Review of Pharmacology - 9E (2015)

General Pharmacology
22
Review of Pharmacology
30. High hepatic extraction ratio is seen in: (PGI June, 2002)
(a) Propanolol
(b) Lidocaine
(c) Ampicillin
(d) Imipramine
(e) Theophylline
31. Regarding termination of drug action:
(a) Drugs must be excreted from the body to terminate
their action
(b) Metabolism of drugs always abolishes their pharmacologic
activity
(c) Hepatic metabolism and renal excretion are the two
most important mechanisms involved
(d) Distribution of a drug out of blood stream terminates
the drug’s effects
32. The process by which the amount of a drug in the body
decreases after administration but before entering the
systemic circulation is called:
(a) Excretion
(b) First pass effect
(c) First order elimination
(d) Metabolism
33. The most general term for the process by which the
amount of active drug in the body is reduced after
absorption into the systemic circulation is:
(a) Excretion
(b) Elimination
(c) First pass metabolism
(d) Distribution
34. Titration of the dose of a drug with the response
can be done with which of the following routes of
administration:
(a) Sublingual
(b) Transdermal
(c) Inhalational
(d) Subcutaneous
35. Urinary alkalinizing agents are administered in case of
poisoning due to drugs which are:
(a) Weak bases
(b) Weak acids
(c) Strong bases
(d) Strong acids
36. Which of the following drugs has maximum chances of
absorption from gastric mucosa?
(a) Morphine sulfate
(b) Diclofenac sodium
(c) Hyoscine hydrobromide
(d) Quinine dihydrochloride
37. All of the following factors tend to increase the volume
of distribution of a drug EXCEPT:
(a) High plasma protein binding
(b) Low ionization at physiological pH values
(c) High lipid solubility
(d) High tissue binding
38. Which of the following drugs is commonly administered
by intranasal route?
(a) Adrenaline
(b) Desmopressin
(c) Ganirelix
(d) Insulin
39. Major mechanism of transport of drugs across biological
membranes is by:
(a) Passive diffusion
(b) Facilitated diffusion
(c) Active transport
(d) Endocytosis
40. A drug X is secreted through renal tubules, tubular
secretion of this drug can be confirmed if renal clearance
of drug X is:
(a) More than the GFR
(b) Equal to the GFR
(c) Less than the GFR
(d) More than volume of distribution
41. Metabolism of a drug primarily results in:
(a) Activation of the active drug
(b) Conversion of prodrug to active metabolite
(c) Conversion of lipid soluble drugs to water soluble
metabolites
(d) Conversion of water soluble drug to lipid soluble
metabolites
42. A new drug is found to be highly lipid soluble. It is
metabolized at a slower rate of 10% per hour. On
intravenous injection it produces general anaesthesia
that lasts only for 15 min. This short duration of
anaesthesia is due to:
(a) Metabolism of the drug in liver
(b) High plasma protein binding of the drug
(c) Excretion of drug by kidney
(d) Redistribution
43. All of the following are advantages of transdermal drug
delivery systems EXCEPT:
(a) They produce high peak plasma concentration of the
drug
(b) They produce smooth and nonfluctuating plasma
concentration of the drug
(c) They minimize interindividual variations in the
achieved plasma drug concentration
(d) They avoid hepatic first pass metabolism of the drug
44. Thiopentone is used for induction of anaesthesia. It
shows marked redistribution which is a characteristic
of:
(a) Highly lipid soluble drugs
(b) Highly water soluble drugs
(c) Weak electrolytes
(d) Highly plasma protein bound drugs
45. True statement about weakly basic drugs is:
(a) These are bound primarily to plasma albumin
(b) These are excreted faster in acidic urine
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