Review of Pharmacology - 9E (2015)

Autonomic Nervous System
78
Review of Pharmacology
15. Which of the following antiglaucoma medication is
UNSAFE in infants? (DPG 2009)
(a) Timolol
(b) Brimonidine
(c) Latanoprost
(d) Dorzolamide
16. Mechanism of action of pralidoxime is: (AI-2008)
(a) Stimulation of ACh receptors
(b) Inhibition of breakdown of ACh
(c) Blockade of ACh receptors
(d) Reactivation of AChE enzyme
17. Diagnosis of myasthenia gravis is done by using:
(a) Edrophonium (AI 2000)
(b) Neostigmine
(c) Succinylcholine
(d) Atropine
18. Which of the following statements is FALSE?
(a) Hemicholinium prevents the release of ACh from
storage vesicles (PGI Dec. 2005)
(b) Botulinum toxin increase the ACh release
(c) Pralidoxime reactivates acetylcholine esterase
(d) Vesamicol inhibit the uptake of choline
(e) Organophosphates inhibit acetyl-cholinesterase
19. True statements about neostigmine are: (PGI Dec. 2004)
(a) It is a quartarnary ammounium compound
(b) It is metabolised by liver
(c) It can cross the blood brain barrier
(d) Prominent effect on cardiac muscle
(e) It possess agonistic action on N M
receptors
20. All of the following effects are seen with cholinergic
muscarinic receptor stimulation except:
(a) Sweating
(b) Rise in blood pressure
(c) Bradycardia
(d) Urination
21. A patient Raj Kishore was given pilocarpine. All of the
following can be the features seen in him except:
(a) Sweating
(b) Salivation
(c) Miosis
(d) Cycloplegia
22. Which of the following provides the best explanation
for neostigmine being preferred over physostigmine
for treating myasthenia gravis?
(a) It is better absorbed orally
(b) It has longer duration of action
(c) It has additional direct agonistic action on nicotinic
receptors at the muscle end plate
(d) It penetrates blood brain barrier
23. Which of the following properties make pyridostigmine
different from neostigmine?
(a) It is more potent
(b) It is longer acting
(c) It produces less muscarinic side effects
(d) It does not have any direct action on N M
receptors
24. Dr Sunil used edrophonium for differentiating myasthenic
crisis from cholinergic crisis. He preferred it over
other anticholinesterase agents because of its:
(a) Shorter duration of action
(b) Longer duration of action
(c) Direct action on muscle end plate
(d) Selective inhibition of true cholinesterase
25. Agonistic action at which of the following adrenergic
receptors results in the reduction of aqueous secretion?
(a) β 1
receptor
(b) β 2
receptor
(c) M 2
receptor
(d) α 2
receptor
26. You are in the eye OPD and wish to use a topical beta
blocker in a patient. The chosen drug by you should
have all the following properties except:
(a) Strong local anaesthetic activity
(b) High lipophilicity
(c) High ocular capture
(d) Low systemic activity
27. Which of the following is the longest acting ocular beta
blocker?
(a) Timolol
(b) Betaxolol
(c) Cartiolol
(d) Metoprolol
28. Several children at a summer camp were hospitalized
with symptoms thought to be due to ingestion of food
containing botulinum toxin. The effects of botulinum
toxin are likely to include:
(a) Bronchospasm
(b) Cycloplegia
(c) Diarrhea
(d) Skeletal muscle spasms
29. A direct acting cholinomimetic that is lipid soluble and
has been used in the treatment of glaucoma is:
(a) Acetylcholine
(b) Physostigmine
(c) Pilocarpine
(d) Neostigmine
30. Drug of choice for treatment of acute organophosphate
poisoning is:
(a) Atropine
(b) Pralidoxime
(c) Neostigmine
(d) d- Tubocurarine
31. Sunder Lal, 28 year old farmer is found convulsing
in the farm. Heart rate is 100/min and blood pressure
is 180/110 mm Hg. Diarrhea, sweating and urination
are apparent. Pupils are pin point. Drug poisoning is
suspected. Most probable cause is:
(a) Acetaminophen overdose
(b) Amphetamine toxicity
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