Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

Chemotherapy C: Antineoplastic Drugs<br />

121. Proliferation independent agents include all the following<br />

except: (Karnataka 2002)<br />

(a) Vincristine<br />

(b) Carmustine<br />

(c) Melphalan<br />

(d) Cyclophosphamide<br />

122. People with high risk for development <strong>of</strong> breast cancer<br />

should be treated by prophylactic administration <strong>of</strong>:<br />

(a) Tamoxifen (Karnataka 2002)<br />

(b) Aminoglutethimide<br />

(c) Diethylstibesterol<br />

(d) Flutamide<br />

123. Which <strong>of</strong> the following is widely used in the management<br />

<strong>of</strong> carcinoma breast? (DPG 2007)<br />

(a) Actinomycin-D<br />

(b) Bleomycin<br />

(c) Doxorubicin<br />

(d) Dacarbazine<br />

124. Allopurinol potentiates action <strong>of</strong>: (DPG 2002)<br />

(a) Azathioprine<br />

(b) Busulfan<br />

(c) Actinomycin<br />

(d) Procarbazine<br />

recent Questions asked by National Board<br />

1. Which <strong>of</strong> the following anticancer drugs is not derived<br />

from plants?<br />

(a) Irinotecan<br />

(b) Doxorubicin<br />

(c) Paclitaxel<br />

(d) Etoposide<br />

2. Resistance to methotrexate develops due to ?<br />

(a) Rapid cancer cell multiplication<br />

(b) Deficiency <strong>of</strong> thymidylate kinase<br />

(c) Deficiency <strong>of</strong> thymidylate synthetase<br />

(d) Increased production <strong>of</strong> dihydr<strong>of</strong>olate reductase<br />

3. All are true regarding sunitinib except –<br />

(a) It inhibits tyrosine kinase<br />

(b) It is used for renal cell carcinoma<br />

(c) It is used for the treatment <strong>of</strong> GIST<br />

(d) It is excreted primarily in urine<br />

4. About vinca alkaloids, true is –<br />

(a) Inhibits mitotic spindle<br />

(b) Enhances polymerization <strong>of</strong> tubulin<br />

(c) Inhibits topoisomerase I<br />

(d) Inhibits topoisomerase II<br />

5. Mesna is used in –<br />

(a) Hemorrhagic cystitis<br />

(b) Acute promyelocytic leukemia<br />

(c) Serous otitis media<br />

(d) Polycythemia vera<br />

6. Finasteride is a:<br />

(a) 5-a reductase inhibitor<br />

(b) Phosphodiesterase inhibitor<br />

(c) Alpha blocker<br />

(d) Androgen receptor blocker<br />

7. Which <strong>of</strong> the following anti-neoplastic drugs SHOULD<br />

NOT be given by rapid IV infusion ?<br />

(a) Cyclophosphamide<br />

(b) Cisplatin<br />

(b) Bleomycin<br />

(d) Cytosine arabinoside<br />

8. Mechanism <strong>of</strong> a action <strong>of</strong> vincristine is –<br />

(a) Tubulin inhibitor<br />

(b) Antimetabolite<br />

(c) Adenylate cyclase inhibitor<br />

(d) Anti folate<br />

9. Which <strong>of</strong> the following antineoplastic and<br />

immunosuppressant drugs is a dihydr<strong>of</strong>olate reductase<br />

inhibitor?<br />

(a) Methotrexate<br />

(b) Adriamycin<br />

(c) Vincristine<br />

(d) Cyclophosphamide<br />

10. The drug <strong>of</strong> choice in choriocarcinoma is:<br />

(a) Methotrexate<br />

(b) Actinomycin-D<br />

(c) Vincristine<br />

(d) 6-Thioguanine<br />

11. Microtubule formation is inhibited by:<br />

(a) Paclitaxel<br />

(b) Vincristine<br />

(c) Etoposide<br />

(d) Irinotectan<br />

12. Imatinib primarily acts by inhibiting:<br />

(a) BCR-ABL<br />

(b) Tyrosine kinase<br />

(c) PGDFR<br />

(d) None<br />

13. True about Bicalutamide is:<br />

(a) Binds to androgen receptor<br />

(b) Causes gynaecomastia<br />

(c) It can be given as monotherapy in prostatic carcinoma<br />

(d) All are true<br />

14. Drug <strong>of</strong> choice for neutropenia due to cancer<br />

chemotherapy is:<br />

(a) Vitamin B-12<br />

(b) IL-11<br />

(c) Filgrastim<br />

(d) Erythropoietin<br />

658<br />

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