Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Autacoids<br />

128<br />

<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

(c) Analgesic<br />

(d) Antidepressant<br />

33. Fex<strong>of</strong>enadine is metabolic product <strong>of</strong>: (Karnataka 2000)<br />

(a) Loratidine<br />

(b) Astemizole<br />

(c) Cetrizine<br />

(d) Terfenadine<br />

34. Cisapride is useful in: (Karnataka 2000)<br />

(a) Gastroesophageal reflux disease<br />

(b) Gastrointestinal spasm<br />

(c) Carcinoid syndrome<br />

(d) Gastrointestinal hypermotility<br />

35. Histamine blocker in stomach act through:<br />

(a) Decreasing cAMP in stomach (Bihar 2004)<br />

(b) Increasing cAMP in stomach<br />

(c) Increasing IP3 in stomach<br />

(d) Decreasing IP3 in stomach<br />

ergot alkaloids and migraine<br />

36. After taking some drug for acute attack <strong>of</strong> migraine, a<br />

patient developed nausea and vomiting. He also developed<br />

tingling and numbness in the tip <strong>of</strong> the finger that<br />

also turned blue. Which <strong>of</strong> the following is the most<br />

likely drug implicated in causing the above findings?<br />

(a) Dihdroergotamine (AI 2012)<br />

(b) Sumatriptan<br />

(c) Aspirin<br />

(d) Butorphanol<br />

37. Drugs used in prophylaxis <strong>of</strong> migraine are all except?<br />

(a) Propanolol (AI 2010)<br />

(b) Flunarizine<br />

(c) Topiramate<br />

(d) Levetiracetam<br />

38. All <strong>of</strong> the following can be used for prophylaxis <strong>of</strong><br />

migraine except: (AI 2010)<br />

(a) Sumatriptan<br />

(b) Valproate<br />

(c) Propanolol<br />

(d) Topiramate<br />

39. Drugs used for prophylaxis <strong>of</strong> migraine is/are:<br />

(a) Flunarizine (PGI Dec. 2004)<br />

(b) Cinarizine<br />

(c) Beta blocker<br />

(d) Sodium valproate<br />

(e) Carbamazepine<br />

40. Which <strong>of</strong> the following is most useful for reversing<br />

severe ergot induced vasospasm?<br />

(a) Ergotamine<br />

(b) Methysergide<br />

(c) Nitroprusside<br />

(d) Phenoxybenzamine<br />

41. Selective 5-HT 1B/1D<br />

receptor agonist useful in acute<br />

migraine is:<br />

(a) Buspirone<br />

(b) Ondansetron<br />

(c) Frovatriptan<br />

(d) Ketanserin<br />

42. Which <strong>of</strong> the following adverse effects is<br />

characteristically associated with methysergide?<br />

(a) Pulmonary hypertension<br />

(b) Retroperitoneal fibrosis<br />

(c) Hepatotoxicity<br />

(d) Ischemic heart disease<br />

43. Dihydroergotamine differs from ergotamine in the<br />

following respect:<br />

(a) It is a more potent oxytocic<br />

(b) It has antiemetic property<br />

(c) It has high oral bioavailability<br />

(d) It is more potent α adrenergic blocker and less potent<br />

vasoconstrictor<br />

44. Ergot alkaloid commonly used to prevent post-partum<br />

hemorrhage is:<br />

(a) Methyl ergometrine<br />

(b) Ergotamine<br />

(c) Dihydroergotamine<br />

(d) Dihydroergotoxine<br />

45. Choose the correct statement about sumatriptan:<br />

(a) It activates 5-HT 1A<br />

receptors<br />

(b) It tends to suppress both pain and vomiting in migraine<br />

(c) It does not carry risk <strong>of</strong> precipitating coronary vasospasm<br />

(d) It is combined with ergotamine for the treatment <strong>of</strong><br />

severe migraine<br />

46. Which <strong>of</strong> the following drugs is used for the prophylaxis<br />

<strong>of</strong> migraine but not for angina pectoris?<br />

(a) Verapamil<br />

(b) Diltiazem<br />

(c) Flunarizine<br />

(d) Amlodipine<br />

47. Drugs used in migraine prophylaxis are all except:<br />

(a) Flunarizine (DPG 2010, DNB 2007, Kolkata 2005)<br />

(b) Propanolol<br />

(c) Cyproheptadine<br />

(d) Sumatriptan<br />

48. Sumatriptan is used in: (DPG 2000)<br />

(a) Mania<br />

(b) Depression<br />

(c) Schizophrenia<br />

(d) Migraine<br />

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