Review of Pharmacology - 9E (2015)

Review of Pharmacology
(Conn’s Syndrome). Aldosterone excess will cause hypertension, hypokalemia, metabolic alkalosis and depressed renin.
Aldosterone antagonists such as spironolactone or eplerenone can be used as medical therapy for Conn’s syndrome.
68. Ans. (b) Desmopressin (Ref: CMDT-2010/792)
Desmopressin is ADH and will exacerbates the symptoms of SIADH. Hypertonic saline (3%NaCl) is used for severely
symptomatic patients with hyponatremia. Demeclocycline decreases the release of ADH.
69. Ans. (a) Furosemide (Ref: KDT, 6/e p566)
Answers of recent Questions asked by National Board
Kidney
1. Ans (a) Vasopressin antagonist (Ref. CMDT 7th/866)
2. Ans (a) Thiazide (Ref. KDT 7th/598)
3. Ans (a) Metabolic alkalosis (Ref. KDT 7th/585)
4. Ans (b) More selective for V 1
receptor (Ref. KDT 7th/596)
5. Ans (d) Hypocalcemia (Ref. KDT 7th/585)
6. Ans. (d) Cortical collecting duct (Ref: KDT 7/e p594)
7. Ans. (c) Desmopressin (Ref: KDT 7/e p 597)
8. Ans. (b) Structural resemblance to sulfonamides (Ref: KDT 7/e p586-87)
• Acetazolamide is non-competitive but reversible inhibitor of carbonic anhydrase
• It is a sulfonamide derivative
• It causes hypokalemia and metabolic acidosis.
9. Ans. (a) Hypercalcemia (Ref: KDT 7/e p584-585)
10. Ans. (d) Hypertonic saline (Ref: CMDT 2014/842)
11. Ans. (d) All of the above (Ref: KDT 7/e p584-585)
12. Ans. (d) Triamterene (Ref: KDT 7/e p589)
13. Ans. (d) Pulmonary hypertension (Ref: KDT 7/e p582)
14. Ans. (a) Pulmonary edema (Ref: KDT 7/e p588-589)
15. Ans. (d) Indapamide (Ref: KDT 7/e p579)
16. Ans. (c) Collecting tubule (Ref: KDT 7/e p594)
17. Ans. (b) Spironolactone (Ref: KDT 7/e p579)
18. Ans. (c) Thiazide (Ref: KDT 7/e p584)
19. Ans. (c) Ascending limb of loop of Henle (Ref: KDT 7/e p579)
20. Ans. (a) Furosemide (Ref: KDT 7/e p581)
21. Ans. (b) DCT (Ref: KDT 7/e p582)
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