Review of Pharmacology - 9E (2015)

132. A drug that blocks the uptake of dopamine and
norepinephrine into presynaptic nerve terminals and
also blocks sodium channels in the axonal membrane
is:
(a) Cocaine
(b) Ephedrine
(c) Imipramine
(d) Fluoxetine
133. Intravenous administration of norepinephrine in a
patient already taking an effective dose of atropine will
often:
(a) Increase heart rate
(b) Decrease total peripheral resistance
(c) Decrease pupil size
(d) Has no effect on cardiovascular system
134. A patient Pushpa comes to you in the medicine emergency
and you diagnose her to be suffering from severe
CHF. You choose a drug ‘Z’ which is a short term ionotropic
agent having selective adrenergic β 1
agonistic activity
but lacking dopaminergic agonistic activity. What
can be ‘Z’?
(a) Dopamine
(b) Dobutamine
(c) Amrinone
(d) Salmeterol
135. A patient Ram kali presents with the symptoms suggestive
of pheochromocytoma. Her urine metanephrine
and vinylmandelic acid levels are above normal but
normetanephrine level is less than normal. She later
presents to you in emergency with chest pain and severe
headache. An ECG indicates MI. Her blood pressure is
220/160 mm Hg and the heart rate is 160/ min. On examination
she appears to be dehydrated also. The doctor
attending her gives her phentolamine i.v. Within 8-10
min, she goes in a state of shock with her blood pressure
being 36/0 mm Hg. Vasoconstrictors are ineffective
and she dies within 4 hrs. Which of the following best
explains the exaggerated response to phentolamine in
this patient?
(a) Escape of the autonomic nervous system control
over blood pressure
(b) Metastasis of the tumor to the vasomotor centre in
medulla
(c) Patient’s tumor secreting almost pure adrenaline and
no noradrenaline
(d) Overdose of phentolamine because of the rarity of
such cases in the emergency
136. Dopamine is preferred in treatment of shock because
of: (DPG 2010) (UP 2008)
(a) Renal vasodilatory effect
(b) Increased cardiac output
(c) Peripheral vasoconstriction
(d) Prolonged action
Autonomic Nervous System
137. Which of the following increases systolic and diastolic
BP for prolonged period?
(DELHI-PG-2008)
(a) Epinephrine
(b) Dopamine
(c) Ephedrine
(d) All of these
138. TRUE statement regarding use of adrenaline in
anaphylactic shock is:
(DPG-2007)
(a) The usual dose is 0.5-1 mg by i.m. route
(b) Cerebral hemorrhage never occurs as an adverse effect
to epinephrine when used in treatment of anaphylactic
shock
(c) It is repeated after every 2-4 hours
(d) Same solution can be given for s.c. as well as i.v.
route
139. Renal dose of dopamine is: (DPG 2005)
(a) 2.5 µg/kg/min
(b) 5-10 µg/kg/min
(c) 10-20 µg/kg/min
(d) 1-2 µg/kg/min
140. Half life of Dobutamine is: (DPG 2004)
(a) 120 seconds
(b) 200 seconds
(c) 20 seconds
(d) 20 minutes
141. All are side effects of salbutamol EXCEPT: (DPG 2003)
(a) Palpitation
(b) Muscle tremors
(c) Sedation
(d) Throat irritation
142. Treatment of choice for anaphylactic shock is:
(a) Intravenous hydrocortisone (DPG 2003)
(b) Subcutaneous adrenaline
(c) Intravenous aminophylline
(d) Subcutaneous antihistaminic
143. Norepinephrine action at the synaptic cleft is terminated
by: (DPG 2001)
(a) Metabolism by COMT
(b) Metabolism by MAO
(c) Reuptake
(d) Metabolism by acetylcholinesterase
144. Epinephrine is most useful in: (DPG 1998)
(a) Bronchial asthma
(b) Anaphylactic shock
(c) Peripheral vascular disease
(d) Wide angle glaucoma
145. Exogenous adrenaline is metabolized by: (DPG 1998)
(a) AChE
(b) COMT
(c) Decarboxylase
(d) Acetyl transferase
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Autonomic General Pharmacology
Nervous System
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