Review of Pharmacology - 9E (2015)

Central Nervous System
366. Ans. (b) Cocaine (Ref: CMDT 2010, 983)
Cocaine is a product of coca plant and it is also a stimulant like amphetamine. Both of these are addictive and sympathomimetic
substances.
367. Ans. (d) Sublingual (Ref: KDT 6/e p458, KK Sharma 2nd/500)
368. Ans. (c) Synthetic derivatives (Ref: Principles of Pharmacology by HL Sharma and KK Sharma, 1st/509)
Term Opiate means from ‘opium’ whereas opioid means opium like analgesics.
369. Ans. (d) Morphine (Ref: Principles of Pharmacology by HL Sharma and KK Sharma 1st/509; KDT 6/e p458)
Answers of recent Questions asked by National Board
1. Ans (b) Tardive dyskinesia (Ref. KDT 7/e p444)
2. Ans (b) GABA – agonism (Ref. KDT 7/e p421)
3. Ans (a) Anxiolytic (Ref. KDT 7/e p466)
4. Ans (c) Triazolam (Ref. KDT 7/e p405)
5. Ans (a) Alcohol de-addiction (Ref. KDT 7/e p394)
6. Ans (b) Can be mixed with dextrose (Ref. KDT 7/e p415)
7. Ans (b) Venlafaxine (Ref. KDT 7/e p462)
8. Ans (a) Clozapine (Ref. KDT 7/e p444)
9. Ans (b) Anti-psychotics (Ref. KDT 7/e p444)
10. Ans (c) 2.0 mEq/L (Ref. KDT 7/e p449)
11. Ans. (b) Zolpidem (Ref: KDT 7/e p406)
12. Ans. (b) Fentanyl (Ref: KDT 7/e p478)
13. Ans. (a) Vigabatrin (Ref: KDT 7/e p421)
14. Ans. (d) 5 HT 2C
(Ref: Goodman Gilman 12/e p435)
• Antipsychotics cause weight gain due to their antagonistic action on H 1
and 5HT 2C
receptors.
15. Ans. (d) Valproate (Ref: KDT 7/e p 421)
16. Ans. (c) Retroperitoneal Fibrosis (Ref: KDT 7/e p 431)
• Adverse effects of ropinirole and pramipexole include nausea, dizzinesss, hallucinations, postural hypotension and
excessive day time sleepiness
• Their advantage over ergot derivatives like bromocriptine is lack of retroperitoneal fibrosis and gangrene and long
duration of action.
• Ropinirole has been approved by FDA for restless leg syndrome
17. Ans. (d) Pergolide (Ref: KDT 7/e p 430)
18. Ans. (c) Constipation (Ref: KDT 7/e p473)
19. Ans. (a) It is an enzyme inducer (Ref: KDT 7/e p417)
20. Ans. (d) It inhibits microsomal enzymes (Ref: KDT 7/e p413-415)
21. Ans. (a) Amiloride (Ref: KDT 7/e p598)
22. Ans. (c) Lipid soluble (Ref: KDT 7/e p415)
• Fosphenytoin is water soluble prodrug of phenytoin developed to overcome the difficulties in i.v. administration of
phenytoin.
23. Ans. (d) Amitriptyline (Ref: KDT 7/e p454)
24. Ans. (a) Tramadol (Ref: KDT 7/e p477)
• Tramadol inhibits re-uptake of NA and 5-HT and thus activates monoaminergic spinal inhibition of pain.
General Central Nervous Pharmacology System
25. Ans. (b) Flumazenil (Ref: KDT 7/e p408)
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