Review of Pharmacology - 9E (2015)

Chemotherapy C: Antineoplastic Drugs
654
Review of Pharmacology
(c) Inhibition of DNA mediated RNA synthesis
(d) Inhibition of polymerization of tubulin to form microtubules
53. All of the following statements about vincristine are
true EXCEPT:
(a) It acts by inhibiting mitosis
(b) Its prominent adverse effect is peripheral neuropathy
(c) It does not suppress bone marrow
(d) It is a drug of choice for solid tumors.
54. All of following statements about are true about
6-mercaptopurine EXCEPT:
(a) It is metabolized by xanthine oxidase
(b) It does not cause hyperuricemia
(c) Its dose should be reduced when allopurinol is given
concurrently
(d) It is an active metabolite of azathioprine
55. Pentostatin acts by inhibiting:
(a) RNA dependent DNA polymerase
(b) Aldolase
(c) Adenosine deaminase
(d) Adenylyl cyclase
56. Hand and foot syndrome is an adverse effect of:
(a) 5-Fluorouracil
(b) Bleomycin
(c) Etoposide
(d) Actinomycin D
57. Side effects of cisplatin include all of the following
EXCEPT:
(a) Nausea and vomiting
(b) Nephrotoxicity
(c) Blindness
(d) Ototoxicity
58. Most common side effect of 5-fluorouracil is:
(a) G.I. toxicity
(b) Bone marrow depression
(c) Cardiotoxicity
(d) Neurotoxicity
59. Which of the following is a common side effect of
cisplatin?
(a) Diarrhea
(b) Vomiting
(c) Pulmonary fibrosis
(d) Alopecia
60. The antimetabolite ‘X’ inhibits DNA polymerase and is
one of the most active drugs in the treatment of leukemia.
Although myelo-suppression is dose limiting, the drug
may also cause cerebellar dysfunction, including ataxia
and dysarthria. Which of the following can be ‘X’?
(a) Bleomycin
(b) Cytarabine
(c) Mercaptopurine
(d) Methotrexate
61. Which of the following antineoplastic drugs should not
be administered to a chronic alcoholic patient due to
risk of development of disulfiram like reaction?
(a) Dacarbazine
(b) Procarbazine
(c) Melphalan
(d) Hydroxyurea
62. Roopa Devi, a 65-year-old female with ovarian cancer is
being treated with cisplatin-based chemotherapy. All of
the following are used to limit the toxicity of cisplatin
except:
(a) N-acetylcysteine
(b) Slow rate of infusion
(c) Chloride diuresis
(d) Amifostine
63. Roopmati, A 56-year-old female with lymph-nodepositive
breast cancer was treated with systemic
chemotherapy. Four weeks later, she developed frequent
urination, suprapubic pain, dysuria, and hematuria.
Which of the following could have prevented this
patient’s condition?
(a) Folinic acid
(b) Mesna
(c) Dexrazoxane
(d) Amifostine
64. Sunder, a young male was diagnosed as suffering from
acute myeloid leukemia. He was started on induction
chemotherapy with doxorubicin based regiments.
Induction regimen was successful. Two months later,
he presents to OPD with swelling of both the feet
and breathlessness on climbing the stairs. He also
complains the he had to wake up many times because
of breathlessness. Which of the following is most likely
responsible for this patient’s symptoms?
(a) Restrictive cardiomyopathy
(b) Hypertrophic cardiomyopathy
(c) Dilated cardiomyopathy
(d) Pericardial fibrosis
65. Which of the following anticancer drugs can cross
blood brain barrier?
(DELHI-PG-2008)
(a) Cisplatin
(b) Nitrosourea
(c) Vincristine
(d) Vinblastine
66. Which of the following drugs produce significant
nephrotoxicity?
(DELHI-PG-2007)
(a) Cisplatin
(b) Carboplatin
(c) Vinblastine
(d) Vincristine
67. Folinic acid counteracts the toxicity of: (DPG 2002)
(a) Doxorubicin
(b) Methotrexate
(c) Cyclophosphamide
(d) Fluorouracil
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