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Review of Pharmacology - 9E (2015)

Review

Review of Pharmacology 26. Ans. (d) Selegiline (Ref: KDT 7/e p430) 27. Ans. (b) Amoxapine (Ref: KDT 7/e p460) 28. Ans. (d) Buspirone (Ref: KDT 7/e p404) 29. Ans. (b) Ketamine (Ref: KDT 7/e p384) 30. Ans. (d) Nalmefene (Ref: KDT 7/e p484) 31. Ans. (c) Nephrotoxicity (Ref: KDT 7/e p417) 32. Ans. (d) It is longer acting and causes milder withdrawal symptoms (Ref: KDT 7/e p476) 33. Ans. (b) Flumazenil (Ref: KDT 7/e p408) 34. Ans. (c) Methyl alcohol (Ref: KDT 7/e p395) 35. Ans. (c) Gabapentin (Ref: KDT 7/e p419) 36. Ans. (d) Left ventricular failure (Ref: KDT 7/e p471) 37. Ans. (a) Sertraline (Ref: KDT 7/e p464) 38. Ans. (a) Sodium valproate (Ref: CMDT 2014/ p937) 39. Ans. (c) Flumazenil (Ref: KDT 7/e p393-394) Central Nervous System 40. Ans. (c) Bromocriptine (Ref: KDT 7/e p430) 41. Ans. (d) Fluphenazine (Ref: KDT 7/e p439) 42. Ans. (c) Pentazocine (Ref: KDT 7/e p481) 43. Ans. (b) Lorazepam (Ref: KDT 7/e p424) 44. Ans. (b) Valproate (Ref: CMDT 2014/ p938) 45. Ans. (c) Increase the release of neurotransmitters (Ref: KDT 7/e p419) 46. Ans. (d) Continue with Phenytoin and add Tab. Folic acid and during the last 2 weeks of pregnancy give oral Vitamin K too (Ref: KDT 7/e p422) 47. Ans. (c) Lithium (Ref: KDT 7/e p450) 48. Ans. (b) Acute dystonia (Ref: KDT 7/e p444) 49. Ans. (b) Labile blood pressure (Ref: KDT 7/e p444) 50. Ans. (d) Dilated pupils (Ref: KDT 7/e p479) 51. Ans. (d) Phenobarbitone (Ref: KDT 7/e p412) 52. Ans. (c) Is secreted by pituitary (Ref: KDT 7/e p409) 53. Ans. (c) Promethazine (Ref: KDT 7/e p444) 54. Ans. (b) Benzodiazepines (Ref: KDT 7/e p398) 55. Ans. (d) Aldehyde dehydrogenase (Ref: KDT 7/e p394) 56. Ans. (b) Anti psychotics (Ref: KDT 7/e p436) 57. Ans. (d) Flumazenil (Ref: KDT 7/e p408) 58. Ans. (a) Lithium (Ref: KDT 7/e p450) 394 59. Ans. (a) Formic acid (Ref: KDT 7/e p395) https://kat.cr/user/Blink99/

Central Nervous System 60. Ans. (a) Metoclopramide (Ref: KDT 7/e p666) 61. Ans. (d) Benzhexol (Ref: KDT 7/e p433) 62. Ans. (d) Pentazocine (Ref: KDT 7/e p481) 63. Ans. (d) Chlorpromazine (Ref: KDT 7/e p454) 64. Ans. (d) Fluoxetine (Ref: KDT 7/e p464) 65. Ans. (a) Lithium (Ref: KDT 7/e p450) 66. Ans. (a) Vigabatrin (Ref: KDT 7/e p421) 67. Ans. (d) Haloperidol (Ref: KDT 7/e p465) 68. Ans. (b) Diphenoxylate (Ref: KDT 7/e p686) 69. Ans. (c) Lorazepam (Ref: KDT 7/e p405) 70. Ans. (a) Valproic acid (Ref: KDT 7/e p421) 71. Ans. (a) Olanzapine (Ref: KDT 7/e p446) 72. Ans. (b) Lithium (Ref: KDT 7/e p450) 73. Ans. (c) Ethylene glycol poisoning (Ref: KDT 7/e p396) General Central Nervous Pharmacology System 395 https://kat.cr/user/Blink99/

  • Page 1 and 2:

    Review of Pharmacology Ninth Editio

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    Dedicated to My parents, wife Prave

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    Preface to the Ninth Edition We wan

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    Acknowledgments When emotions are p

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    References • Harrison’s Princip

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    Contents 1. History of Pharmacology

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    CHAPTER 1 History of pharmacology S

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    CHAPTER 2 General Pharmacology Phar

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    General Pharmacology Note: It is si

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    General Pharmacology Drug metaboliz

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    General Pharmacology Order of kinet

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    General Pharmacology Therapeutic Dr

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    General Pharmacology Fig. 2.4: G-pr

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    General Pharmacology sigmoid shaped

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    General Pharmacology Phase 1: Here,

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    General Pharmacology 5. Essential m

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    General Pharmacology (b) Bioavailab

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    General Pharmacology (c) Are highly

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    General Pharmacology (c) Strong aci

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    General Pharmacology (a) 50 mg/hour

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    General Pharmacology 140. Phamacoge

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    General Pharmacology (c) Piroxicam

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    206. Which of the following drugs s

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    General Pharmacology 29. In which t

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    General Pharmacology Explanations 1

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    General Pharmacology • Other fact

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    General Pharmacology -- Suppose, 10

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    General Pharmacology 77. Ans. (a) W

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    = 40 L × 4 mg/L = 160 mg Clearance

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    General Pharmacology 126. Ans. (c)

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    General Pharmacology 154. Ans. (d)

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    General Pharmacology Intolerance is

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    General Pharmacology 6. Ans. (b) b

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    CHAPTER 3 Autonomic Nervous System

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    Autonomic Nervous System Functions

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    Autonomic Nervous System • Carbac

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    Autonomic Nervous System used for g

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    Autonomic Nervous System -- Central

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    Autonomic Nervous System • Theref

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    Autonomic Nervous System • Eye: S

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    Autonomic Nervous System • Dopami

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    Autonomic Nervous System • Phenox

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    Autonomic Nervous System Lipid Inso

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    Autonomic Nervous System Drug of Ch

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    Multiple Choice Questions Autonomic

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    Autonomic Nervous System (c) Organo

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    (c) Physostigmime (d) Hyoscine hydr

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    Autonomic Nervous System (c) Tropic

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    132. A drug that blocks the uptake

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    165. Clonidine is used for: (Kolkat

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    as an effective substitute which do

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    Autonomic Nervous System 13. Which

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    Autonomic Nervous System (c) Increa

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    Autonomic Nervous System 9. Ans. (a

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    Autonomic Nervous System 39. Ans. (

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    Autonomic Nervous System - Temazepa

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    Autonomic Nervous System 103. Ans.

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    Autonomic Nervous System have no ef

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    Autonomic Nervous System 166. Ans.

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    Autonomic Nervous System 194. Ans.

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    Autonomic Nervous System 23. Ans. (

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    CHAPTER 4 Autacoids These are the s

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    Autacoids All second generation ant

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    Autacoids v v v v v Calcium channel

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    Autacoids nary bypass. It can also

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    Autacoids to presence of sulfur con

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    Autacoids Rheumatoid Arthritis Rheu

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    Autacoids It is a monoclonal antibo

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    Autacoids Drug of choice Condition

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    15. Anti-vertigo drug which modulat

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    49. Sumatriptan is: (DPG 1999, TN 2

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    81. All of the following effects ar

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    114. Which prostaglandin helps in c

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    Autacoids 148. Which of the followi

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    Autacoids 30. A 15 year old boy was

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    Autacoids 16. Ans. (b) Dangerous ve

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    Autacoids 56. Ans. (c) Cyclooxygena

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    Autacoids 85. Ans. (b) Aspirin supp

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    Autacoids 125. Ans. (b) Indomethaci

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    Autacoids 13. Ans. (a) Naproxen (Re

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    CHAPTER 5 Cardiovascular System CON

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    Cardiovascular System In atrial fib

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    Cardiovascular System Treatment of

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    Cardiovascular System should be use

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    Cardiovascular System tive α 1 blo

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    Cardiovascular System nifedipine an

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    Cardiovascular System Treatment of

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    Cardiovascular System ANGINA PECTOR

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    Cardiovascular System BETA BLOCKERS

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    Cardiovascular System The action po

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    Cardiovascular System depolarized c

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    Cardiovascular System • Digoxin i

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    Cardiovascular System Contd... •

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    Cardiovascular System DRUG OF CHOIC

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    15. Digoxin toxicity is aggravated

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    (c) Treat digoxin toxicity (d) Rapi

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    (c) Decreases sodium and increases

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    Cardiovascular System 113. All of t

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    146. Which of the following drugs i

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    Cardiovascular System 180. Characte

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    213. In a patient with hypertriglyc

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    247. ACE inhibitors cause: (PGI Dec

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    Cardiovascular System 16. Dialysis

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    Cardiovascular System 53. Which of

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    • Nesiritide is a recombinant BNP

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    Cardiovascular System 43. Ans. (d)

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    Cardiovascular System 81. Ans. (a)

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    Cardiovascular System -- Hypertensi

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    Cardiovascular System Cyanide has v

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    Cardiovascular System 178. Ans. (a)

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    Cardiovascular System 217. Ans. (a)

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    Cardiovascular System 237. Ans. (a)

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    Cardiovascular System 13. Ans (b) P

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    CHAPTER 6 Kidney Diuretics Diuretic

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    Kidney Uses Main use of loop diuret

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    Kidney • Amiloride is more potent

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    Kidney Amiloride It is the agent of

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    Kidney Multiple Choice Questions di

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    30. Which of the following statemen

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    66. Advantage of desmopressin over

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    Kidney Explanations 1. Ans. (b) Hyp

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    16. Ans. (b) Bumetanide (Ref: KDT 6

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    Kidney 55. Ans (d) V 4 : Central Ne

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    CHAPTER 7 Endocrinology Hormones ar

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    Endocrinology Prolactin It causes g

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    Endocrinology • In the liver and

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    Endocrinology I 131 can be used for

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    Endocrinology Drug interactions •

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    Endocrinology Lactic acidosis (more

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    Endocrinology 3. amylin analogs Pra

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    Endocrinology Important Points Maxi

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    Endocrinology • Steroids with sel

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    Endocrinology • Vitamin D 2 is er

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    Endocrinology Denosumab Osteoclasts

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    Endocrinology • SERMs are targete

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    Endocrinology Contd... • Uliprist

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    Endocrinology only pills. Chances o

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    Endocrinology Pharmacokinetics Test

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    Endocrinology Ergot Derivatives Erg

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    Endocrinology Contd... • Hyperpro

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    completion of therapy, the patient

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    (c) Glucose (d) Starch 47. True abo

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    (c) Na + exit/K + entry (d) K + ent

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    Endocrinology 113. Which of the fol

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    147. Bisphosphonates act by: (AI 20

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    180. Women receiving estrogen thera

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    (c) Clomiphene (d) Mifepristone (RU

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    246. Mechanism of Calcitriol is: (R

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    Endocrinology 32. Drug used to cont

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    (b) Glimepiride (c) Repaglinide (d)

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    Endocrinology Explanations 1. Ans.

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    Endocrinology 24. Ans. (c) Propylth

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    Endocrinology • When this drug is

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    Endocrinology Hypoglycemia is cause

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    Endocrinology Drugs causing Addison

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    Endocrinology Raloxifene is a selec

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    Endocrinology • Enzyme inducers l

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    Endocrinology 197. Ans. (b) Blocks

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    Endocrinology A spider angioma (als

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    Endocrinology 4. Ans (c) Glaucoma (

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    Endocrinology 70. Ans. (c) Mifepris

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    NOTES _____________________________

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    CHAPTER 8 Central Nervous System Se

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    Central Nervous System It is admini

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    Central Nervous System • Abnormal

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    Central Nervous System useful in AD

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    Central Nervous System Wilson’s D

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    Central Nervous System Important Dr

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    Central Nervous System • Lamotrig

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    Central Nervous System play a role

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    Central Nervous System According to

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    Central Nervous System bulimia, pre

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    Central Nervous System Anti Manic D

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    Central Nervous System dependence,

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    Central Nervous System increase hea

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    Central Nervous System Actions •

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    Central Nervous System Contd... •

  • Page 355 and 356: (c) Alkalization of the urine will
  • Page 357 and 358: Central Nervous System (c) Ketamine
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  • Page 361 and 362: (c) Phenytoin (d) Valproic acid 112
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  • Page 365 and 366: (c) Regular measurements of blood c
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  • Page 371 and 372: 279. Preferred drug for alcohol wit
  • Page 373 and 374: 314. Morphine can administered by a
  • Page 375 and 376: (c) Analgesia (d) Mydriasis 348. Di
  • Page 377 and 378: 17. Antiparkinson drug known to cau
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  • Page 381 and 382: Central Nervous System 15. Ans. (c)
  • Page 383 and 384: Central Nervous System 39. Ans. (b)
  • Page 385 and 386: 67. Ans. (a) Phenytoin (Ref: Katzun
  • Page 387 and 388: 97. Ans. (a) Hepatitis (Ref: KDT 6/
  • Page 389 and 390: Central Nervous System 145. Ans (c)
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  • Page 393 and 394: Central Nervous System 187. Ans. (b
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  • Page 397 and 398: Central Nervous System 258. Ans. (a
  • Page 399 and 400: Central Nervous System 286. Ans. (b
  • Page 401 and 402: Central Nervous System 303. Ans. (c
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  • Page 405: Central Nervous System 366. Ans. (b
  • Page 409 and 410: CHAPTER 9 Anaesthesia Local Anaesth
  • Page 411 and 412: Anaesthesia trigeminal nerve, cervi
  • Page 413 and 414: Anaesthesia Centrally Acting Muscle
  • Page 415 and 416: Anaesthesia • These drugs release
  • Page 417 and 418: Anaesthesia Anaesthetic MAC (% atm)
  • Page 419 and 420: Anaesthesia Methemoglobinemia and l
  • Page 421 and 422: Anaesthesia Chloroform • It is a
  • Page 423 and 424: Anaesthesia Contd... • It does no
  • Page 425 and 426: Anaesthesia Anaesthetic agents of c
  • Page 427 and 428: Anaesthesia Multiple Choice Questio
  • Page 429 and 430: 33. Post dural (Spinal) puncture he
  • Page 431 and 432: (b) Dantrolene (c) Succinylcholine
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  • Page 435 and 436: Anaesthesia 138. Thiopental sodium
  • Page 437 and 438: Anaesthesia Explanations 1. Ans (c)
  • Page 439 and 440: Anaesthesia 20. Ans. (d) Seizures a
  • Page 441 and 442: Anaesthesia 49. Ans. (b) Meprobamat
  • Page 443 and 444: Anaesthesia • The patient underwe
  • Page 445 and 446: Anaesthesia 91. Ans. (b) Sevofluran
  • Page 447 and 448: Anaesthesia • In pheochromocytoma
  • Page 449 and 450: CHAPTER 10 Hematology HAEMATINICS T
  • Page 451 and 452: Hematology • Deficiency of folic
  • Page 453 and 454: Hematology • Main drugs acting as
  • Page 455 and 456: Hematology 1. Oral Anticoagulants
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    Hematology • Bioavailability of u

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    Hematology • Rodenticides contain

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    Hematology Condition • Anemia Dru

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    (c) Erythropoietin (d) Filgrastim (

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    Hematology 46. Tirofiban is a: (RJ

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    80. The anticoagulant of choice in

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    6. Mechanism of action of clopidogr

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    Hematology Explanations 1. Ans. (c)

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    Hematology 17. Ans. (d) Oprelvekin

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    Hematology 51. Ans. (a) Dabigatran:

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    Hematology 71. Ans. (c) Warfarin (R

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    Hematology 106. Ans. (c) Streptokin

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    CHAPTER 11 Respiratory System Cough

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    Respiratory System fast acting also

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    Respiratory System LT receptor anta

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    Respiratory System Condition • Br

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    17. The most prominent and dose rel

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    Respiratory System 52. In theophyll

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    Respiratory System Explanations 1.

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    Respiratory System • Inhalational

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    CHAPTER 12 Gastrointestinal Tract P

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    Gastrointestinal Tract Contd... --

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    Gastrointestinal Tract Anti Emetic

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    Gastrointestinal Tract Domperidone

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    Gastrointestinal Tract Oral Rehydra

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    Gastrointestinal Tract Condition

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    (c) Misoprostol (d) Omeprazole 15.

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    49. The most effective antiemetic f

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    Gastrointestinal Tract recent Quest

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    Gastrointestinal Tract Explanations

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    Gastrointestinal Tract 30. Ans. (b)

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    Gastrointestinal Tract 1. EarlyPhas

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    Gastrointestinal Tract 17. Ans. (c)

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    CHAPTER 13 Chemotherapy A: General

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    Chemotherapy A: General Considerati

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    contd... Drugs Binds to Mechanism o

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Contd... Chemotherapy A: General Co

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    Chemotherapy A: General Considerati

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    Clinical Uses Chemotherapy A: Gener

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Important Points About Antimicrobia

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    128. Ans. (b) Trovafloxacin (Goodma

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    Chemotherapy A: General Considerati

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    CHAPTER 14 Chemotherapy B: Antimicr

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    Chemotherapy B: Antimicrobials for

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    Clofazimine It is a dye with lepros

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    Chemotherapy B: Antimicrobials for

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    Foscarnet It is not an antimetaboli

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    Human Immunodeficiency Virus (HIV)

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

  • Page 607 and 608:

    Chemotherapy B: Antimicrobials for

  • Page 609 and 610:

    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

  • Page 613 and 614:

    Chemotherapy B: Antimicrobials for

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    16. Bactericidal drugs in ATT are:

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    50. Ethambutol should be used very

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    Chemotherapy B: Antimicrobials for

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    120. Regarding ritonavir use in AID

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    ACTs). All of the following combina

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    Chemotherapy B: Antimicrobials for

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    ecent Questions asked by National B

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    Chemotherapy B: Antimicrobials for

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    Explanations Chemotherapy B: Antimi

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    25. Ans. (b) Ethionamide (Ref: KDT

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    Chemotherapy B: Antimicrobials for

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    CHAPTER 15 Chemotherapy C: Antineop

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    4-5 years). Another distinguishing

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    Chemotherapy C: Antineoplastic Drug

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    GnRH Antagonists Cetrorelix, ganire

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    This drug was used in 1960s as a se

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    Chemotherapy C: Antineoplastic Drug

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    Multiple Choice Questions Chemother

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    37. Which of the following statemen

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    Chemotherapy C: Antineoplastic Drug

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    CHAPTER 16 Immunomodulators IMMUNOS

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    Immunomodulators 9. Antibodies Poly

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    Immunomodulators Examples of each t

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    Immunomodulators Clinical Diagnosis

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    (b) Podophylline (c) Interferon (d)

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    (c) Cytarabine (d) Cycloserine 51.

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    Immunomodulators Explanations 1. An

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    Immunomodulators 14. Ans. (a) Syste

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    Immunomodulators 33. Ans. (a) Gluco

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    CHAPTER 17 Other Topics and Adverse

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    Other Topics and Adverse Effects Co

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    Other Topics and Adverse Effects Co

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    Other Topics and Adverse Effects Co

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    17. A 2 years old child without fev

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    54. Isotretinoin is: (PGI June, 200

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    Other Topics and Adverse Effects (c

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    Other Topics and Adverse Effects

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    Other Topics and Adverse Effects

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    Other Topics and Adverse Effects 39

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    Other Topics and Adverse Effects 55

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    Other Topics and Adverse Effects Dr

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    CHAPTER 18 Drugs of Choice Drug of

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    Drugs of Choice Contd... Hypertensi

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    Contd... VRSA LINEZOLID/STREPTOGRAM

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    CHAPTER 19 New Drugs 1. Abatacept:

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    New Drugs 52. Canakinumab: A human

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    New Drugs 100. Ecallantide: A plasm

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    New Drugs 153. Laronidase: Recombin

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    New Drugs 204. Peginesatide: A pept

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    New Drugs been approved for the tre

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    New Drugs and B lymphocytes after e

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    New Drugs prevents nausea and vomit

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    CHAPTER 20 Recent Topics TRICYCLIC

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    Recent Topics 2. Drugs 5-HT 2 recep

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    Recent Topics Arginine NOS NO + Cit

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    Recent Topics Contd... Drug Tetracy

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    Recent Topics -- If the patient has

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    CHAPTER 21 Latest Papers AIIMS Nove

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    Latest Papers explanations 1. Ans.

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    • Clindamycin and erythromycin ar

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    Latest Papers AIIMS May 2014 1. Whi

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    Latest Papers explanations 1. Ans.

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    13. Ans. a. Hypokalemia (Ref: Harri

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    NOTES _____________________________

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    Image Based Questions https://kat.c

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    Image Based Questions 1. The result

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    5. A new antiarrhythmic drug is fou

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    10. Amarnath, a 58 year old busines

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    14. A 72-year-old male, Hemraj was

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    (rapid vs slow induction of anesthe

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