Review of Pharmacology - 9E (2015)

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Review of Pharmacology 85. Thyroxine is used in the treatment of which thyroid cancer: (a) Medullary (b) Radiation induced (c) Anaplastic (d) Papillary 86. Drug of choice for bleeding oesophageal varices is: (a) Ethanolamine oleate (b) Octreotide (c) Propanolol (d) Phytonadione 87. All of the following reduce T 4 absorption except: (a) Metformin (b) Iron salts (c) Raloxifene (d) Colsevelam Endocrinology 288 https://kat.cr/user/Blink99/
Endocrinology Explanations 1. Ans. (b) Hypoglycemia (Ref: Goodman and Gilman 12/e p1116-1117) Growth hormone therapy commonly leads to hyperglycemia (not hypoglycaemia) 2. Ans. (c) Bromocriptine (Ref: KDT 6/e p236) It is an ergot alkaloid and is a dopamine agonist. Dopamine acts as prolactin inhibiting hormone in the brain. Agonism of dopamine receptors by bromocriptine is responsible for its use in hyperprolactinemia. 3. Ans. (b) Bromocriptine (Ref.: KK Sharma 2/e p550) Bromocriptine is a D 2 agonist and is useful in hyperprolactinemia by its action to inhibit the release of prolactin. 4. Ans. (d) Glioma (Ref: Katzung 11/e p650, 1081-1082) • Octreotide is a long acting somatostatin analog. It can be used: • To decrease secretory diarrhea and other symptoms of carcinoid syndrome and VIPoma. • For the treatment of diarrhea due to vagotomy, short bowel syndrome and AIDS. • For treatment and prophylaxis of acute pancreatitis. • For the management of acromegaly • For the treatment of islet cell tumors • For controlling acute bleeding due to esophageal varices 5. Ans. (a) It is effective orally (Ref: Katzung 9/e p1048, KDT 6/e p35) • Octreotide is the long acting and more potent synthetic analog of somatostatin. • It can be administered by i.v., s.c. or i.m. routes. It is not effective orally. • It can be used for –– Acromegaly –– Secretory diarrhea associated with carcinoids and AIDS –– Islet cell tumors –– Esophageal varices (seen in cases of portal hypertension). 6. Ans. (b) It is longer acting than somatostatin (Ref: KDT 6/e p235) For details, see text 7. Ans. (d) Nafarelin (Ref: KDT 6/e p239) Nafarelin is a GnRH agonist. It has no role in acromegaly. 8. Ans. (a) Agonism at D 2 receptors (Ref: KDT 6/e p236) 9. Ans. (b) Immediately reduces gonadotropin secretion (Ref: KDT 6/e p239) • GnRH agonists like leuprolide, goserelin and nafarelin etc. are used by parenteral route. Continuous administration of these agents decreases gonadotropin secretion whereas pulsatile administration increases the secretion. When used continuously even then first few doses cause increased secretion of gonadotropins (LH and FSH) leading to flare up reaction in prostatic carcinoma. • GnRH antagonists like cetrorelix and ganirelix are also used by parenteral route but these drugs immediately reduce gonadotropin secretion. 10. Ans. (a) Bromocriptine (Ref: KDT 6/e p236) Hyperprolactinemia is caused by D 2 blockers. All the drugs listed are D 2 blockers except bromocriptine which is a D 2 receptor agonist. It is used in the treatment of hyperprolactinemia. 11. Ans. (a) Bromocriptine (Ref: KDT 6/e p236) • Symptoms of the patient (amenorrhea, galactorrhea and infertility) points towards the diagnosis of hyperprolactinemia. • Bromocriptine is a D 2 receptor agonist that can be used in the treatment of hyperprolactinemia (dopamine acts as prolacting release inhibiting hormone in the hypothalamus). • Psychosis occurs due to excessive stimulation of D 2 receptors (D 2 blockers are used as typical antipsychotic drugs) and bromocriptine can precipitate the symptoms in predisposed patients. General Endocrinology Pharmacology 289 https://kat.cr/user/Blink99/
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Review of Pharmacology Ninth Editio
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Dedicated to My parents, wife Prave
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Preface to the Ninth Edition We wan
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Acknowledgments When emotions are p
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References • Harrison’s Princip
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Contents 1. History of Pharmacology
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CHAPTER 1 History of pharmacology S
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CHAPTER 2 General Pharmacology Phar
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General Pharmacology Note: It is si
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General Pharmacology Drug metaboliz
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General Pharmacology Order of kinet
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General Pharmacology Therapeutic Dr
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General Pharmacology Fig. 2.4: G-pr
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General Pharmacology sigmoid shaped
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General Pharmacology Phase 1: Here,
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General Pharmacology 5. Essential m
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General Pharmacology (b) Bioavailab
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General Pharmacology (c) Are highly
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General Pharmacology (c) Strong aci
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General Pharmacology (a) 50 mg/hour
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General Pharmacology 140. Phamacoge
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General Pharmacology (c) Piroxicam
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206. Which of the following drugs s
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General Pharmacology 29. In which t
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General Pharmacology Explanations 1
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General Pharmacology • Other fact
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General Pharmacology -- Suppose, 10
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General Pharmacology 77. Ans. (a) W
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= 40 L × 4 mg/L = 160 mg Clearance
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General Pharmacology 126. Ans. (c)
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General Pharmacology 154. Ans. (d)
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General Pharmacology Intolerance is
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General Pharmacology 6. Ans. (b) b
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CHAPTER 3 Autonomic Nervous System
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Autonomic Nervous System Functions
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Autonomic Nervous System • Carbac
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Autonomic Nervous System used for g
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Autonomic Nervous System -- Central
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Autonomic Nervous System • Theref
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Autonomic Nervous System • Eye: S
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Autonomic Nervous System • Dopami
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Autonomic Nervous System • Phenox
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Autonomic Nervous System Lipid Inso
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Autonomic Nervous System Drug of Ch
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Multiple Choice Questions Autonomic
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Autonomic Nervous System (c) Organo
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(c) Physostigmime (d) Hyoscine hydr
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Autonomic Nervous System (c) Tropic
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132. A drug that blocks the uptake
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165. Clonidine is used for: (Kolkat
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as an effective substitute which do
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Autonomic Nervous System 13. Which
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Autonomic Nervous System (c) Increa
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Autonomic Nervous System 9. Ans. (a
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Autonomic Nervous System 39. Ans. (
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Autonomic Nervous System - Temazepa
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Autonomic Nervous System 103. Ans.
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Autonomic Nervous System have no ef
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Autonomic Nervous System 23. Ans. (
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CHAPTER 4 Autacoids These are the s
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Autacoids All second generation ant
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Autacoids v v v v v Calcium channel
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Autacoids nary bypass. It can also
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Autacoids to presence of sulfur con
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Autacoids Rheumatoid Arthritis Rheu
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Autacoids It is a monoclonal antibo
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Autacoids Drug of choice Condition
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15. Anti-vertigo drug which modulat
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49. Sumatriptan is: (DPG 1999, TN 2
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81. All of the following effects ar
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114. Which prostaglandin helps in c
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Autacoids 148. Which of the followi
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Autacoids 30. A 15 year old boy was
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Autacoids 16. Ans. (b) Dangerous ve
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Autacoids 56. Ans. (c) Cyclooxygena
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Autacoids 85. Ans. (b) Aspirin supp
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Autacoids 125. Ans. (b) Indomethaci
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Autacoids 13. Ans. (a) Naproxen (Re
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CHAPTER 5 Cardiovascular System CON
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Cardiovascular System In atrial fib
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Cardiovascular System Treatment of
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Cardiovascular System should be use
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Cardiovascular System tive α 1 blo
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Cardiovascular System nifedipine an
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Cardiovascular System Treatment of
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Cardiovascular System ANGINA PECTOR
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Cardiovascular System BETA BLOCKERS
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Cardiovascular System The action po
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Cardiovascular System depolarized c
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Cardiovascular System • Digoxin i
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Cardiovascular System Contd... •
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Cardiovascular System DRUG OF CHOIC
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15. Digoxin toxicity is aggravated
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(c) Treat digoxin toxicity (d) Rapi
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(c) Decreases sodium and increases
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Cardiovascular System 113. All of t
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146. Which of the following drugs i
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Cardiovascular System 180. Characte
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213. In a patient with hypertriglyc
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247. ACE inhibitors cause: (PGI Dec
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Cardiovascular System 16. Dialysis
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Cardiovascular System 53. Which of
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• Nesiritide is a recombinant BNP
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Cardiovascular System 43. Ans. (d)
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Cardiovascular System 81. Ans. (a)
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Cardiovascular System -- Hypertensi
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Cardiovascular System Cyanide has v
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Cardiovascular System 13. Ans (b) P
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CHAPTER 6 Kidney Diuretics Diuretic
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Kidney Uses Main use of loop diuret
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Kidney • Amiloride is more potent
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Kidney Amiloride It is the agent of
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Kidney Multiple Choice Questions di
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30. Which of the following statemen
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66. Advantage of desmopressin over
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Kidney Explanations 1. Ans. (b) Hyp
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16. Ans. (b) Bumetanide (Ref: KDT 6
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Kidney 55. Ans (d) V 4 : Central Ne
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CHAPTER 7 Endocrinology Hormones ar
Page 249 and 250: Endocrinology Prolactin It causes g
Page 251 and 252: Endocrinology • In the liver and
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Page 255 and 256: Endocrinology Drug interactions •
Page 257 and 258: Endocrinology Lactic acidosis (more
Page 259 and 260: Endocrinology 3. amylin analogs Pra
Page 261 and 262: Endocrinology Important Points Maxi
Page 263 and 264: Endocrinology • Steroids with sel
Page 265 and 266: Endocrinology • Vitamin D 2 is er
Page 267 and 268: Endocrinology Denosumab Osteoclasts
Page 269 and 270: Endocrinology • SERMs are targete
Page 271 and 272: Endocrinology Contd... • Uliprist
Page 273 and 274: Endocrinology only pills. Chances o
Page 275 and 276: Endocrinology Pharmacokinetics Test
Page 277 and 278: Endocrinology Ergot Derivatives Erg
Page 279 and 280: Endocrinology Contd... • Hyperpro
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Page 283 and 284: (c) Glucose (d) Starch 47. True abo
Page 285 and 286: (c) Na + exit/K + entry (d) K + ent
Page 287 and 288: Endocrinology 113. Which of the fol
Page 289 and 290: 147. Bisphosphonates act by: (AI 20
Page 291 and 292: 180. Women receiving estrogen thera
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Page 297 and 298: Endocrinology 32. Drug used to cont
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Page 303 and 304: Endocrinology 24. Ans. (c) Propylth
Page 305 and 306: Endocrinology • When this drug is
Page 307 and 308: Endocrinology Hypoglycemia is cause
Page 309 and 310: Endocrinology Drugs causing Addison
Page 311 and 312: Endocrinology Raloxifene is a selec
Page 313 and 314: Endocrinology • Enzyme inducers l
Page 315 and 316: Endocrinology 197. Ans. (b) Blocks
Page 317 and 318: Endocrinology A spider angioma (als
Page 319 and 320: Endocrinology 4. Ans (c) Glaucoma (
Page 321 and 322: Endocrinology 70. Ans. (c) Mifepris
Page 323 and 324: NOTES _____________________________
Page 325 and 326: CHAPTER 8 Central Nervous System Se
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Page 333 and 334: Central Nervous System Wilson’s D
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Page 337 and 338: Central Nervous System • Lamotrig
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Page 343 and 344: Central Nervous System bulimia, pre
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Central Nervous System Actions •
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Central Nervous System Contd... •
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(c) Alkalization of the urine will
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Central Nervous System (c) Ketamine
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79. Drug of choice for myoclonic ep
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(c) Phenytoin (d) Valproic acid 112
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146. Which of the following antipsy
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(c) Regular measurements of blood c
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210. A patient Rajnish having depre
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242. Drug useful in malignant hyper
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279. Preferred drug for alcohol wit
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314. Morphine can administered by a
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(c) Analgesia (d) Mydriasis 348. Di
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17. Antiparkinson drug known to cau
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53. Which drug is the most useful i
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Central Nervous System 15. Ans. (c)
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Central Nervous System 39. Ans. (b)
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67. Ans. (a) Phenytoin (Ref: Katzun
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97. Ans. (a) Hepatitis (Ref: KDT 6/
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Central Nervous System 145. Ans (c)
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Central Nervous System 159. Ans. (d
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Central Nervous System 187. Ans. (b
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Central Nervous System 212. Ans. (a
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Central Nervous System 258. Ans. (a
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Central Nervous System 303. Ans. (c
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Central Nervous System 326. Ans. (c
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Central Nervous System 60. Ans. (a)
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CHAPTER 9 Anaesthesia Local Anaesth
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Anaesthesia trigeminal nerve, cervi
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Anaesthesia Centrally Acting Muscle
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Anaesthesia • These drugs release
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Anaesthesia Anaesthetic MAC (% atm)
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Anaesthesia Methemoglobinemia and l
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Anaesthesia Chloroform • It is a
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Anaesthesia Contd... • It does no
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Anaesthesia Anaesthetic agents of c
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Anaesthesia Multiple Choice Questio
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33. Post dural (Spinal) puncture he
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(b) Dantrolene (c) Succinylcholine
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103. Which of the following drugs a
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Anaesthesia 138. Thiopental sodium
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Anaesthesia Explanations 1. Ans (c)
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Anaesthesia 20. Ans. (d) Seizures a
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Anaesthesia 49. Ans. (b) Meprobamat
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Anaesthesia • The patient underwe
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Anaesthesia 91. Ans. (b) Sevofluran
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Anaesthesia • In pheochromocytoma
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CHAPTER 10 Hematology HAEMATINICS T
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Hematology • Deficiency of folic
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Hematology • Main drugs acting as
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Hematology 1. Oral Anticoagulants
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Hematology • Bioavailability of u
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Hematology • Rodenticides contain
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Hematology Condition • Anemia Dru
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(c) Erythropoietin (d) Filgrastim (
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Hematology 46. Tirofiban is a: (RJ
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80. The anticoagulant of choice in
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6. Mechanism of action of clopidogr
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Hematology Explanations 1. Ans. (c)
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Hematology 17. Ans. (d) Oprelvekin
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Hematology 51. Ans. (a) Dabigatran:
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Hematology 71. Ans. (c) Warfarin (R
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Hematology 106. Ans. (c) Streptokin
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CHAPTER 11 Respiratory System Cough
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Respiratory System fast acting also
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Respiratory System LT receptor anta
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Respiratory System Condition • Br
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17. The most prominent and dose rel
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Respiratory System 52. In theophyll
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Respiratory System Explanations 1.
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Respiratory System • Inhalational
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CHAPTER 12 Gastrointestinal Tract P
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Gastrointestinal Tract Contd... --
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Gastrointestinal Tract Anti Emetic
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Gastrointestinal Tract Domperidone
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Gastrointestinal Tract Oral Rehydra
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Gastrointestinal Tract Condition
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(c) Misoprostol (d) Omeprazole 15.
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49. The most effective antiemetic f
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Gastrointestinal Tract recent Quest
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Gastrointestinal Tract Explanations
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Gastrointestinal Tract 30. Ans. (b)
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Gastrointestinal Tract 1. EarlyPhas
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Gastrointestinal Tract 17. Ans. (c)
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CHAPTER 13 Chemotherapy A: General
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Chemotherapy A: General Considerati
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contd... Drugs Binds to Mechanism o
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Contd... Chemotherapy A: General Co
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Clinical Uses Chemotherapy A: Gener
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Important Points About Antimicrobia
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128. Ans. (b) Trovafloxacin (Goodma
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CHAPTER 14 Chemotherapy B: Antimicr
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Chemotherapy B: Antimicrobials for
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Clofazimine It is a dye with lepros
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Foscarnet It is not an antimetaboli
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Human Immunodeficiency Virus (HIV)
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16. Bactericidal drugs in ATT are:
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50. Ethambutol should be used very
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120. Regarding ritonavir use in AID
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ACTs). All of the following combina
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ecent Questions asked by National B
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Explanations Chemotherapy B: Antimi
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25. Ans. (b) Ethionamide (Ref: KDT
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CHAPTER 15 Chemotherapy C: Antineop
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Chemotherapy C: Antineoplastic Drug
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4-5 years). Another distinguishing
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GnRH Antagonists Cetrorelix, ganire
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This drug was used in 1960s as a se
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Multiple Choice Questions Chemother
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37. Which of the following statemen
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CHAPTER 16 Immunomodulators IMMUNOS
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Immunomodulators 9. Antibodies Poly
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Immunomodulators Examples of each t
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Immunomodulators Clinical Diagnosis
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(b) Podophylline (c) Interferon (d)
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(c) Cytarabine (d) Cycloserine 51.
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Immunomodulators Explanations 1. An
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Immunomodulators 14. Ans. (a) Syste
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Immunomodulators 33. Ans. (a) Gluco
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CHAPTER 17 Other Topics and Adverse
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Other Topics and Adverse Effects Co
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17. A 2 years old child without fev
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54. Isotretinoin is: (PGI June, 200
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Other Topics and Adverse Effects (c
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects 39
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Other Topics and Adverse Effects 55
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Other Topics and Adverse Effects Dr
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CHAPTER 18 Drugs of Choice Drug of
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Drugs of Choice Contd... Hypertensi
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Contd... VRSA LINEZOLID/STREPTOGRAM
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CHAPTER 19 New Drugs 1. Abatacept:
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New Drugs 52. Canakinumab: A human
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New Drugs 100. Ecallantide: A plasm
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New Drugs 153. Laronidase: Recombin
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New Drugs 204. Peginesatide: A pept
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New Drugs been approved for the tre
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New Drugs and B lymphocytes after e
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New Drugs prevents nausea and vomit
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CHAPTER 20 Recent Topics TRICYCLIC
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Recent Topics 2. Drugs 5-HT 2 recep
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Recent Topics Arginine NOS NO + Cit
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Recent Topics Contd... Drug Tetracy
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Recent Topics -- If the patient has
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CHAPTER 21 Latest Papers AIIMS Nove
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Latest Papers explanations 1. Ans.
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• Clindamycin and erythromycin ar
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Latest Papers AIIMS May 2014 1. Whi
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Latest Papers explanations 1. Ans.
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13. Ans. a. Hypokalemia (Ref: Harri
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NOTES _____________________________
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Image Based Questions https://kat.c
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Image Based Questions 1. The result
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5. A new antiarrhythmic drug is fou
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10. Amarnath, a 58 year old busines
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14. A 72-year-old male, Hemraj was
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(rapid vs slow induction of anesthe
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Review of Pharmacology - 9E (2015)

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