ans (a) Phenytoin (Ref. KDT 7th/414) 2. Ans (b) Phosphodiesterase – 5 (Ref. KDT 7th/303) 3. Ans (b) Steroids (Ref. KDT 7th/294) 4. Ans. (d) All of the above (Ref: KDT 7/e p139) 5. Ans. (d) Tablets (Ref: CMDT 2014 p8) • Nicotine replacement is available as –– Patch –– Gum –– Lozenges –– Nasal sprays –– Inhalers 6. Ans. (a) Streptomycin (Ref: KDT 7/e p770) 7. Ans. (b) Chloroquine (Ref: KDT 7/e p823) 8. Ans. (c) Increases libido and prolongs orgasm (Ref: KDT 7/e p303-304) • Sildenafil inhibits PDE-5 and result in erection. It is not an aphrodisiac, do not increase libido. Other Topics and Adverse Effects 9. Ans. (a) Methyldopa (Ref: KDT 7/e p566) 10. Ans. (d) Paracetamol (Ref: KDT 7/e p533) 11. Ans. (b) Streptomycin (Ref: KDT 7/e p769-770) 12. Ans. (a) Amiodarone (Ref: KDT 7/e p533) 13. Ans. (d) All of the above (Ref: KDT 7/e p760, 767, 808) 14. Ans. (d) Pyrazinamide (Ref: KDT 7/e p793, 650, 516, 769) 714 https://kat.cr/user/Blink99/
CHAPTER 18 Drugs of Choice Drug of choice Reference Acetaminophen poisoning ACETYLCYSTEINE CMDT 2015/1553 Acute bronchial asthma SALBUTAMOL CMDT 2015/251 Acute gout NSAIDS (EXCEPT ASPIRIN) CMDT 2015/813 Acute hyperkalemia CALCIUM GLUCONATE CMDT 2015/872 Acute mania Neuroleptics (e.g. olanzapine) + Lithium CMDT 2015/1061 Acute severe digitalis toxicity DIGIBIND CMDT 2015/1556 Acute severe migraine SUMATRIPTAN CMDT 2015/955 ADHD METHYLPHENIDATE KDT 6th/470 Alzheimer’s disease DONEPEZIL/RIVASTIGMINE/GALLANTAMINE CMDT 2015/59 Ameobiasis – Asymptomatic intestinal Diloxanide Furoate CMDT 2015/1495 – Symptomatic intestinal Metronidazole + Diloxanide CMDT 2015/1495 – Extraintestinal (e.g. hepatic) Metronidazole + Diloxanide CMDT 2015/1495 Anaphylactic shock ADRENALINE (s.c./i.m.) CMDT 2015/487 Anti thyroid in pregnancy and breast feeding PROPYLTHIOURACIL CMDT 2015/1104 Anticoagulant for HIT ARGATROBAN/Bivalirudin CMDT 2015/542 Atonic seizures VALPROATE Harrison 18th/3262 Atropine poisoning PHYSOSTIGMINE CMDT 2015/1553 Atypical pneumonia TETRACYCLINE/ ERYTHROMYCIN Katzung 11th/797 Babesiosis Quinine + clindamycin CMDT 2015/1490 Benzodiazepine poisoning FLUMAZENIL CMDT 2015/1553 Beta blocker poisoning GLUCAGON CMDT 2015/1562 Bipolar disorder LITHIUM Harrison 18th/3540 Brucella DOXYCYCLINE + RIFAMPICIN CMDT 2015/1442 Carbamate poisoning ATROPINE CMDT 2015/1574 Cheese reaction PHENTOLAMINE KDT 6th/440, 545 Chemotherapy induced vomiting (Early phase) palonosetron CMDT 2015/1645 Chloroquine resistant malaria artemisinin combination therapy CMDT 2015/1484 Cholera TETRACYCLINE CMDT 2015/1440 Chronic lymphocytic leukemia FLUDARABINE + RITUXIMAB + cyclophosphamide CMDT 2015/520 Cisplatin induced vomiting (Delayed Phase) APREPITANt CMDT 2015/1645 Clonidine withdrawal PHENTOLAMINE KDT 6th/545 Coccidiosis – Cryptosporidiosis Paromomycin/nitazoxanide CMDT 2015/1498 – Isosporiasis Cotrimoxazole CMDT 2015/1498 – Cyclosporiasis Cotrimoxazole CMDT 2015/1498 – Microsporidiosis Albendazole CMDT 2015/1498 Contd... https://kat.cr/user/Blink99/
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Review of Pharmacology Ninth Editio
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Dedicated to My parents, wife Prave
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Preface to the Ninth Edition We wan
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Acknowledgments When emotions are p
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References • Harrison’s Princip
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Contents 1. History of Pharmacology
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CHAPTER 1 History of pharmacology S
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CHAPTER 2 General Pharmacology Phar
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General Pharmacology Note: It is si
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General Pharmacology Drug metaboliz
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General Pharmacology Order of kinet
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General Pharmacology Therapeutic Dr
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General Pharmacology Fig. 2.4: G-pr
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General Pharmacology sigmoid shaped
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General Pharmacology Phase 1: Here,
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General Pharmacology 5. Essential m
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General Pharmacology (b) Bioavailab
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General Pharmacology (c) Are highly
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General Pharmacology (c) Strong aci
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General Pharmacology (a) 50 mg/hour
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General Pharmacology 140. Phamacoge
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General Pharmacology (c) Piroxicam
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206. Which of the following drugs s
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General Pharmacology 29. In which t
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General Pharmacology Explanations 1
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General Pharmacology • Other fact
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General Pharmacology -- Suppose, 10
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General Pharmacology 77. Ans. (a) W
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= 40 L × 4 mg/L = 160 mg Clearance
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General Pharmacology 126. Ans. (c)
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General Pharmacology 154. Ans. (d)
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General Pharmacology Intolerance is
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General Pharmacology 6. Ans. (b) b
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CHAPTER 3 Autonomic Nervous System
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Autonomic Nervous System Functions
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Autonomic Nervous System • Carbac
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Autonomic Nervous System used for g
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Autonomic Nervous System -- Central
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Autonomic Nervous System • Theref
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Autonomic Nervous System • Eye: S
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Autonomic Nervous System • Dopami
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Autonomic Nervous System • Phenox
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Autonomic Nervous System Lipid Inso
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Autonomic Nervous System Drug of Ch
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Multiple Choice Questions Autonomic
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Autonomic Nervous System (c) Organo
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(c) Physostigmime (d) Hyoscine hydr
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Autonomic Nervous System (c) Tropic
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132. A drug that blocks the uptake
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165. Clonidine is used for: (Kolkat
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as an effective substitute which do
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Autonomic Nervous System 13. Which
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Autonomic Nervous System (c) Increa
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Autonomic Nervous System 9. Ans. (a
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Autonomic Nervous System 39. Ans. (
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Autonomic Nervous System - Temazepa
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Autonomic Nervous System 103. Ans.
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Autonomic Nervous System have no ef
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Autonomic Nervous System 23. Ans. (
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CHAPTER 4 Autacoids These are the s
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Autacoids All second generation ant
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Autacoids v v v v v Calcium channel
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Autacoids nary bypass. It can also
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Autacoids to presence of sulfur con
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Autacoids Rheumatoid Arthritis Rheu
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Autacoids It is a monoclonal antibo
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Autacoids Drug of choice Condition
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15. Anti-vertigo drug which modulat
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49. Sumatriptan is: (DPG 1999, TN 2
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81. All of the following effects ar
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114. Which prostaglandin helps in c
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Autacoids 148. Which of the followi
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Autacoids 30. A 15 year old boy was
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Autacoids 16. Ans. (b) Dangerous ve
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Autacoids 56. Ans. (c) Cyclooxygena
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Autacoids 85. Ans. (b) Aspirin supp
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Autacoids 125. Ans. (b) Indomethaci
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Autacoids 13. Ans. (a) Naproxen (Re
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CHAPTER 5 Cardiovascular System CON
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Cardiovascular System In atrial fib
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Cardiovascular System Treatment of
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Cardiovascular System should be use
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Cardiovascular System tive α 1 blo
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Cardiovascular System nifedipine an
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Cardiovascular System Treatment of
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Cardiovascular System ANGINA PECTOR
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Cardiovascular System BETA BLOCKERS
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Cardiovascular System The action po
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Cardiovascular System depolarized c
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Cardiovascular System • Digoxin i
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Cardiovascular System Contd... •
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Cardiovascular System DRUG OF CHOIC
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15. Digoxin toxicity is aggravated
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(c) Treat digoxin toxicity (d) Rapi
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(c) Decreases sodium and increases
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Cardiovascular System 113. All of t
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146. Which of the following drugs i
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Cardiovascular System 180. Characte
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213. In a patient with hypertriglyc
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247. ACE inhibitors cause: (PGI Dec
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Cardiovascular System 16. Dialysis
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Cardiovascular System 53. Which of
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• Nesiritide is a recombinant BNP
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Cardiovascular System 43. Ans. (d)
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Cardiovascular System 81. Ans. (a)
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Cardiovascular System -- Hypertensi
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Cardiovascular System Cyanide has v
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Cardiovascular System 13. Ans (b) P
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CHAPTER 6 Kidney Diuretics Diuretic
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Kidney Uses Main use of loop diuret
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Kidney • Amiloride is more potent
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Kidney Amiloride It is the agent of
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Kidney Multiple Choice Questions di
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30. Which of the following statemen
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66. Advantage of desmopressin over
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Kidney Explanations 1. Ans. (b) Hyp
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16. Ans. (b) Bumetanide (Ref: KDT 6
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Kidney 55. Ans (d) V 4 : Central Ne
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CHAPTER 7 Endocrinology Hormones ar
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Endocrinology Prolactin It causes g
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Endocrinology • In the liver and
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Endocrinology I 131 can be used for
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Endocrinology Drug interactions •
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Endocrinology Lactic acidosis (more
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Endocrinology 3. amylin analogs Pra
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Endocrinology Important Points Maxi
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Endocrinology • Steroids with sel
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Endocrinology • Vitamin D 2 is er
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Endocrinology Denosumab Osteoclasts
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Endocrinology • SERMs are targete
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Endocrinology Contd... • Uliprist
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Endocrinology only pills. Chances o
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Endocrinology Pharmacokinetics Test
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Endocrinology Ergot Derivatives Erg
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Endocrinology Contd... • Hyperpro
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completion of therapy, the patient
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(c) Glucose (d) Starch 47. True abo
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(c) Na + exit/K + entry (d) K + ent
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Endocrinology 113. Which of the fol
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147. Bisphosphonates act by: (AI 20
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180. Women receiving estrogen thera
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(c) Clomiphene (d) Mifepristone (RU
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246. Mechanism of Calcitriol is: (R
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Endocrinology 32. Drug used to cont
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(b) Glimepiride (c) Repaglinide (d)
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Endocrinology Explanations 1. Ans.
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Endocrinology 24. Ans. (c) Propylth
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Endocrinology • When this drug is
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Endocrinology Hypoglycemia is cause
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Endocrinology Drugs causing Addison
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Endocrinology Raloxifene is a selec
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Endocrinology • Enzyme inducers l
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Endocrinology 197. Ans. (b) Blocks
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Endocrinology A spider angioma (als
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Endocrinology 4. Ans (c) Glaucoma (
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Endocrinology 70. Ans. (c) Mifepris
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NOTES _____________________________
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CHAPTER 8 Central Nervous System Se
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Central Nervous System It is admini
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Central Nervous System • Abnormal
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Central Nervous System useful in AD
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Central Nervous System Wilson’s D
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Central Nervous System Important Dr
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Central Nervous System • Lamotrig
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Central Nervous System play a role
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Central Nervous System According to
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Central Nervous System bulimia, pre
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Central Nervous System Anti Manic D
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Central Nervous System dependence,
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Central Nervous System increase hea
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Central Nervous System Actions •
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Central Nervous System Contd... •
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(c) Alkalization of the urine will
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Central Nervous System (c) Ketamine
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79. Drug of choice for myoclonic ep
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(c) Phenytoin (d) Valproic acid 112
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146. Which of the following antipsy
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(c) Regular measurements of blood c
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210. A patient Rajnish having depre
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242. Drug useful in malignant hyper
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279. Preferred drug for alcohol wit
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314. Morphine can administered by a
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(c) Analgesia (d) Mydriasis 348. Di
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17. Antiparkinson drug known to cau
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53. Which drug is the most useful i
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Central Nervous System 15. Ans. (c)
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Central Nervous System 39. Ans. (b)
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67. Ans. (a) Phenytoin (Ref: Katzun
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97. Ans. (a) Hepatitis (Ref: KDT 6/
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Central Nervous System 145. Ans (c)
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Central Nervous System 159. Ans. (d
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Central Nervous System 187. Ans. (b
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Central Nervous System 212. Ans. (a
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Central Nervous System 258. Ans. (a
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Central Nervous System 303. Ans. (c
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Central Nervous System 326. Ans. (c
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Central Nervous System 60. Ans. (a)
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CHAPTER 9 Anaesthesia Local Anaesth
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Anaesthesia trigeminal nerve, cervi
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Anaesthesia Centrally Acting Muscle
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Anaesthesia • These drugs release
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Anaesthesia Anaesthetic MAC (% atm)
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Anaesthesia Methemoglobinemia and l
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Anaesthesia Chloroform • It is a
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Anaesthesia Contd... • It does no
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Anaesthesia Anaesthetic agents of c
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Anaesthesia Multiple Choice Questio
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33. Post dural (Spinal) puncture he
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(b) Dantrolene (c) Succinylcholine
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103. Which of the following drugs a
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Anaesthesia 138. Thiopental sodium
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Anaesthesia Explanations 1. Ans (c)
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Anaesthesia 20. Ans. (d) Seizures a
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Anaesthesia 49. Ans. (b) Meprobamat
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Anaesthesia • The patient underwe
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Anaesthesia 91. Ans. (b) Sevofluran
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Anaesthesia • In pheochromocytoma
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CHAPTER 10 Hematology HAEMATINICS T
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Hematology • Deficiency of folic
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Hematology • Main drugs acting as
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Hematology 1. Oral Anticoagulants
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Hematology • Bioavailability of u
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Hematology • Rodenticides contain
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Hematology Condition • Anemia Dru
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(c) Erythropoietin (d) Filgrastim (
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Hematology 46. Tirofiban is a: (RJ
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80. The anticoagulant of choice in
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6. Mechanism of action of clopidogr
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Hematology Explanations 1. Ans. (c)
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Hematology 17. Ans. (d) Oprelvekin
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Hematology 51. Ans. (a) Dabigatran:
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Hematology 71. Ans. (c) Warfarin (R
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Hematology 106. Ans. (c) Streptokin
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CHAPTER 11 Respiratory System Cough
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Respiratory System fast acting also
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Respiratory System LT receptor anta
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Respiratory System Condition • Br
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17. The most prominent and dose rel
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Respiratory System 52. In theophyll
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Respiratory System Explanations 1.
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Respiratory System • Inhalational
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CHAPTER 12 Gastrointestinal Tract P
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Gastrointestinal Tract Contd... --
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Gastrointestinal Tract Anti Emetic
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Gastrointestinal Tract Domperidone
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Gastrointestinal Tract Oral Rehydra
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Gastrointestinal Tract Condition
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(c) Misoprostol (d) Omeprazole 15.
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49. The most effective antiemetic f
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Gastrointestinal Tract recent Quest
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Gastrointestinal Tract Explanations
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Gastrointestinal Tract 30. Ans. (b)
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Gastrointestinal Tract 1. EarlyPhas
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Gastrointestinal Tract 17. Ans. (c)
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CHAPTER 13 Chemotherapy A: General
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Chemotherapy A: General Considerati
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contd... Drugs Binds to Mechanism o
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Contd... Chemotherapy A: General Co
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Clinical Uses Chemotherapy A: Gener
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Important Points About Antimicrobia
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128. Ans. (b) Trovafloxacin (Goodma
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CHAPTER 14 Chemotherapy B: Antimicr
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Chemotherapy B: Antimicrobials for
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Clofazimine It is a dye with lepros
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Foscarnet It is not an antimetaboli
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Human Immunodeficiency Virus (HIV)
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16. Bactericidal drugs in ATT are:
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50. Ethambutol should be used very
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120. Regarding ritonavir use in AID
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ACTs). All of the following combina
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ecent Questions asked by National B
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Explanations Chemotherapy B: Antimi
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25. Ans. (b) Ethionamide (Ref: KDT
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CHAPTER 15 Chemotherapy C: Antineop
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Chemotherapy C: Antineoplastic Drug
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4-5 years). Another distinguishing
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GnRH Antagonists Cetrorelix, ganire
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This drug was used in 1960s as a se
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Multiple Choice Questions Chemother
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37. Which of the following statemen
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Page 687 and 688: Immunomodulators 9. Antibodies Poly
Page 689 and 690: Immunomodulators Examples of each t
Page 691 and 692: Immunomodulators Clinical Diagnosis
Page 693 and 694: (b) Podophylline (c) Interferon (d)
Page 695 and 696: (c) Cytarabine (d) Cycloserine 51.
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Page 699 and 700: Immunomodulators 14. Ans. (a) Syste
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Page 703 and 704: CHAPTER 17 Other Topics and Adverse
Page 705 and 706: Other Topics and Adverse Effects Co
Page 711 and 712: 17. A 2 years old child without fev
Page 713 and 714: 54. Isotretinoin is: (PGI June, 200
Page 715 and 716: Other Topics and Adverse Effects (c
Page 717 and 718: Other Topics and Adverse Effects
Page 719 and 720: Other Topics and Adverse Effects
Page 721 and 722: Other Topics and Adverse Effects 39
Page 723 and 724: Other Topics and Adverse Effects 55
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Page 729 and 730: Drugs of Choice Contd... Hypertensi
Page 731 and 732: Contd... VRSA LINEZOLID/STREPTOGRAM
Page 733 and 734: CHAPTER 19 New Drugs 1. Abatacept:
Page 735 and 736: New Drugs 52. Canakinumab: A human
Page 737 and 738: New Drugs 100. Ecallantide: A plasm
Page 739 and 740: New Drugs 153. Laronidase: Recombin
Page 741 and 742: New Drugs 204. Peginesatide: A pept
Page 743 and 744: New Drugs been approved for the tre
Page 745 and 746: New Drugs and B lymphocytes after e
Page 747 and 748: New Drugs prevents nausea and vomit
Page 749 and 750: CHAPTER 20 Recent Topics TRICYCLIC
Page 751 and 752: Recent Topics 2. Drugs 5-HT 2 recep
Page 753 and 754: Recent Topics Arginine NOS NO + Cit
Page 755 and 756: Recent Topics Contd... Drug Tetracy
Page 757 and 758: Recent Topics -- If the patient has
Page 759 and 760: CHAPTER 21 Latest Papers AIIMS Nove
Page 761 and 762: Latest Papers explanations 1. Ans.
Page 763 and 764: • Clindamycin and erythromycin ar
Page 765 and 766: Latest Papers AIIMS May 2014 1. Whi
Page 767 and 768: Latest Papers explanations 1. Ans.
Page 769 and 770: 13. Ans. a. Hypokalemia (Ref: Harri
Page 771 and 772: NOTES _____________________________
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Page 775 and 776: Image Based Questions 1. The result
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5. A new antiarrhythmic drug is fou
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10. Amarnath, a 58 year old busines
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14. A 72-year-old male, Hemraj was
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(rapid vs slow induction of anesthe
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