Review of Pharmacology - 9E (2015)

Central Nervous System
354
Review of Pharmacology
195. The secretion of which of the following hormones increases
with chlorpromazine therapy?
(a) Prolactin
(b) Gonadotropin
(c) Corticotropin
(d) Antidiuretic hormone
196. A patient, Hari has been diagnosed to have schizophrenia.
Which of the following acts as a limiting factor in
the use of clozapine as an antipsychotic drug in this patient?
(a) Its potential to cause agranulocytosis
(b) Its inability to benefit negative symptoms of schizophrenia
(c) High incidence of extrapyramidal side effects
(d) Production of hyperprolactinemia
197. Propanolol is useful in the management of which of the
following side effects of a typical neuroleptic?
(a) Parkinsonism
(b) Acute muscle dystonia
(c) Tardive dyskinesia
(d) Akathisia
198. Which of the following adverse effect can occur even
after the offending drug has been withdrawn a long
time back?
(a) Paradoxical tachycardia
(b) Tardive dyskinesia
(c) Malignant hyperthermia
(d) Gynaecomastia
199. All of the following statements about buspirone are
incorrect EXCEPT?
(a) It interacts with benzodiazepine receptor as an inverse
agonist
(b) It is a rapidly acting anxiolytic: good for panic states
(c) It produces physical dependence and suppresses
barbiturate withdrawal syndrome
(d) It has anxiolytic but no anticonvulsant or muscle relaxant
property
200. Which of the following drugs is preferred for long term
treatment of severe anxiety disorder with intermittent
panic attacks?
(a) Phenothiazine
(b) Azapirone
(c) b blocker
(d) Selective serotonin reuptake inhibitor
201. The selective MAO-B inhibitor out of the following is:
(a) Selegiline
(b) Clorgyline
(b) Moclebemide
(d) Tranylcypromine
202. An antidepressant drug which is known to have both
high sedative and anticholinergic activity is:
(a) Phenelzine
(b) Amitriptyline
(c) Fluoxetine
(d) Trazodone
203. All of the following are limitations of typical tricyclic
antidepressants EXCEPT:
(a) Narrow safety margin
(b) Low oral bioavailability
(c) Frequent side effects
(d) Long latent period for response
204. One of the following limitations of typical tricyclic antidepressants
has been overcome by selective serotonin
reuptake inhibitors. Which is it?
(a) Frequent anticholinergic, sedative and hypotensive
side effects
(b) High risk of cardiac arrhythmias and seizures in
overdose
(c) Delayed response
(d) Both (a) and (b) are correct
205. Now-a-days, the selective serotonin reuptake inhibitors
are the preferred drugs for which of the following psychiatric
disorder apart from their role in the treatment
of depression:
(a) Phobias
(b) Obsessive compulsive disorder
(c) Post-traumatic stress disorder
(d) All of the above
206. A patient has been diagnosed to be having mania and
bipolar illness. Which of the following drugs can be
used in this patient apart from lithium?
(a) Carbamazepine
(b) Carisoprodol
(c) Clomipramine
(d) Diethylcarbamazine
207. Which of following statements about extrapyramidal
effects of antipsychotic drugs is FALSE?
(a) Caused by blockade of dopamine receptors
(b) Less likely to be produced by clozapine than by
chlorpromazine
(c) Can be countered to some degree by antimuscarinic
drugs
(d) Haloperidol does not cause extrapyramidal
syndrome
208. A psychiatric patient taking medication develops a
tremor, thyroid enlargement and leucocytosis. Drug
implicated is:
(a) Clomipramine
(b) Haloperidol
(c) Lithium
(d) Olanzapine
209. MAO inhibitors are contra-indicated in all the following
conditions EXCEPT:
(a) With tricyclic antidepressants
(b) With indirectly acting sympathomimetics
(c) Cheese
(d) Aspirin
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