Review of Pharmacology - 9E (2015)

Central Nervous System
346
Review of Pharmacology
(b) Carbamazepine can be used in trigeminal neuralgias
(c) Diazepam is an anticonvulsant drug
(d) Lamotrigine mainly acts by causing GABA mediated
CI – channel opening
63. A 65 years old male presented to a hospital with focal
seizures. His renal function was normal. Which of the
following is the drug of choice for this patient?
(a) Valporate
(AIIMS Nov-2011)
(b) Pregbalin
(c) Levetiracetam
(d) Oxcarbazepine
64. Which among the following is an early sign of magnesium
toxicity? (AI 2011)
(a) Depression of deep tendon reflexes
(b) Respiratory depression
(c) Cardiac arrest
(d) Decreased urine output
65. A pregnant woman with primary generalized tonicclonic
seizures, well controlled on Phenobarbital, stops
taking her antiepileptic medication 4 months into her
pregnancy. Which of the following best describes her
decision? (DPG 2011)
(a) Her decision is wrong, as the risk of teratogenicity
was the highest in the first trimester
(b) Her decision is wrong because antiepileptic drugs do
not increase the risk of fetal malformations
(c) Her decision is correct as the risk of seizures is reduced
in pregnancy
(d) Her decision is wrong but her medication needs to
be changed and a newer antiepileptic drug added
66. All of the following are used for myoclonic seizures
except: (AI 2010)
(a) Sodium valproate
(b) Zonisamide
(c) Carbamazepine
(d) Topiramate
67. Fetal hydantoin syndrome is seen if following drug is
used in pregnancy? (AI 2010)
(a) Phenytoin
(b) Alcohol
(c) Ethosuximide
(d) Phenobarbitone
68. All of the following statements about phenytoin are
true except: (AI 2010)
(a) It follows saturation kinetics
(b) Anti-seizure activity closely resembles plasma concentration
(c) Does not depress CNS
(d) Cerebellar degeneration occurs on long-term administration
69. Ethosuximide can be used for the treatment of:
(a) Generalized tonic clonic seizures
(b) Absence seizures (AI 2010)
(c) Complex seizures
(d) Myoclonic seizures
70. Which of the following statement about phenytoin is
true? (AIIMS Nov 2009)
(a) It follows zero order kinetics
(b) It is not teratogenic
(c) It is excreted unchanged in urine
(d) It does not induce microsomal enzymes
71. The drug of choice for prevention of seizures in a
patient with severe preeclampsia is: (DPG 2009)
(a) Phenytoin
(b) Magnesium sulphate
(c) Diazepam
(d) Nifedipine
72. All of the following are adverse effects of sodium
valproate except: (AI 2009)
(a) Weight gain
(b) Alopecia
(c) Liver damage
(d) Osteomalacia
73. Which statement is true about carbamazepine?
(a) Used in trigeminal neuralgia (AIIMS May 2008)
(b) Carbamazepine is an enzyme inhibitor
(c) Can cause megaloblastic anemia
(d) It is the drug of choice for status epilepticus
74. First drug to be used in absence seizures is:
(a) Phenytoin (AIIMS May 2008)
(b) Benzodiazepines
(c) Valproate
(d) Carbamazepine
75. Which of the following drugs is not an anticonvulsant?
(a) Phenytoin (AI 2007)
(b) Flunarizine
(c) Topiramate
(d) Phenobarbitone
76. Which antiepileptic drug does not act via inhibition of
sodium channels? (AI 2007)
(a) Vigabatrin
(b) Carbamazepine
(c) Lamotrigine
(d) Phenytoin
77. Granulocytopenia, gingival hyperplasia and facial hirsutism
are all possible side effects of one of the following
anticonvulsant drugs? (AI 2003)
(a) Phenytoin
(b) Valproate
(c) Carbamazepine
(d) Phenobarbitone
78. A patient on phenytoin therapy develops depression,
for which he was prescribed tricyclic anti-depressants.
He now complains of lassitude and his Hb reading is 8
gm/dl, the next step in the management of this patient
is: (AI 2001)
(a) Chest X ray
(b) MCV should be estimated
(c) GGT should be estimated
(d) None of the above
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