Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Chemotherapy C: Antineoplastic Drugs<br />

652<br />

<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

18. Bleomycin toxicity affects which type <strong>of</strong> cells:<br />

(a) Type-I pneumocytes (AI 2009)<br />

(b) Type-II pneumocytes<br />

(c) Endothelial cells<br />

(d) Pulmonary alveolar macrophages<br />

19. SIADH is caused by all except: (AIIMS May 2008)<br />

(a) Vincristine<br />

(b) Vinblastine<br />

(c) Actinomycin D<br />

(d) Cyclophosphamide<br />

20. Sustained neutropenia is seen with? (AIIMS May 2008)<br />

(a) Vinblastine<br />

(b) Cisplatin<br />

(c) Carmustine<br />

(d) Cyclophosphamide<br />

21. Ifosfamide belongs to which group <strong>of</strong> anticancer<br />

drugs? (AIIMS Nov 2008)<br />

(a) Alkylating agents (AI 2009)<br />

(b) Antimetabolites (DNB 2008)<br />

(c) Mitotic inhibitors<br />

(d) Topoisomerase inhibitors<br />

22. Which <strong>of</strong> the following anticancer drug is excreted by<br />

lungs? (AIIMS Nov 2008)<br />

(a) 5-Fluorouracil<br />

(b) Cyclophosphamide<br />

(c) Doxorubicin<br />

(d) Cisplatin<br />

23. Mechanism <strong>of</strong> action <strong>of</strong> paclitaxel is: (AI 2008)<br />

(a) Topoisomerase inhibition (Kolkata 2009)<br />

(b) Increases the polymerization <strong>of</strong> tubulin (UP 2005)<br />

(c) Inhibits protein synthesis<br />

(d) Alkylation <strong>of</strong> DNA<br />

24. Which antineoplastic drug is a peptide? (AI 2008)<br />

(a) Bleomycin<br />

(b) Asparteme<br />

(c) Valinomycin<br />

(d) Dactinomycin<br />

25. Leucovorin is used to decrease the toxicity <strong>of</strong>:<br />

(a) Methotrexate (AI 2008, DNB 2001, TN 2002)<br />

(b) 6-Mercaptopurine<br />

(c) Thio-TEPA<br />

(d) Cytosine arabinoside<br />

26. All-trans-retinoic acid is used in treatment <strong>of</strong>: (AI 2008)<br />

(a) Acute promyelocytic leukemia<br />

(b) A.L.L.<br />

(c) CML<br />

(d) Transient myeloproliferative disorder<br />

27. Which <strong>of</strong> the following anticancer drugs can cause<br />

hypercoagulable state? (AI 2007)<br />

(a) 5-FU<br />

(b) L-asparaginase<br />

(c) Melphalan<br />

(d) Carmustine<br />

28. Anticancer drug causing SIADH as an adverse effect is:<br />

(a) Vincristine (AI 2007)<br />

(b) Paclitaxel<br />

(c) Dacarbazine<br />

(d) Cyclophosphamide<br />

29. High dose methotrexate is used for the treatment <strong>of</strong>:<br />

(a) Osteosarcoma (AI 2007<br />

(b) Rhabdomyosarcoma<br />

(c) Retinoblastoma<br />

(d) Ewing’s sarcoma<br />

30. Which <strong>of</strong> the following drugs is topoisomerase 1<br />

inhibitor?<br />

(AI-2005)<br />

(a) Doxorubicin<br />

(b) Irinotecan<br />

(c) Etoposide<br />

(d) Vincristine<br />

31. All <strong>of</strong> the following anticancer agents cause bone<br />

marrow suppression EXCEPT: (AI 2004)<br />

(a) Chlorambucil<br />

(b) Daunorubicin<br />

(c) Doxorubicin<br />

(d) Flutamide<br />

32. All <strong>of</strong> the following statements about methotrexate are<br />

correct EXCEPT: (AI 2001)<br />

(a) Folinic acid enhances the action <strong>of</strong> methotrexate<br />

(b) Methotrexate inhibits dihydr<strong>of</strong>olate reductase<br />

(c) Non-proliferative cells are resistant to methotrexate<br />

(d) Methotrexate is used in the treatment <strong>of</strong> psoriasis<br />

33. Mesna is given with cyclophosphamide to: (AI 2000)<br />

(a) Increase absorption<br />

(b) Decreased excretion<br />

(c) Ameliorate hemorrhagic cystitis<br />

(d) Decrease metabolism<br />

34. Which <strong>of</strong> the following is an anti-metabolite?<br />

(a) Methotrexate (AIIMS May, 2007)<br />

(b) Cyclosporine<br />

(c) Etoposide<br />

(d) Vinblastine<br />

35. Which <strong>of</strong> the following drugs is associated with untoward<br />

side effect <strong>of</strong> renal tubular damage?<br />

(a) Cisplatin (AIIMS May, 2006)<br />

(b) Streptozocin<br />

(c) Methysergide<br />

(d) Cyclophosphamide<br />

36. Which <strong>of</strong> the following chemotherapeutic agents is<br />

associated with secondary leukemia? (AIIMS May, 2006)<br />

(a) Vinblastine<br />

(b) Paclitaxel<br />

(c) Cisplatin<br />

(d) Bleomycin<br />

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