Review of Pharmacology - 9E (2015)

Chemotherapy B: Antimicrobials for Specific Conditions
608
Review of Pharmacology
anti-hiv drugs
103. All of the following are common adverse effects of
HAART therapy except:
(a) Steatosis
(b) Lipodytrophy
(c) Optic neuritis
(d) Increased cholesterol
104. A person is being treated for Human Immunodeficiency
Virus-1. He developed hypertriglyceridemia and
hypercholesterolem0ia. Most likely drug implicated for
these adverse effects is: (AI 2012)
(a) Ritonavir
(b) Raltegravir
(c) Didanosine
(d) Efavirenz
105. Efavirenz is used for treatment of HIV infections. It acts
(a) As protease inhibitor (AIIMS Nov. 2011)
(b) As reverse transcriptase inhibitor
(c) As integrase inhibitor
(d) By inhibiting the HIV entry into the cell
106. Which of the following drugs is used to prevent HIV
transmission from an HIV positive pregnant mother to
child? (AIIMS Nov. 2011)
(a) Lamivudine
(b) Stavudine
(c) Nevirapine
(d) Didanosine
107. Which is the integrase inhibitor used in treatment of
HIV? (AI 2011)
(a) Raltegravir
(b) Indinavir
(c) Lopinavir
(d) Fosamprenavir
108. All of the following cause inhibition of CYP3A except:
(a) Saquinavir (AIIMS May 2010)
(b) Ritonavir
(c) Itraconazole
(d) Erythromycin
109. Which of the following drug is a reverse transcriptase
inhibitor? (DPG - 2011)
(a) Indinavir
(b) Ritonavir
(c) Nelfinavir
(d) Abacavir
110. Maximum risk of pancreatitis is present with:
(a) Didanosine (AI 2010)
(b) Lamivudine
(c) Zidovudine
(d) Abacavir
111. The basis of combining ritonavir with lopinavir:
(a) Pharmaceutical compatibility (DPG 2009)
(b) C4P3A4 inhibition by ritonavir
(c) Long elimination half life of ritonavir
(d) Ability to counteract side-effects of lopinavir
112. Nevirapine is: (AI 2007, 2006, 2005)
(a) Non-nucleoside reverse transcriptase inhibitor
(NNRTI) (AIIMS May 2004, RJ 2008)
(b) Nucleoside reverse transcriptase inhibitor (NRTI)
(c) Protease inhibitor
(d) Fusion inhibitor
113. Drug causing maximum peripheral neuropathy is:
(a) Zidovudine (AI 2007)
(b) Lamivudine
(c) Stavudine
(d) Didanosine
114. All of the following drugs are protease inhibitors
EXCEPT: (AI 2006)
(a) Nelfinavir
(b) Saquinavir
(c) Abacavir
(d) Ritonavir
115. Which of the following anti-retroviral drugs does not
cause peripheral neuropathy? (AI 2000)
(a) Lamivudine
(b) Stavudine
(c) Didanosine
(d) Zalcitabine
116. True about protease inhibitors are all except:
(AIIMS Nov., 2007)
(a) Acts as a substrate for P-glycoprotein(P-gp) and
action is mediated by mdr-1 gene
(b) undergo hepatic oxidative metabolism
(c) Protease inhibitors interfere with metabolism of
several drugs
(d) Saquinavir causes maximum induction of CYP3A4
117. Resistance to zidovudine develops due to:
(AIIMS May, 2005)
(a) Mutation at reverse transcriptase
(b) Increased efflux of the drug from inside the cell
(c) Increased metabolism of the drug
(d) Decreased zidovudine 5 triphosphate formation
118. Complications of zidovudine therapy are:
(a) Nausea and vomiting (PGI June, 2006)
(b) Anemia
(c) Steatosis
(d) Nephrotoxicity
(e) Cardiotoxicity
119. Nucleoside reverse transcriptase inhibitors are:
(a) Zalcitabine (PGI June, 2004)
(b) Delavirdine
(c) Nevirapine
(d) Stavudine
(e) Ritonavir
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