Review of Pharmacology - 9E (2015)

(b) Podophylline
(c) Interferon
(d) Acyclovir
16. All of the following are the adverse effects of Tacrolimus
EXCEPT:
(AI-2008)
(a) Nephrotoxicity
(b) Neurotoxicity
(c) Hirsutism
(d) Hyperglycemia
17. All of the following statements about immunosuppressants
are true EXCEPT: (AI 2007)
(a) Sirolimus acts by inhibiting the action of 1L-2.
(b) Tacrolimus inhibits calcineurin pathway
(c) Mycophenolate acts by inhibiting GMP dehydrogenase
(d) Cyclosporine is an integeral component of transplant
rejection regimen
18. One of the following statements regarding mycophenolate
mofetil is INCORRECT: (AI 2006)
(a) It is a prodrug
(b) It is a selective, uncompetitive and reversible
inhibitor of IMP dehydrogenase
(c) It inhibits calcineurin
(d) Selectively inhibits lymphocytic proliferation
19. Which of the following statements is not true about
Tacrolimus? (AI 2004)
(a) It is a macrolide antibiotic
(b) It is indicated for the prophylaxis of organ transplant
rejection
(c) Glucose intolerance is a well recognized side effect
(d) It can be safely administered with any nephrotoxic
drug
20. Donesumab, a monoclonal antibody against RANK ligand
is used for the treatment of: (AIIMS Nov 2006)
(a) Rheumatoid arthritis
(b) Osteoporosis
(c) Osteoarthritis
(d) Systemic lupus erythematosis
21. All of the following are immunosuppressive drugs EX-
CEPT: (AIIMS May, 2004)
(a) Cyclosporine
(b) Cefaclor
(c) Azathioprine
(d) Steroids
22. Which of the following pairs are incorrectly matched:
(a) Abciximab – Antiplatelet (PGI Dec. 2007)
(b) Omalizumab – Colon carcinoma
(c) Rituximab – Rheumatoid arthritis
(d) Trastuzumab – her/2/neu +ve breast carcinoma
(e) Palivizumab – Psoriasis
23. Thalidomide can be used in: (AIIMS May, 2004)
(a) Myocardial infarction
(b) Erythema nodosum leprosum
(c) Wernicke’s encephalopathy
(d) Epilepsy
Immunomodulators
24. FK 506 is a type of: (AIIMS May, 2007)
(a) Immunoglobulin antibody
(b) Non-depolarizing muscle relaxant
(c) Macrolide antibiotic
(d) Opioid anaesthetic
25. Complications of cyclosporine therapy are:
(a) Hypertension (PGI June, 2006)
(b) Pulmonary fibrosis
(c) Hirsutism
(d) Nephrotoxicity
(e) Hyperkalemia
26. Drugs inhibiting the formation of IL-2 are:
(a) Cycloserine (PGI June, 2004)
(b) Cyclosporine
(c) OKT-3
(d) Tacrolimus
27. A 50 year old male, Ram Lal suffering from renal failure,
underwent kidney transplant. He was prescribed a
nucleotide derivative following the organ transplant.
The nucleotide derivative of therapeutic importance in
this organ transplant is: (AIIMS Nov, 2003) (DPG 2008)
(a) Azathioprine
(b) 5-Fluorouracil
(c) Cytarabine
(d) Allopurinol
28. The immunosuppressant action of cyclosporine appears
to be due to:
(a) Activation of NK cells
(b) Blockade of tissue responses to inflammatory
mediators
(c) Inhibition of gene transcription of interleukins
(d) Interference with antigen recognition
29. Sirolimus is more likely than cyclosporine to cause:
(a) Hypertension
(b) Osteoporosis
(c) Renal insufficiency
(d) Thrombocytopenia
30. An agent that activates natural killer cells and is useful
in renal cell carcinoma is:
(a) Aldesleukin
(b) Etanercept
(c) Leflunomide
(d) Thalidomide
31. Which of the following monoclonal antibodies is a
humanized antibody?
(a) Rituximab
(b) Palivizumab
(c) Infliximab
(d) Basiliximab
681
General Immunomodulators
Pharmacology
https://kat.cr/user/Blink99/