Review of Pharmacology - 9E (2015)

Endocrinology
113. Which of the following steroids is preferred for high
dose intravenous corticosteroid pulse therapy?
(a) Cortisone
(b) Hydrocortisone
(c) Triamcinolone
(d) Methyl-prednisolone
114. Select the regime of corticosteroids which has the
maximum adverse effect potential?
(a) Prednisolone 20 mg/day oral for one year
(b) Prednisolone 60 mg/day oral for 7 days
(c) Dexamethasone 4 mg intravenous daily for 3 days
(d) Methyl-prednisolone 1000 mg intravenous twice
single dose
115. Which of the following disorders is NOT aggravated by
corticosteroid therapy?
(a) Congenital adrenal hyperplasia
(b) Diabetes mellitus
(c) Hypertension
(d) Peptic ulcer
116. In the treatment of congenital adrenal hyperplasia due to
lack of 21 β-hydroxylase, the purpose of administration
of a synthetic glucocortocoid is:
(a) Inhibition of aldosterone synthesis
(b) Prevention of hypoglycemia
(c) Recovery of normal immune function
(d) Suppression of ACTH secretion
117. Toxic effects of long term administration of a glucocortocoid
include:
(a) Hepatotoxicity
(b) Osteoporosis
(c) Precocious puberty
(d) Lupus like syndrome
118. A patient Dharampal has been diagnosed to have bronchial
asthma and is maintained on oral prednisolone 20
mg daily and inhaled salbutamol as required. The patient
develops chest infection. Which of the following
measures would you like to take?
(a) Stop prednisolone
(b) Reduce prednisolone dose to 5 mg/day
(c) No change/increase in prednisolone dose
(d) Substitute prednisolone with inhaled budesonide
119. Shanti has been diagnosed to have brain tumor. You
would prefer to give her betamethasone/dexamethasone
over hydrocortisone as steroids to decrease her cerebral
edema because:
(a) They do not cause Na + and water retention
(b) They are more potent
(c) They can be administered intravenously
(d) They inhibit brain tumours
120. A 50 year old man with advanced tuberculosis has
developed signs of severe acute adrenal insufficiency.
The patient should be treated immediately with a
combination of:
(a) Aldosterone and fludrocortisone
(b) Triamcinolone and dexamethasone
(c) Cortisol and fludrocortisone
(d) Dexamethasone and metyrapone
121. Long term steroid therapy can lead to suppression of
hypothalamic-pituitary-adrenal axis. It can be overcome
by using alternate day therapy with corticosteroids.
Which of the following steroids are unsuitable for
alternate day therapy for such purpose?
(a) Cortisol
(b) Prednisolone
(c) Betamethasone
(d) Hydrocortisone
122. Which is not true about beclomethasone? (DPG 2010)
(a) Indicated for chronic use
(b) Inhalational steroid
(c) Effective in acute asthma
(d) Predispose to fungal infections
123. Most potent mineralocorticoid is:
(a) Aldosterone (TN 2000, DPG 2008)
(b) DOCA
(c) Fludrocortisone
(d) Triamcinolone
124. All are side effects of steroids EXCEPT: (DG 2008)
(a) Skin atrophy
(b) Telengectasia
(c) Folliculitis
(d) Photosensitivity
125. Systemic steroids can cause all of the following
EXCEPT: (DPG 2004)
(a) Hypertension
(b) Glaucoma
(c) Cataract
(d) Osteoporosis
126. Compared to hydrocortisone maximum glucocorticoid
action is found in: (DPG 2004)
(a) Dexamethasone
(b) Prednisolone
(c) Methyl prednisolone
(d) Cortisone
127. Steroids are contraindicated in all, EXCEPT: (DPG 2003)
(a) Diabetes mellitus
(b) Hypertension
(c) Eczematous skin disease
(d) Peptic ulcer disease
128. Oral contraceptive failure can occur with:
(a) Insulin (UP 2007, MH 2000, DPG 2003)
(b) Rifampicin
General Endocrinology Pharmacology
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