Review of Pharmacology - 9E (2015)

Review of Pharmacology
Autacoids
65. True stagements regarding aspirin toxicity are:
(a) Tinnitus is an early symptom (PGI June, 2006)
(b) 10-30 g causes poisoning
(c) Hyperthermia, tachypnea are early complications
(d) Cause thrombocytopenic purpura
(e) Children can tolerate much higher dose than adults
66. COX pathway is inhibited by: (PGI June, 2002)
(a) Aspirin
(b) Indomethacin
(c) Betamethasone
(d) Calcitonin
(e) Diclofenac
67. Which of the following is/are cyclo-oxygenase
inhibitors: (AP 2003, PGI June, 2001)
(a) Aspirin
(b) Prednisolone
(c) Indomethacin
(d) Betamethasone
(e) Rofecoxib
68. A relatively newer agent ‘latanoprost’ is now being used.
Which of the following statements is true regarding this
agent?
(a) It is PGF 2α
derivative used in glaucoma
(b) It is selective α 1
blocker used in benign hy per trophy
of prostate
(c) It is a 5α reductase inhibitor used to reduce the size
of enlarged prostate gland
(d) It is a PGE 2
analogue used intravaginally for cervical
priming
69. All of the following are indications for eicosanoids or
their inhibitors except:
(a) Abortion
(b) Essential hypertension
(c) Patent ductus arteriosus
(d) Transposition of the great arteries
70. Which of the following drugs inhibit platelet cyclooxygenase
reversibly?
(a) Alprostadil
(b) Aspirin
(c) Ibuprofen
(d) Prednisolone
71. Which of the following is a component of slow reacting
substance of anaphylaxis (SRS-A)?
(a) LTC 4
(b) LTB 4
(c) Misoprostol
(d) Prostacyclin
72. Which of the following drugs reduces the activity of
phospholipase A 2
?
(a) Alprostadil
(b) Aspirin
(c) Ibuprofen
(d) Prednisolone
73. The chief advantage of ketorolac over aspirin is that the
former:
(a) Can be combined more safely with an opioid such as
codeine.
(b) Does not prolong bleeding time.
(c) Is available in a parenteral formulation that can be
used intramuscularly or intravenously.
(d) Is less likely to cause acute renal failure in patients
with pre-existing renal impairment.
74. Which of the following patient characteristics is a possible
reason for the use of celecoxib in the treatment of
arthritis?
(a) History of severe rash after treatment with a sulfonamide
antibiotic
(b) History of gout
(c) History of peptic ulcer disease
(d) History of type 2 DM
75. Irreversible inhibitor of cyclooxygenase is:
(a) Aspirin
(b) Phenylbutazone
(c) Indomethacin
(d) Piroxicam
76. Prostaglandin E 2
analogs can be used for all of the following
conditions except:
(a) Treatment of patent ductus arteriosus
(b) Treatment of bronchial asthma
(c) Cervical priming
(d) Treatment of NSAID induced peptic ulcer
77. Aspirin in low doses produces long lasting inhibition
of platelet cyclooxygenase because:
(a) Platelet contain low quantity of COX
(b) Platelets cannot synthesize fresh COX molecules
(c) Platelets bind aspirin with high affinity
(d) Platelet COX is inducible
78. Zafirlukast acts by blocking the action of:
(a) Prostacyclin
(b) Platelet activating factor
(c) Leukotriene B 4
(d) Leukotriene C 4
/D 4
79. NSAID lacking anti-inflammatory action is:
(a) Paracetamol
(b) Ibuprofen
(c) Diclofenac sodium
(d) Celecoxib
80. True statement about cyclooxygenase –2 is:
(a) It is not inhibited by indomethacin
(b) It is inducible
(c) It generates cytoprotective prostaglandins in gastric
mucosa
(d) It is found only in fetal tissues
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