Review of Pharmacology - 9E (2015)

Anaesthesia
416
Review of Pharmacology
(b) By surface application, it can anaesthetize unbroken
skin
(c) It is not absorbed after surface application
(d) It has strong vasoconstrictor action
15. The segmental level of spinal anaesthesia depends on:
(a) Volume of the local anaesthetic injected
(b) Specific gravity of the local anaesthetic solution
(c) Posture of the patient
(d) All of the above
16. In spinal anaesthesia the segmental level of:
(a) Sympathetic block is lower than the sensory block
(b) Sympathetic block is higher than the sensory block
(c) Motor block is higher than the sensory block
(d) Sympathetic, motor and sensory block has the same
level
17. The duration of spinal anaesthesia depends on all of
the following EXCEPT:
(a) Local anaesthetic that is used
(b) Concentration of the local anesthetic used
(c) Posture of the patient
(d) Whether adrenaline has been added to the local
anaesthetic
18. Intravenous regional anaesthesia is suitable for:
(a) Orthopedic manipulation on the upper limb
(b) Vascular surgery on the lower limb
(c) Head and neck surgery
(d) Caesarian section
19. Most cardiotoxic local anaesthetic is:
(a) Procaine
(b) Bupivacaine
(c) Prilocaine
(d) Tetracaine
20. A patient receives a toxic dose of lignocaine i.v., the
patient is likely to exhibit:
(a) Excessive salivation
(b) Mydriasis and diarrhea
(c) Respiratory paralysis
(d) Seizures and coma
21. An agent added to local anesthetics to speed the onset
of action is:
(a) Methylparapben
(b) Bicarbonate
(c) Fentanyl
(d) Adrenaline
22. Epinephrine added to a solution of lignocaine for a
peripheral nerve block will:
(a) Increase risk of convulsions
(b) Increase the duration of action of the local anesthetic
(c) Both (a) and (b)
(d) None of these
23. All of the following are properties of local anesthetics
EXCEPT:
(a) Blockade of voltage dependent Na + channels
(b) Preferential binding to resting channels
(c) Slowing of axonal impulse conduction
(d) Increase in the membrane refractory period
24. The most important adverse effect of i.v. administration
of large dose of an amide anesthetic is:
(a) Bronchoconstriction
(b) Hepatic damage
(c) Renal failure
(d) Seizures
25. Ram has a 4 ml lignocaine vial of 2% solution. How
much lignocaine is present in 1 ml?
(a) 2 mg
(b) 8 mg
(c) 20 mg
(d) 200 mg
26. Which of the following drugs has a high surface activity
and vasoconstrictor actions that reduce bleeding in
mucus membranes?
(a) Bupivacaine
(b) Cocaine
(c) Lidocaine
(d) Procaine
27. All are vasodilators except: (DPG 2010)
(a) Procaine
(b) Lidocaine
(c) Cocaine
(d) Chlorprocaine
28. Which of the following local anaesthetics belongs to the
ester group? (DPG 2010)
(a) Procaine
(b) Bupivacaine
(c) Lignocaine
(d) Mepivacaine
29. The following statements about Bupivacaine are true
except: (DPG 2010)
(a) Must never be injected into a vein
(b) More cardiotoxic than lignocaine
(c) 0.5 percent is effective for sensory block
(d) It produces methaemoglobinemia
30. Local anesthetics act by: (DPG 2006)
(a) Affecting at the spinal level
(b) Affecting the Na + channels
(c) Affecting the K + channels
(d) Blocking axonal transport
31. Local anesthetics: (MPPG 2002)
(a) Block the release of neurotransmitters
(b) Block the influx of sodium into the cell
(c) Increase the release of inhibitory neurotrans-mitters
(d) Inhibit the efflux of sodium from neurons
32. All are true about bupivacaine Except:
(a) Less cardiotoxic than lignocaine (UP 2007)
(b) Dose increases with adrenaline
(c) Long acting
(d) Cannot given in vein
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