Review of Pharmacology - 9E (2015)

Cardiovascular System
DRUG OF CHOICE
Condition
Drug of choice
• Diabetic nephropathy
ACE inhibitors or ARBs
• Scleroderma hypertensive crisis
Captopril
• Congestive heart failure
– Decompensated Dobutamine
– Compensated ACEI/ARB
• Hypertrophic obstructive cardiomyopathy Propanolol
• Angina pectoris
– Acute attack Sublingual nitroglycerine
– Prophylaxis Oral/transdermal nitrates
• Esophageal spasm
Nitroglycerine
• Cyanide poisoning
Hydroxocobalamin/amyl nitrite
• Raynaud's phenomenon
Nifedipine ER or amlodipine
• Myocardial infarction
– Pain relief Sublingual nitroglycerine ↓ Morphine
– Prophylaxis Aspirin
– Thrombolytic for STEMI Reteplase or alteplase
• Hypertension
Thiazides
– With BHP Prazosin
– With diabetes mellitus ACE inhibitors
– With ischemic heart disease (angina) Beta blockers
– With chronic kidney disease ACE inhibitors
– In pregnancy Labetalol
• Acute severe digitalis toxicity
Digibind
• Hypertensive emergencies
Nicardipine + Esmolol
– In cheese reaction Phentolamine
– in clonidine withdrawl Phentolamine
– In aortic dissection Nitroprusside + esmolol
– In Pregnancy Labetalol
• Hyperlipidemia
– Type IIa and IIb Statins
– Type III (hypertriglyceridemia) Fibrates
– Type IV Statins
– Secondary to diabetes or nephrotic syndrome Statins
• Supraventricular tachycardia
– Narrow QRS complex Verapamil or beta blockers
– Wide complex Flecainide
– WPW syndrome Flecainide
• Paroxysmal supraventricular tachycardia (PSVT)
– Acute treatment Adenosine
– Prophylaxis Verapamil
• Ventricular tachycardia
Lignocaine
– Digitalis induced Lignocaine
• Long QT syndrome (Torsades' de pointes) Magnesium
175
General Cardiovascular Pharmacology System
https://kat.cr/user/Blink99/