Review of Pharmacology - 9E (2015)

Review of Pharmacology
Cardiovascular System
130. Which of the following statements best explains the
action of nitroglycerine on coronary vessels:
(a) It mitigates angina pectoris by increasing total coronary
flow
(b) It preferentially dilates conducting arteries without
affecting resistance arterioles
(c) It preferentially dilates autoregulatory arterioles
without affecting the larger arteries
(d) It mainly decreases the afterload
131. Isosorbide dinitrate decreases preload more than
afterload. Predominant venodilator action of nitrates is
due to the reason that:
(a) They are selectively concentrated in veins
(b) Veins express larger quantities of enzymes that
generate NO from nitrates
(c) Venous smooth muscle has greater capacity to relax
(d) All of the above are correct
132. Nitroglycerine exerts beneficial effects in classical
angina pectoris primarily by:
(a) Increase in total coronary blood flow
(b) Redistribution of coronary blood flow
(c) Reduction of cardiac preload
(d) Reduction of cardiac afterload
133. Nitroglycerine exerts beneficial effects in variant angina
primarily by:
(a) Coronary vasodilation
(b) Decreased ventricular contractility
(c) Reduction of cardiac preload
(d) Reduction of cardiac afterload
134. Organic nitrates can lead to the development of tolerance
when used chronically. Which of the following
preparations is least likely to develop tolerance:
(a) Sustained release oral nitroglycerine
(b) Sublingual nitroglycerine
(c) Transdermal nitroglycerine
(d) Oral pentaerythritol tetranitrate
135. Nitroglycerine can be administered by all of the following
routes except:
(a) Oral
(b) Sublingual
(c) Intramuscular
(d) Intravenous
136. Concomitant administration of this drug with organic
nitrates is contra-indicated due to marked potentiation
of vasodilatory action leading to profound hypotension.
This drug is:
(a) Propanolol
(b) Fluoxetine
(c) Hydrochlorothiazide
(d) Sildenafil
137. Which of the following drugs is most likely to
precipitate angina?
(a) Amlodipine
(b) Nifedipine
(c) Diltiazem
(d) Verapamil
138. All of the following statements about amlodipine are
true except:
(a) It acts by conversion to an active metabolite in the
liver
(b) It has a very large volume of distribution
(c) It undergoes very little first pass metabolism and
possesses high and consistent oral bioavailability
(d) It has a very long elimination half life
139. Propanolol is contra-indicated in a patient of angina
pectoris who is already receiving:
(a) Nifedipine
(b) Aspirin
(c) Verapamil
(d) Isosorbide mononitrate
140. True statement about trimetazidine is:
(a) It is a novel sodium channel blocker
(b) It improves tissue perfusion by modifying rheological
property of blood
(c) It is an inhibitor of fatty acid oxidation
(d) Both (a) and (b) are correct
141. An experimental drug is found to preferentially dilate
autoregulatory coronary arterioles without affecting
large conducting vessels. It is likely to:
(a) Evoke coronary steal phenomenon
(b) Mitigate classical angina but not variant angina
(c) Produce tachycardia as an adverse effect
(d) Useful in CHF
142. This drug is a classical example of pharmacological
success but therapeutic failure. Reason for its therapeutic
failure is coronary steal phenomenon. It is:
(a) Glyceryl trinitrate
(b) Dipyridamole
(c) Propanolol
(d) Diltiazem
143. Calcium channel blockers with predominant peripheral
effects is:
(a) Verapamil
(b) Diltiazem
(c) Amlodipine
(d) None of these
144. Longest acting nitroglycerine preparation is:
(a) Glyceryl trinitrate
(b) Amyl nitrite
(c) Penta erythrital tetranitrate
(d) Isosorbide dinitrate
145. A drug lacking vasodilatory properties that is effective
in angina is:
(a) Isosorbide dinitrate
(b) Metoprolol
(c) Nifedipine
(d) Verapamil
184
https://kat.cr/user/Blink99/